Protein Alignment CG10147 and SNAI1

DIOPT Version :10

• Sequence 1: NP_648046.1
• Gene: CG10147 / 38733
• FlyBaseID: FBgn0035702
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_005976.2
• Gene: SNAI1 / 6615
• HGNCID: 11128
• Length: 264
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 73/333 - (21%)
• Similarity: 119/333 - (35%)
• Gaps: 98/333 - (29%)

  Fly    81 KSLVTWKKID-RRKPVYEVDEDEEEELELEE------LL--LEPPE---------MIICDTNLSA 127
            :|.:..|..| .|||.|...:|...|...::      ||  :.|||         |:|.|:.|:.
Human     3 RSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAP 67

  Fly   128 QNTPIV-----AEQAPPTLVFHTFTE----NVQQPPETEKKALEEPPLTTYKCDLCADEFREEKR 183
            |..||.     .:::|......:.::    ...|||        .||
Human    68 QAQPIAWASLRLQESPRVAELTSLSDEDSGKGSQPP--------SPP------------------ 106

  Fly   184 LILHKKEHQGHMLYHCTEPGCEEAFNRFENLRQHELEHSEVGMRFVCEEEGCNRMYRHKASLKYH 248
                                 ..|.:.|.:.....|| :|....|    .|..::.:..|.|
Human   107 ---------------------SPAPSSFSSTSVSSLE-AEAYAAF----PGLGQVPKQLAQL--- 142

  Fly   249 QSKAHDIGKPLKTHMCEFCGRVFKTGSALSQHRFTHGDQLVLPYACELPECSMRFYSTEKLKIHM 313
             |:|.|: :..|...|::|.:.:.:..||..|..:|    .||..|  ..|...|.....|:.|:
Human   143 -SEAKDL-QARKAFNCKYCNKEYLSLGALKMHIRSH----TLPCVC--GTCGKAFSRPWLLQGHV 199

  Fly   314 MRHQGIKNFSCPYCGLKKTTKNELRLHINYHTLERTWSCKDCPKVCNSSTSLKKHIRAIHEKARD 378
            ..|.|.|.||||:|......::.||.|:..|:..:.:.|:.|.:..:..:.|.||        ::
Human   200 RTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKH--------QE 256

  Fly   379 YACSYCEK 386
            ..||.|.:
Human   257 SGCSGCPR 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_648046.1	zf-AD	7..80	CDD:214871
		C2H2 Zn finger	171..191	CDD:275368	0/19 (0%)
		C2H2 Zn finger	199..221	CDD:275368	3/21 (14%)
		SFP1	<228..284	CDD:227516	13/55 (24%)
		C2H2 Zn finger	230..253	CDD:275368	4/22 (18%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		C2H2 Zn finger	294..316	CDD:275368	5/21 (24%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..373	CDD:275368	5/20 (25%)
		C2H2 Zn finger	381..401	CDD:275368	3/6 (50%)
		C2H2 Zn finger	409..429	CDD:275368
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		8/23 (35%)
		SNAG domain. /evidence=ECO:0000305|PubMed:20389281, ECO:0000305|PubMed:21300290	1..20		6/16 (38%)
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:23721412	2..7		1/3 (33%)
		LATS2 binding	10..40		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..115		7/75 (9%)
		Destruction motif	95..100		0/4 (0%)
		Required for FBXL14-triggered degradation	120..151		10/40 (25%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269|PubMed:21577210, ECO:0000269|PubMed:22128911	151..264		34/126 (27%)
		C2H2 Zn finger	156..176	CDD:275368	5/19 (26%)
		C2H2 Zn finger	182..202	CDD:275368	5/21 (24%)
		zf-H2C2_2	195..218	CDD:463886	10/22 (45%)
		zf-C2H2	208..230	CDD:395048	8/21 (38%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		C2H2 Zn finger	238..255	CDD:275368	5/24 (21%)