DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10147 and ZNF408

DIOPT Version :9

Sequence 1:	NP_001261477.1	Gene:	CG10147 / 38733	FlyBaseID:	FBgn0035702	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_079017.1	Gene:	ZNF408 / 79797	HGNCID:	20041	Length:	720	Species:	Homo sapiens

Alignment Length:	368	Identity:	101/368 - (27%)
Similarity:	147/368 - (39%)	Gaps:	61/368 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 DEDEEEELELEELLLEPPEMIICDTNLSAQNTP-------------------------IVAEQAP 138
            |.|.:||...:..:  |||:   .:|.:.|..|                         ..::|.|
Human   258 DGDVDEECPAQAQM--PPEL---QSNSATQQDPDGSGASFSSSARGTQPHGYLAKKLHSPSDQCP 317

  Fly   139 PTLV----------FHTFTENVQQPPETEKKALEEPPLTTYKCDLCADEFREEKRLILHKKEHQG 193
            |...          |.|.:.:...|..:..|....     |:|..|...|.:...|..|...|.|
Human   318 PRAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGRR-----YRCGECGKAFLQLCHLKKHAFVHTG 377

  Fly   194 HMLYHCTEPGCEEAFNRFENLRQHELEHSEVGMR-FVCEEEGCNRMYRHKASLKYHQSKAHDIGK 257
            |..:.|||  |.::::..|:.:.|.|.|.  |:| |.|.:  |::.|..:..||.|| ..|...:
Human   378 HKPFLCTE--CGKSYSSEESFKAHMLGHR--GVRPFPCPQ--CDKAYGTQRDLKEHQ-VVHSGAR 435

  Fly   258 PLKTHMCEFCGRVFKTGSALSQHRFTHGDQL-VLPYACELPECSMRFYSTEKLKIHMMRHQGIKN 321
            |.   .|:.||:.|....:|..||.||  |: ..|..|..|.|.....:...|:.||..|.|.|.
Human   436 PF---ACDQCGKAFARRPSLRLHRKTH--QVPAAPAPCPCPVCGRPLANQGSLRNHMRLHTGEKP 495

  Fly   322 FSCPYCGLKKTTKNELRLHINYHTLERTWSCKDCPKVCNSSTSLKKHIRAIHEKARDYACSYCEK 386
            |.||:||.....:..||.|:..||.||.:.|..|.........|::|:  |......:.|..|.|
Human   496 FLCPHCGRAFRQRGNLRGHLRLHTGERPYRCPHCADAFPQLPELRRHL--ISHTGEAHLCPVCGK 558

  Fly   387 KFATTDTRKYHEMTHTGEKNFECHVCGKKFIQPSALRTHRKVH 429
            ......|.:.||..|:||:.|.|..||:.:...:.||.|.|.|
Human   559 ALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKSH 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_001261477.1	zf-AD	7..80	CDD:214871
		C2H2 Zn finger	171..191	CDD:275368	5/19 (26%)
		zf-C2H2_8	199..287	CDD:292531	29/88 (33%)
		C2H2 Zn finger	199..221	CDD:275368	7/21 (33%)
		C2H2 Zn finger	230..253	CDD:275368	7/22 (32%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		C2H2 Zn finger	294..316	CDD:275368	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..373	CDD:275368	4/20 (20%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
ZNF408	NP_079017.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..350		17/96 (18%)
		COG5048	<308..516	CDD:227381	64/224 (29%)
		C2H2 Zn finger	355..375	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..392	CDD:290200	9/26 (35%)
		C2H2 Zn finger	383..403	CDD:275368	7/21 (33%)
		C2H2 Zn finger	411..431	CDD:275368	7/22 (32%)
		zf-H2C2_2	423..448	CDD:290200	10/28 (36%)
		C2H2 Zn finger	439..490	CDD:275368	17/52 (33%)
		COG5048	<475..642	CDD:227381	41/129 (32%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..533	CDD:290200	9/22 (41%)
		C2H2 Zn finger	526..546	CDD:275368	5/21 (24%)
		C2H2 Zn finger	553..573	CDD:275368	6/19 (32%)
		zf-H2C2_2	566..589	CDD:290200	9/22 (41%)
		C2H2 Zn finger	581..601	CDD:275368	7/19 (37%)
		zf-H2C2_2	594..617	CDD:290200	5/8 (63%)
		C2H2 Zn finger	609..629	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000