DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10163 and Lpl

DIOPT Version :9

Sequence 1:	NP_648042.1	Gene:	CG10163 / 38728	FlyBaseID:	FBgn0035697	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_036730.1	Gene:	Lpl / 24539	RGDID:	3017	Length:	474	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	91/377 - (24%)
Similarity:	138/377 - (36%)	Gaps:	104/377 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GWRAFCD--------APVD--EGVMSLFQGINPSDARLHVMTITNQSVELPIKSISQIKDFDINP 111
            |.|.|.|        .|.|  |....|..|:..|.:..|                       .|.
  Rat    30 GGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCH-----------------------FNH 71

  Fly   112 ERKTLIYVNAFHTADSYFS-VQEHLTLLQNSRRDLNVIVVDFAKDVAQLYYAVRHHLSVNGYF-- 173
            ..||.:.::.:.....|.| |.:.:..|.....|.||||||:      ||.|.:|:....||.
  Rat    72 SSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDW------LYRAQQHYPVSAGYTKL 130

  Fly   174 ----VYKLLRALKDA-GIAVQDITLAGHSVGANIAALGAQLFAKENKQLVGQLLAIDPA------ 227
                |.:.:..|::. ...:.::.|.|:|:||:.|.:...|..|:    |.::..:|||
  Rat   131 VGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKK----VNRITGLDPAGPNFEY 191

  Fly   228 ----TMCRTTDILVKQSVALRVVVLH-----GEGDVFGVRVPLGHIDIYPNGIGYFPRRKLQPGC 283
                :.....|       |..|.|||     ..|...|::.|:||:|||||| |.|     ||||
  Rat   192 AEAPSRLSPDD-------ADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNG-GTF-----QPGC 243

  Fly   284 ----------ESKI--------CSHMYPFILFMEALI-EGVMIPATKCESWAKFRQG---DCNFQ 326
                      |..:        |||.....||:::|: |.....|.:|.|...|.:|   .|...
  Rat   244 NIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKN 308

  Fly   327 NTINIGL-IYPANAK--GLYFCMTQPNPPFTYMEHGLRYKARRPEKSSEKNR 375
            ...|:|. |....||  ...:..|:...|:....:.::......|...:.|:
  Rat   309 RCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTENDKQNNQ 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10163	NP_648042.1	Abhydrolase	91..349	CDD:304388	77/305 (25%)
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		6/20 (30%)
		lipo_lipase	33..472	CDD:132274	89/374 (24%)
		Pancreat_lipase_like	37..334	CDD:238363	84/342 (25%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		2/22 (9%)
		PLAT_LPL	341..465	CDD:238856	2/20 (10%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010