DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10163 and Lpl

DIOPT Version :9

Sequence 1:NP_648042.1 Gene:CG10163 / 38728 FlyBaseID:FBgn0035697 Length:378 Species:Drosophila melanogaster
Sequence 2:NP_032535.2 Gene:Lpl / 16956 MGIID:96820 Length:474 Species:Mus musculus


Alignment Length:369 Identity:89/369 - (24%)
Similarity:139/369 - (37%) Gaps:79/369 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 RGWRAFCDAPVD-EGVMSLFQGINPSDARLHVMTITNQSVELPIKSISQIKDFDINPERKTLIYV 119
            ||..|..||..| ..:.|.|....|.|.       ...:..|.......:.:...|...||.:.:
Mouse    22 RGGVAAADAGRDFSDIESKFALRTPEDT-------AEDTCHLIPGLADSVSNCHFNHSSKTFVVI 79

  Fly   120 NAFHTADSYFS-VQEHLTLLQNSRRDLNVIVVDFAKDVAQLYYAVRHHLSVNGYF------VYKL 177
            :.:.....|.| |.:.:..|.....|.||||||:      ||.|.:|:....||.      |.:.
Mouse    80 HGWTVTGMYESWVPKLVAALYKREPDSNVIVVDW------LYRAQQHYPVSAGYTKLVGNDVARF 138

  Fly   178 LRALKDA-GIAVQDITLAGHSVGANIAALGAQLFAKENKQLVGQLLAIDPA----------TMCR 231
            :..:::. ...:.::.|.|:|:||:.|.:...|..|:    |.::..:|||          :...
Mouse   139 INWMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKK----VNRITGLDPAGPNFEYAEAPSRLS 199

  Fly   232 TTDILVKQSVALRVVVLH-----GEGDVFGVRVPLGHIDIYPNGIGYFPRRKLQPGC-------- 283
            ..|       |..|.|||     ..|...|::.|:||:|||||| |.|     ||||        
Mouse   200 PDD-------ADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNG-GTF-----QPGCNIGEAIRV 251

  Fly   284 ----------ESKICSHMYPFILFMEALI-EGVMIPATKCESWAKFRQG---DCNFQNTINIGL- 333
                      :...|||.....||:::|: |.....|.:|.|...|.:|   .|......|:|. 
Mouse   252 IAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYE 316

  Fly   334 IYPANAK--GLYFCMTQPNPPFTYMEHGLRYKARRPEKSSEKNR 375
            |....||  ...:..|:...|:....:.::......|...:.|:
Mouse   317 INKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTEDGKQHNQ 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10163NP_648042.1 Abhydrolase 91..349 CDD:304388 76/305 (25%)
LplNP_032535.2 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53 5/27 (19%)
lipo_lipase 33..472 CDD:132274 84/358 (23%)
Pancreat_lipase_like 37..334 CDD:238363 80/326 (25%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 1/22 (5%)
PLAT_LPL 341..465 CDD:238856 2/20 (10%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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