DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10147 and ZNF671

DIOPT Version :9

Sequence 1:	NP_001261477.1	Gene:	CG10147 / 38733	FlyBaseID:	FBgn0035702	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_079109.2	Gene:	ZNF671 / 79891	HGNCID:	26279	Length:	534	Species:	Homo sapiens

Alignment Length:	490	Identity:	136/490 - (27%)
Similarity:	194/490 - (39%)	Gaps:	133/490 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DEAYNLLHHPYLAVKFSECTNLVVDPDDQDILPSEICSECYELLEKFHSFRALCIIADNKWRSKS 82
            |:|..||:|                    |:           :||.|....:|.|...   ||::
Human    67 DDAQRLLYH--------------------DV-----------MLENFALLASLGIAFS---RSRA 97

  Fly    83 LVTWKKIDR-RKP-VY-EVD---------------------EDEEEELE--------------LE 109
            ::   |::| .:| || :||                     ||||...|              :.
Human    98 VM---KLERGEEPWVYDQVDMTSATEREAQRGLRPGCWHGVEDEEVSSEQSIFVAGVSEVRTLMA 159

  Fly   110 ELLLEPPEM---IICDT-NLS------AQNTPIVAEQAPPTLVFHT-FTENVQQP------PETE 157
            ||...|.::   |:.|| :|:      |:..|.:.........|.| |.::..||      |..|
Human   160 ELESHPCDICGPILKDTLHLAKYHGGKARQKPYLCGACGKQFWFSTDFDQHQNQPNGGKLFPRKE 224

  Fly   158 -----KKALEEPPLTTYKCDLCADEFREEKRLILHK------KEHQGHML---------YH-CTE 201
                 |......|..|..|.....:|.....|:.|:      |.|:...|         || |.|
Human   225 GRDSVKSCRVHVPEKTLTCGKGRRDFSATSGLLQHQASLSSMKPHKSTKLVSGFLMGQRYHRCGE 289

  Fly   202 PGCEEAFNRFENLRQHELEHSEVGMR-FVCEEEGCNRMYRHKASLKYHQSKAHDIGKPLKTHMCE 265
              |.:||.|.:.|.:|:..|:  |.| :.|.|  |.:.:.....|..||: .|...:|   :.|.
Human   290 --CGKAFTRKDTLARHQRIHT--GERPYECNE--CGKFFSQSYDLFKHQT-VHTGERP---YECS 344

  Fly   266 FCGRVFKTGSALSQHRFTH-GDQLVLPYACELPECSMRFYSTEKLKIHMMRHQGIKNFSCPYCGL 329
            .||:.|:..|.|.:||..| |::|   |.|  .:|...|.|...|..|...|.|.:.:.|..||.
Human   345 ECGKFFRQISGLIEHRRVHTGERL---YQC--GKCGKFFSSKSNLIRHQEVHTGARPYVCSECGK 404

  Fly   330 KKTTKNELRLHINYHTLERTWSCKDCPKVCNSSTSLKKHIRAIHEKARDYACSYCEKKFATTDTR 394
            :.:.|:.|.||...||.||.:.|.:|.|..:.|:.|..|.| ||  :.||.||.|.|.|:.....
Human   405 EFSRKHTLVLHQRTHTGERPYECSECGKAFSQSSHLNVHWR-IH--SSDYECSRCGKAFSCISKL 466

  Fly   395 KYHEMTHTGEKNFECHVCGKKFIQPSALRTHRKVH 429
            ..|:..|:|||.:||..|||.|.|...|..|.|||
Human   467 IQHQKVHSGEKPYECSKCGKAFTQRPNLIRHWKVH 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_001261477.1	zf-AD	7..80	CDD:214871	11/61 (18%)
		C2H2 Zn finger	171..191	CDD:275368	5/25 (20%)
		zf-C2H2_8	199..287	CDD:292531	29/89 (33%)
		C2H2 Zn finger	199..221	CDD:275368	8/21 (38%)
		C2H2 Zn finger	230..253	CDD:275368	6/22 (27%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		C2H2 Zn finger	294..316	CDD:275368	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	9/19 (47%)
ZNF671	NP_079109.2	KRAB	49..109	CDD:214630	16/78 (21%)
		KRAB	49..88	CDD:279668	9/51 (18%)
		C2H2 Zn finger	243..269	CDD:275368	5/25 (20%)
		COG5048	<285..443	CDD:227381	56/172 (33%)
		zf-C2H2	285..307	CDD:278523	9/23 (39%)
		C2H2 Zn finger	287..307	CDD:275368	8/21 (38%)
		zf-H2C2_2	300..324	CDD:290200	8/27 (30%)
		C2H2 Zn finger	315..335	CDD:275368	6/22 (27%)
		zf-H2C2_2	327..352	CDD:290200	9/28 (32%)
		C2H2 Zn finger	343..363	CDD:275368	8/19 (42%)
		zf-C2H2	369..391	CDD:278523	7/23 (30%)
		C2H2 Zn finger	371..391	CDD:275368	6/21 (29%)
		zf-C2H2	397..419	CDD:278523	7/21 (33%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		zf-H2C2_2	412..436	CDD:290200	10/23 (43%)
		C2H2 Zn finger	427..447	CDD:275368	7/20 (35%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		zf-H2C2_2	466..490	CDD:290200	11/23 (48%)
		C2H2 Zn finger	481..501	CDD:275368	9/19 (47%)
		C2H2 Zn finger	509..529	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100