DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best2 and BEST2

DIOPT Version :9

Sequence 1:	NP_729159.2	Gene:	Best2 / 38727	FlyBaseID:	FBgn0035696	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_060152.2	Gene:	BEST2 / 54831	HGNCID:	17107	Length:	509	Species:	Homo sapiens

Alignment Length:	468	Identity:	195/468 - (41%)
Similarity:	269/468 - (57%)	Gaps:	46/468 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||:|...|.| :.||.|.::|..||||:|||:||||:.:|..|..::..|||.|||.|:..|:|
Human     1 MTVTYTARVAN-ARFGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEK 64

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :.:|..|.:..||:||||||||.|||.|||.||..:|.||.|...::..:..     .::.|||.
Human    65 LVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHG-----RDDRGRLY 124

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            ||.:|||..|:.|:.|:.:|..|.:||||..|:|:||.|...|.|.||.||  |..:|||:|.||
Human   125 RRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLN--SSYNKYWVPCVW 187

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            .:|:..:||::|.|..:..::.:|.||:..|.:.|.|..||.:.||||||||||:.||:||:|.|
Human   188 FSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACL 252

  Fly   261 LGRQMLPNVLDRSGREDP--DLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRH 323
            :|||.|.   ...|.:|.  ||..|:||:|||.||.|||||||.|||||||||||.|.|:||||:
Human   253 IGRQFLD---PAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRN 314

  Fly   324 IKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASE-HYRKDEPKGSAEKYKVKKEDAMYAN 387
            .:.:.:.||||:::...|.:|.||:....: .|||.|:. ..|:...:||.....:.|||..:..
Human   315 FQVSMLAVDEMYDDLAVLEKDLYWDAAEAR-APYTAATVFQLRQPSFQGSTFDITLAKEDMQFQR 378

  Fly   388 IMPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMPFNRN---- 448
            :                 :.:|.||.| ...::|.|.|.....|       .:|| |..|.
Human   379 L-----------------DGLDGPMGE-APGDFLQRLLPAGAGM-------VAGG-PLGRRLSFL 417

  Fly   449 -RLNSVYSSPESG 460
             |.||..|...:|
Human   418 LRKNSCVSEASTG 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	154/312 (49%)
BEST2	NP_060152.2	Bestrophin	8..314	CDD:279411	155/316 (49%)
BEST2	NP_060152.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920