DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10147 and Zfp933

DIOPT Version :9

Sequence 1:	NP_001261477.1	Gene:	CG10147 / 38733	FlyBaseID:	FBgn0035702	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_941021.1	Gene:	Zfp933 / 242747	MGIID:	1922865	Length:	468	Species:	Mus musculus

Alignment Length:	504	Identity:	129/504 - (25%)
Similarity:	187/504 - (37%)	Gaps:	135/504 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DDEAYNLLHHPYLAVKFSECTNLVVDPDDQDILPSEICSECYELLEKFHSFRALCIIADNKWRSK 81
            |..:|:.:|     |.|::...:::|| .|..|..::..|.|         |.|..|..| |.:.
Mouse     2 DAVSYDDVH-----VNFTQEEWVLLDP-SQKSLYKDVMLETY---------RNLSAIGYN-WEAH 50

  Fly    82 SLVTWKKIDRRKPVYEVDEDEEEELELEELLLEPPEMIICDTN---------------LSAQNTP 131
            ......:..||:..:|.....||..|             |:.:               :.....|
Mouse    51 PTEEHCQSSRRRGRHERSPTGEEPYE-------------CNKSGKAFAYHHYPQWHERIHTGEKP 102

  Fly   132 IVAEQAPPTLVFHT-----------------------FTENVQQPPETEKKALEEPPLTTYKCDL 173
            ....|.....|:|:                       ||.:.|..........|:|    |||:.
Mouse   103 YEVIQYGEDFVYHSSLQIYKRIAIGEKPYECNQCGKAFTYHSQLRRHKRTHTGEKP----YKCNQ 163

  Fly   174 CADEFREEKRLILHKKEHQGHMLYHCTEPGCEEAFNRFENLRQHELEHSEVGMR-FVCEEEGCNR 237
            |...|.:...||:||:.|.|...|.|.:  |.:||.....||.|:..|:  |.: :.|.:  |::
Mouse   164 CDKAFSQNGHLIIHKRTHTGEKPYECNQ--CGKAFTDQSQLRIHKRAHT--GEKPYKCNQ--CDK 222

  Fly   238 MYRHKASLKYHQSKAHDIGKPLK-------------------THM------CEFCGRVFKTGSAL 277
            .:....:|:.|: :||...||.|                   ||.      |..||:.|...|.|
Mouse   223 AFLQNINLRIHK-RAHTGEKPYKCNQCDKAFAQNGHLIIHKRTHTGEKPYECNQCGKAFADQSQL 286

  Fly   278 SQHRFTH-GDQLVLPYAC--------------------------ELPECSMRFYSTEKLKIHMMR 315
            ..||..| |::   ||.|                          |..:|...|.....||||...
Mouse   287 RIHRRIHTGEK---PYKCNQCDKAFAQHSNLRIHKRTHTGEKPYECNQCDKAFLQNINLKIHKRA 348

  Fly   316 HQGIKNFSCPYCGLKKTTKNELRLHINYHTLERTWSCKDCPKVCNSSTSLKKHIRAIHEKARDYA 380
            |.|.|::.|..||........|:.|...||.|:.:.|..|.||.:.|.||:.|.|. |...:.|.
Mouse   349 HTGEKSYECSQCGKAFARYYHLQCHERIHTEEKPYKCNQCDKVFSQSHSLQIHKRT-HTGEKPYV 412

  Fly   381 CSYCEKKFATTDTRKYHEMTHTGEKNFECHVCGKKFIQPSALRTHRKVH 429
            |:.|.|.||.....:.|:.||||||.:||:.||..|.|.|.||.|::.|
Mouse   413 CNQCGKAFADNSHLRRHKRTHTGEKPYECNQCGSAFSQNSYLRIHKRTH 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10147	NP_001261477.1	zf-AD	7..80	CDD:214871	16/62 (26%)
		C2H2 Zn finger	171..191	CDD:275368	7/19 (37%)
		zf-C2H2_8	199..287	CDD:292531	30/114 (26%)
		C2H2 Zn finger	199..221	CDD:275368	7/21 (33%)
		C2H2 Zn finger	230..253	CDD:275368	4/22 (18%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		C2H2 Zn finger	294..316	CDD:275368	8/47 (17%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..373	CDD:275368	9/20 (45%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	9/19 (47%)
Zfp933	NP_941021.1	KRAB	4..>45	CDD:214630	13/55 (24%)
		KRAB	4..40	CDD:279668	11/50 (22%)
		C2H2 Zn finger	109..125	CDD:275368	2/15 (13%)
		C2H2 Zn finger	133..153	CDD:275368	3/19 (16%)
		zf-H2C2_2	146..170	CDD:290200	7/27 (26%)
		COG5048	157..>467	CDD:227381	98/320 (31%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		zf-H2C2_2	173..197	CDD:290200	10/25 (40%)
		C2H2 Zn finger	189..209	CDD:275368	7/21 (33%)
		zf-H2C2_2	202..226	CDD:290200	7/27 (26%)
		C2H2 Zn finger	217..237	CDD:275368	4/22 (18%)
		zf-H2C2_2	229..254	CDD:290200	7/25 (28%)
		C2H2 Zn finger	245..265	CDD:275368	0/19 (0%)
		zf-H2C2_2	257..281	CDD:290200	5/23 (22%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..310	CDD:290200	8/26 (31%)
		C2H2 Zn finger	301..321	CDD:275368	1/19 (5%)
		zf-H2C2_2	313..338	CDD:290200	3/24 (13%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		zf-H2C2_2	341..366	CDD:290200	10/24 (42%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	369..394	CDD:290200	9/24 (38%)
		C2H2 Zn finger	385..405	CDD:275368	9/20 (45%)
		zf-H2C2_2	397..421	CDD:290200	9/24 (38%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		zf-H2C2_2	425..450	CDD:290200	12/24 (50%)
		C2H2 Zn finger	441..461	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100