DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10147 and ZBTB48

DIOPT Version :9

Sequence 1:	NP_001261477.1	Gene:	CG10147 / 38733	FlyBaseID:	FBgn0035702	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001265576.1	Gene:	ZBTB48 / 3104	HGNCID:	4930	Length:	688	Species:	Homo sapiens

Alignment Length:	465	Identity:	106/465 - (22%)
Similarity:	170/465 - (36%)	Gaps:	125/465 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PSEICSECYELLEKFHSFRALCIIAD------------------------NKWRSKSLVTWKKID 90
            ||.:|.:..:.|:.       |.:.|                        |:|
Human   186 PSSLCGKLKQALKP-------CPLEDKKPEDCKVPPRPLEAEGAQLQGGSNEW------------ 231

  Fly    91 RRKPVYEVDEDEEEELELEELLLEPPEMIICDTNLSAQNTPIVAEQAPPTLVFHTFTENVQQPPE 155
              :.|.:|::|.:.:      .:..||.::.....:....|..||.|       ....::...|.
Human   232 --EVVVQVEDDGDGD------YMSEPEAVLTRRKSNVIRKPCAAEPA-------LSAGSLAAEPA 281

  Fly   156 TEKKALEEPPLTTYKCDLCADEFREEKRLILHKKEHQGHMLYHCTEPGCEEAFNRFENLRQHELE 220
            ..:|....|    .:|..|..:|..:..|.:|.::|.|...:.|  |.|.:.:.|.|||.:||..
Human   282 ENRKGTAVP----VECPTCHKKFLSKYYLKVHNRKHTGEKPFEC--PKCGKCYFRKENLLEHEAR 340

  Fly   221 H-----SEVGMRFVCEE-----------------------EGCNRMYRHKASLKYHQSKAHDIGK 257
            :     .:|....||:|                       ..|::.:..|..|:.|..|.|...|
Human   341 NCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPK 405

  Fly   258 PLKTHMCEFCGRVFKTGSALSQHR-FTH-GDQLVL--------------------------PYAC 294
            |   |.|..|.:.|.:.:.|..|. |.| |::|.:                          |:.|
Human   406 P---HACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHRNERPHVC 467

  Fly   295 ELPECSMRFYSTEKLKIHMMRHQGIKNFSCPYCGLKKTTKNELRLHINYHTLERTWSCKDCPKVC 359
            |.  ||..|.....|.:|:..|.|.|.|.|..||....|:..|..|...||.||.:||:.|.:..
Human   468 EF--CSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRF 530

  Fly   360 NSSTSLKKHIRAIHEKARDYACSYCEKKFATTDTRKYHEMTHTGEKNFECHVCGKKFIQPSALRT 424
            .....|.:|:.:.|::.|.:.|..|.|.|...:..:.|...|.|.:.|||..||.||.:.:.||.
Human   531 TEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRR 595

  Fly   425 HRKVHESGDN 434
            |.::|:..:|
Human   596 HMEIHDRVEN 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_001261477.1	zf-AD	7..80	CDD:214871	8/53 (15%)
		C2H2 Zn finger	171..191	CDD:275368	5/19 (26%)
		zf-C2H2_8	199..287	CDD:292531	30/117 (26%)
		C2H2 Zn finger	199..221	CDD:275368	9/21 (43%)
		C2H2 Zn finger	230..253	CDD:275368	7/45 (16%)
		C2H2 Zn finger	264..284	CDD:275368	6/20 (30%)
		C2H2 Zn finger	294..316	CDD:275368	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..373	CDD:275368	4/20 (20%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
ZBTB48	NP_001265576.1	BTB	16..119	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..192		3/5 (60%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		zf-H2C2_2	305..328	CDD:316026	7/24 (29%)
		C2H2 Zn finger	321..372	CDD:275368	13/52 (25%)
		SFP1	<374..459	CDD:227516	18/87 (21%)
		C2H2 Zn finger	380..401	CDD:275368	5/20 (25%)
		C2H2 Zn finger	409..425	CDD:275370	4/15 (27%)
		C2H2 Zn finger	438..459	CDD:275368	0/20 (0%)
		COG5048	<464..612	CDD:227381	48/144 (33%)
		C2H2 Zn finger	467..487	CDD:275368	7/21 (33%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
		C2H2 Zn finger	523..540	CDD:275368	3/16 (19%)
		C2H2 Zn finger	555..572	CDD:275368	4/16 (25%)
		C2H2 Zn finger	580..600	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100