DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best2 and best1

DIOPT Version :9

Sequence 1:	NP_729159.2	Gene:	Best2 / 38727	FlyBaseID:	FBgn0035696	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	XP_689098.3	Gene:	best1 / 560608	ZFINID:	ZDB-GENE-110411-214	Length:	672	Species:	Danio rerio

Alignment Length:	740	Identity:	247/740 - (33%)
Similarity:	382/740 - (51%)	Gaps:	109/740 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||:|:..|.: :..|.|:::|.:|:||:|||::|||:.:..:|..|::.||..|||.|:.:|:|
Zfish     1 MTVTYSRRVAD-ARLGTFYRLLLRWKGSIYKLLYRELLIFTVMYCIISITYRCVLTEEQRRMFEK 64

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :.||..|.::.||:||||||||.|||.|||.|:..:||||.|:..:|..:..::.|     .||:
Zfish    65 LSLYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLSALVSGHVRGADEG-----ARLI 124

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            ||::|||..|:.::..:.:|..|.:||||..|||.||||...|::..:.|  .||.:|:|:|.:|
Zfish   125 RRSLMRYANLSGILIYRSVSTAVYKRFPTMSHLVQAGLMTAEELRQLQEL--PSPHNKFWVPCMW 187

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            ..::..|||.:|.|.:|..:..||.||:.:|.:...|.|||.:.:|||||||||:.:|::|:..|
Zfish   188 FVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCL 252

  Fly   261 LGRQMLPNVLDRSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIK 325
            :|||.|.......| .:.|.:.|:||:|||.||||||||||.|||||||||||.|.|||:||:::
Zfish   253 IGRQFLDPAQGYPG-HNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQ 316

  Fly   326 AAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAMYANIMP 390
            .:.:.||||::..|.:.||:||:...|:. |||.||..:||....|||....|.||:..:.:.:
Zfish   317 VSLLSVDEMYDLVPLVERDKYWDEAEPQP-PYTAASAEHRKPSFMGSALDISVPKEEMEFQHNL- 379

  Fly   391 GGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRS----QSTAYSSGGMPFNRNRLN 451
                ..:.:...|::   .||         .:..|||:..::|    :||..|...:...|.|
Zfish   380 ----EQIKEHEEANH---STP---------FLGSLSRLLGVQSPNFPRSTPTSRVSLLRRRPR-- 426

  Fly   452 SVYSSPESGLPLTILQQQQLQQAHQQQQAGSQPSKSSLYGKFVHRKSLRAQRQLIKQNSKLNGLN 516
                :|.|..||.:..:.....:|.:....|:.:.|::  ....|....:..|     :.::.:.
Zfish   427 ----APFSRFPLYLHSESSQMPSHSRNTDVSEDAFSAM--PLYERPGFYSCPQ-----TPIHCIP 480

  Fly   517 VNVAKTRPRIPTPEVAKDGNTNPATSSVLMAPQQLSTTSAPPGM----------YPSSYAPDTLL 571
            ..|.:.|||....: :....|.|...|.::|   |..|.|||..          :|:...||
Zfish   481 PPVPRPRPRRAHGD-SSSSLTQPMVGSQILA---LPDTPAPPSSAFPWVGEDSEHPAFSFPD--- 538

  Fly   572 HQESGQVLGTLLLSPIKEMDSSSSNNTLIPGHPATAAL----------AASMKE---GFTPSSIP 623
                          |:.|: ...:...||.|.|:...|          :.|..|   .|||.|.|
Zfish   539 --------------PVPEI-CPLTKARLIQGLPSRRPLPLRLSVDKSPSPSTPERVFSFTPPSWP 588

  Fly   624 AATNITTLSFPFSVTSTGGETMPTGTLSILPISANAQLP-TITTTASGYDPNDVITTIPV----S 683
            .....|..|...:||:: ...:..||       ||...| :.::.||..:|   ::|.|.    |
Zfish   589 QTQINTASSVNVNVTNS-NNNLCNGT-------ANNPWPISRSSNASTANP---VSTSPTATQHS 642

  Fly   684 LSIQRSP--SALSIV--ELTGADVQ 704
            .:.|.||  |.:|:.  :|.||.|:
Zfish   643 ANQQNSPNDSGISLADGDLLGAAVK 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	144/310 (46%)
best1	XP_689098.3	Bestrophin	8..315	CDD:279411	145/315 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6580
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920