Protein Alignment CG10163 and LPL

DIOPT Version :10

• Sequence 1: NP_648042.1
• Gene: CG10163 / 38728
• FlyBaseID: FBgn0035697
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_000228.1
• Gene: LPL / 4023
• HGNCID: 6677
• Length: 475
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 92/416 - (22%)
• Similarity: 153/416 - (36%)
• Gaps: 106/416 - (25%)

  Fly     9 KSTAQMIIAVCLICQSL-----AVEDKDKATNPLNIDSVQKHNVKLLSEQLNRGWRAFCDAPVD- 67
            :|.|.:::.:.:..|||     .|...|:..:.::|:|  |..::               .|.|
Human     2 ESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIES--KFALR---------------TPEDT 49

  Fly    68 -EGVMSLFQGINPSDARLHVMTITNQSVELPIKSISQIKDFDINPERKTLIYVNAFHTADSYFS- 130
             |....|..|:..|.|..|                       .|...||.:.::.:.....|.|
Human    50 AEDTCHLIPGVAESVATCH-----------------------FNHSSKTFMVIHGWTVTGMYESW 91

  Fly   131 VQEHLTLLQNSRRDLNVIVVDFAKDVAQLYYAVRHHLSVNGYFVYKLLRALKDA-GIAVQDITLA 194
            |.:.:..|.....|.||||||:.....:.|.....:..:.|..|.:.:..:::. ...:.::.|.
Human    92 VPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLL 156

  Fly   195 GHSVGANIAALGAQLFAKENKQLVGQLLAIDPA----------TMCRTTDILVKQSVALRVVVLH 249
            |:|:||:.|.:...|..|:    |.::..:|||          :.....|       |..|.|||
Human   157 GYSLGAHAAGIAGSLTNKK----VNRITGLDPAGPNFEYAEAPSRLSPDD-------ADFVDVLH 210

  Fly   250 -----GEGDVFGVRVPLGHIDIYPNGIGYFPRRKLQPGC------------------ESKICSHM 291
                 ..|...|::.|:||:|||||| |.|     ||||                  :...|||.
Human   211 TFTRGSPGRSIGIQKPVGHVDIYPNG-GTF-----QPGCNIGEAIRVIAERGLGDVDQLVKCSHE 269

  Fly   292 YPFILFMEALI-EGVMIPATKCESWAKFRQG---DCNFQNTINIGL-IYPANAK--GLYFCMTQP 349
            ....||:::|: |.....|.:|.|...|.:|   .|......|:|. |....||  ...:..|:.
Human   270 RSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRS 334

  Fly   350 NPPFTYMEHGLRYKARRPEKSSEKNR 375
            ..|:....:.::......|..:..|:
Human   335 QMPYKVFHYQVKIHFSGTESETHTNQ 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10163	NP_648042.1	alpha/beta hydrolases	91..349	CDD:473884	71/299 (24%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189	32..53		6/37 (16%)
		lipo_lipase	33..473	CDD:132274	85/385 (22%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	243..266		1/22 (5%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189	443..467