DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best2 and best4

DIOPT Version :9

Sequence 1:	NP_729159.2	Gene:	Best2 / 38727	FlyBaseID:	FBgn0035696	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_692160.4	Gene:	best4 / 563711	ZFINID:	ZDB-GENE-070912-6	Length:	515	Species:	Danio rerio

Alignment Length:	483	Identity:	187/483 - (38%)
Similarity:	281/483 - (58%)	Gaps:	42/483 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||||..:|.| :.||.|.|:|::|:||:|||::||.:.:..||..|:::||..|..:||.||.:
Zfish    68 MTVSYTLKVAN-AKFGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFAR 131

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :..:..:.::.|||||||||||....:|||.||...|.||.|.:.:|.   |.:|  .:|.|||:
Zfish   132 LARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSG---NVHG--TDERGRLL 191

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            ||.:|||..|:.|:.|:.||.||::||.|.:.:|:||.|...|::....|  .|..:||||||.|
Zfish   192 RRTLMRYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDELRKLNHL--YSDFNKYWMPLAW 254

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            ..|:.::|||:|.:..|..::.::.||::.|.:...|..||.:.:|||||||||:.:|::|..:|
Zfish   255 FANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSL 319

  Fly   261 LGRQMLPNVLDRSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIK 325
            :|||.   |...|..|..||:.|:||:|:|.||.|||||.|::||||||||||.|.|.||||:|:
Zfish   320 IGRQF---VKPASSEEHLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQ 381

  Fly   326 AAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAMYANIMP 390
            .:.:.||:||:..|.|.:|:||   |.|...|..||   .|....||....::.::|.......|
Zfish   382 VSMLAVDDMHQNLPPLEKDKYW---VDKGPSYPSAS---MKPVFMGSTHDMRILEDDLEECVSTP 440

  Fly   391 GGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMPFNRNRLNSVYS 455
              ..:||:.:|:.....|       :|:...::||..  ..|::.....|...|.|    :||:|
Zfish   441 --KTQMLAINVWPTTHKV-------KKSKRSLQQLCI--CCRAEGEDDCSKLEPSN----SSVHS 490

  Fly   456 SPESGLPLTILQQQQLQQAHQQQQAGSQ 483
            .          |.:.:|.:.|::..|||
Zfish   491 P----------QHKTVQHSCQEKLFGSQ 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	140/310 (45%)
best4	XP_692160.4	Bestrophin	75..380	CDD:279411	142/315 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6580
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020