DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10147 and ZNF581

DIOPT Version :9

Sequence 1:	NP_001261477.1	Gene:	CG10147 / 38733	FlyBaseID:	FBgn0035702	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_057619.1	Gene:	ZNF581 / 51545	HGNCID:	25017	Length:	197	Species:	Homo sapiens

Alignment Length:	238	Identity:	52/238 - (21%)
Similarity:	82/238 - (34%)	Gaps:	72/238 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 IVAEQAPPTLVFHTFTENVQQPPETEKKALEEPPLTTYKCDLCADEFREEKRLILHKKEHQG--- 193
            ::....|..|.|.: .|.::.||....::.|..|.::......:...|....|::   :.||
Human     3 VLPSPCPQPLAFSS-VETMEGPPRRTCRSPEPGPSSSIGSPQASSPPRPNHYLLI---DTQGVPY 63

  Fly   194 --------------------HMLYHCTEPGCEEAFNRFENLRQHELEHSEVGMRFVCEEEGCNRM 238
                                ...|.|  |.|...|.....|::|.:.||||
Human    64 TVLVDEESQREPGASGAPGQKKCYSC--PVCSRVFEYMSYLQRHSITHSEV-------------- 112

  Fly   239 YRHKASLKYHQSKAHDIGKPLKTHMCEFCGRVFKTGSALSQHRFTH---GDQLVLPYACELPECS 300
                              ||.:   |:.||:.||..|.|::|...|   |.:   |:.|  |.|.
Human   113 ------------------KPFE---CDICGKAFKRASHLARHHSIHLAGGGR---PHGC--PLCP 151

  Fly   301 MRFYSTEKLKIHMMRHQGIKNFSCPYCGLKKTTKNELRLHINY 343
            .||....:|..|...|.|.:.|.||:|..:...:|.|:.|..:
Human   152 RRFRDAGELAQHSRVHSGERPFQCPHCPRRFMEQNTLQKHTRW 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_001261477.1	zf-AD	7..80	CDD:214871
		C2H2 Zn finger	171..191	CDD:275368	2/19 (11%)
		zf-C2H2_8	199..287	CDD:292531	22/90 (24%)
		C2H2 Zn finger	199..221	CDD:275368	6/21 (29%)
		C2H2 Zn finger	230..253	CDD:275368	0/22 (0%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		C2H2 Zn finger	294..316	CDD:275368	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/20 (30%)
		C2H2 Zn finger	352..373	CDD:275368
		C2H2 Zn finger	381..401	CDD:275368
		C2H2 Zn finger	409..429	CDD:275368
ZNF581	NP_057619.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		9/49 (18%)
		C2H2 Zn finger	89..109	CDD:275368	6/21 (29%)
		zf-H2C2_2	101..126	CDD:404364	12/59 (20%)
		C2H2 Zn finger	117..137	CDD:275368	8/19 (42%)
		C2H2 Zn finger	147..167	CDD:275368	7/21 (33%)
		C2H2 Zn finger	175..193	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100