DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10147 and Zfp966

DIOPT Version :9

Sequence 1:	NP_001261477.1	Gene:	CG10147 / 38733	FlyBaseID:	FBgn0035702	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001170878.1	Gene:	Zfp966 / 667962	MGIID:	3709288	Length:	485	Species:	Mus musculus

Alignment Length:	297	Identity:	91/297 - (30%)
Similarity:	140/297 - (47%)	Gaps:	48/297 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 EEPPLTTYKCDLCADEFREEKRLILHKKEHQGHMLYHCTEPGCEEAFNRFENLRQHELEHSEVGM 226
            |:|    |:|..|...|.:...|.:||:.|.|...|.|.:  |.:||.|...|:.|:..|:  |.
Mouse   203 EKP----YECKQCGKAFTQSSHLGIHKRTHTGEKPYECKQ--CGKAFTRSSTLQTHKQTHT--GE 259

  Fly   227 R-FVCEEEGCNRMYRHKASLKYHQSKAHDIGKPLKTHMCEFCGRVFKTGSALSQHRFTH-GDQLV 289
            : :.|::  |::.:..:..|:.|: :.|...||   :.|:.||:.|.....|..|:.|| |::
Mouse   260 KPYECKQ--CDKAFVRRGELQIHK-RTHTGEKP---YECKQCGKAFAQSGTLQIHKRTHTGEK-- 316

  Fly   290 LPYACELPECSMRFYSTEKLKIHMMRHQGIKNFSCPYCGLKKTTKNELRLHINYHTLERTWSCKD 354
             ||.|:  :|...|..:..|:||...|.|.|.:.|..|......:.||::|...||.|:.:.||.
Mouse   317 -PYECK--QCGKAFAHSSTLQIHKRTHTGEKPYECKQCDKAFVKRGELQIHKQTHTGEKPYECKQ 378

  Fly   355 CPKVCNSSTSLKKHIRA-----------------------IHEKA----RDYACSYCEKKFATTD 392
            |.|....|.:|:.|.|.                       |||:.    :.|.|..|.|.||.::
Mouse   379 CGKAFAQSGTLQVHERTHTGEKPFECNQCGKAFVQCIALRIHERTHTGEKPYECKQCGKAFAHSN 443

  Fly   393 TRKYHEMTHTGEKNFECHVCGKKFIQPSALRTHRKVH 429
            |.:.|:.||||||.:||..|||.|...|.|:.|::.|
Mouse   444 TLQIHKRTHTGEKPYECKQCGKAFAHSSTLQIHKQTH 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_001261477.1	zf-AD	7..80	CDD:214871
		C2H2 Zn finger	171..191	CDD:275368	6/19 (32%)
		zf-C2H2_8	199..287	CDD:292531	25/89 (28%)
		C2H2 Zn finger	199..221	CDD:275368	7/21 (33%)
		C2H2 Zn finger	230..253	CDD:275368	4/22 (18%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..316	CDD:275368	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..373	CDD:275368	8/43 (19%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
Zfp966	NP_001170878.1	KRAB	22..63	CDD:366587
		COG5048	94..478	CDD:227381	90/293 (31%)
		C2H2 Zn finger	99..116	CDD:275368
		C2H2 Zn finger	124..144	CDD:275368
		C2H2 Zn finger	152..172	CDD:275368
		C2H2 Zn finger	180..200	CDD:275368
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		C2H2 Zn finger	236..256	CDD:275368	7/21 (33%)
		C2H2 Zn finger	264..284	CDD:275368	4/22 (18%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	6/21 (29%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		C2H2 Zn finger	376..396	CDD:275368	8/19 (42%)
		C2H2 Zn finger	404..424	CDD:275368	3/19 (16%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		C2H2 Zn finger	460..480	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100