DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10147 and ZNF707

DIOPT Version :9

Sequence 1:	NP_001261477.1	Gene:	CG10147 / 38733	FlyBaseID:	FBgn0035702	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001094068.1	Gene:	ZNF707 / 286075	HGNCID:	27815	Length:	371	Species:	Homo sapiens

Alignment Length:	168	Identity:	56/168 - (33%)
Similarity:	78/168 - (46%)	Gaps:	7/168 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 MCEFCGRVFKTGSALSQHRFTH-GDQLVLPYACELPECSMRFYSTEKLKIHMMRHQGIKNFSCPY 326
            :|..||:.....|.|..|:..| |.:     |.|.|||...|.....|:.|...|...|.|.|..
Human   177 ICGTCGKALSCHSRLLAHQTVHTGTK-----AFECPECGQTFRWASNLQRHQKNHTREKPFCCEA 236

  Fly   327 CGLKKTTKNELRLHINYHTLERTWSCKDCPKVCNSSTSLKKHIRAIHEKARDYACSYCEKKFATT 391
            ||...:.|:.|..|...||..|.:||.||.|.....::|.:| :.:|...|.:.|:.|.|.|.|.
Human   237 CGQAFSLKDRLAQHRKVHTEHRPYSCGDCGKAFKQKSNLLRH-QLVHTGERPFYCADCGKAFRTK 300

  Fly   392 DTRKYHEMTHTGEKNFECHVCGKKFIQPSALRTHRKVH 429
            :...:|:..|:|||.:.|..|||.|..|.....||::|
Human   301 ENLSHHQRVHSGEKPYTCAECGKSFRWPKGFSIHRRLH 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_001261477.1	zf-AD	7..80	CDD:214871
		C2H2 Zn finger	171..191	CDD:275368
		zf-C2H2_8	199..287	CDD:292531	8/24 (33%)
		C2H2 Zn finger	199..221	CDD:275368
		C2H2 Zn finger	230..253	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..316	CDD:275368	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
ZNF707	NP_001094068.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..143
		C2H2 Zn finger	178..198	CDD:275368	6/19 (32%)
		COG5048	<187..366	CDD:227381	53/158 (34%)
		C2H2 Zn finger	206..226	CDD:275368	6/19 (32%)
		zf-H2C2_2	218..242	CDD:290200	8/23 (35%)
		C2H2 Zn finger	234..254	CDD:275368	6/19 (32%)
		zf-C2H2	260..282	CDD:278523	7/22 (32%)
		C2H2 Zn finger	262..282	CDD:275368	6/20 (30%)
		zf-H2C2_2	274..299	CDD:290200	8/25 (32%)
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		zf-H2C2_2	302..325	CDD:290200	9/22 (41%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		C2H2 Zn finger	346..366	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100