DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10147 and Zfp935

DIOPT Version :9

Sequence 1:	NP_001261477.1	Gene:	CG10147 / 38733	FlyBaseID:	FBgn0035702	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_849206.2	Gene:	Zfp935 / 71508	MGIID:	1918758	Length:	353	Species:	Mus musculus

Alignment Length:	410	Identity:	105/410 - (25%)
Similarity:	167/410 - (40%)	Gaps:	62/410 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NLLHHPYLAVKFSECTNLVVDPDDQDILPSEICSECYELLEKFHSFRALCIIADNKWRSKSLVTW 86
            |.:.:..:.|.|::....::|| .|..|..::..|.|         |.|..|..| |.:.::..:
Mouse     2 NAVTYEDVHVNFTQEEWALLDP-SQKKLYKDVMVETY---------RNLNAIGFN-WEAHNIEEY 55

  Fly    87 KKIDRRKPVYEVDEDEEEELELEELLLEPPEMIICDTNLSAQNTPIVAEQAPPTLVFHTFTENVQ 151
            .:..||....|..:..|          :|.|...|....:              |..|:..:. .
Mouse    56 CQSSRRHRRCERSQSAE----------KPSEYTQCGKAFA--------------LHAHSHAQR-H 95

  Fly   152 QPPETEKKALEEPPLTTYKCDLCADEFREEKRLILHKKEHQGHMLYHCTEPGCEEAFNRFENLRQ 216
            :...|||        .|.:...|.::|.....|.:||:...|...|.|.:  |.:.|.....|::
Mouse    96 ERIHTEK--------ITSEVIHCVEDFLPYTSLQVHKRTQTGQKPYECNQ--CGKGFRMPSCLKR 150

  Fly   217 HELEHSEVGMR-FVCEEEGCNRMYRHKASLKYHQSKAHDIGKPLKTHMCEFCGRVFKTGSALSQH 280
            ||..|:  |.: :.|.:  |.:.:...:.||.|: :.|...||.|   |..|.:.|.....|..|
Mouse   151 HERIHT--GEKPYECNQ--CGKGFITPSHLKRHE-RIHTGEKPYK---CNQCDKAFSQYVHLQIH 207

  Fly   281 RFTH-GDQLVLPYACELPECSMRFYSTEKLKIHMMRHQGIKNFSCPYCGLKKTTKNELRLHINYH 344
            |.|| |::   |:.|:  ||...|.....|:.|...|.|.|.:.|..|....:....|.:|...|
Mouse   208 RSTHTGEK---PFKCD--ECDKAFSKHFHLQNHKRTHTGEKPYKCNQCNKAFSQHTNLHIHRRTH 267

  Fly   345 TLERTWSCKDCPKVCNSSTSLKKHIRAIHEKARDYACSYCEKKFATTDTRKYHEMTHTGEKNFEC 409
            |.|:.:.|.:|.||.:....|:.||:. |...:.|.|:.|.|.|....:.:.|...|||||.::|
Mouse   268 TGEKPFKCNECDKVFSQFGHLQIHIKT-HTGDKPYKCNQCNKAFYQKRSLQTHIRIHTGEKPYKC 331

  Fly   410 HVCGKKFIQPSALRTHRKVH 429
            :.|.|.|.|...|..||::|
Mouse   332 NQCDKAFSQYGHLYIHRRIH 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_001261477.1	zf-AD	7..80	CDD:214871	14/57 (25%)
		C2H2 Zn finger	171..191	CDD:275368	5/19 (26%)
		zf-C2H2_8	199..287	CDD:292531	26/89 (29%)
		C2H2 Zn finger	199..221	CDD:275368	6/21 (29%)
		C2H2 Zn finger	230..253	CDD:275368	5/22 (23%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..316	CDD:275368	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	4/19 (21%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
Zfp935	NP_849206.2	KRAB	4..>45	CDD:214630	11/50 (22%)
		KRAB	4..40	CDD:279668	9/45 (20%)
		C2H2 Zn finger	78..99	CDD:275368	3/35 (9%)
		COG5048	<130..293	CDD:227381	50/177 (28%)
		C2H2 Zn finger	135..155	CDD:275368	6/21 (29%)
		zf-H2C2_2	148..172	CDD:290200	7/27 (26%)
		C2H2 Zn finger	163..183	CDD:275368	5/22 (23%)
		zf-H2C2_2	175..200	CDD:290200	10/28 (36%)
		C2H2 Zn finger	191..211	CDD:275368	6/19 (32%)
		zf-H2C2_2	203..227	CDD:290200	10/28 (36%)
		C2H2 Zn finger	219..239	CDD:275368	6/21 (29%)
		zf-H2C2_2	231..256	CDD:290200	7/24 (29%)
		C2H2 Zn finger	247..267	CDD:275368	4/19 (21%)
		zf-H2C2_2	263..284	CDD:290200	8/20 (40%)
		C2H2 Zn finger	275..295	CDD:275368	7/20 (35%)
		zf-H2C2_2	287..310	CDD:290200	8/23 (35%)
		COG5048	298..>352	CDD:227381	20/54 (37%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		zf-H2C2_2	315..340	CDD:290200	10/24 (42%)
		C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000