Protein Alignment Best2 and Best4

DIOPT Version :10

• Sequence 1: NP_729159.2
• Gene: Best2 / 38727
• FlyBaseID: FBgn0035696
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001097609.1
• Gene: Best4 / 39660
• FlyBaseID: FBgn0036491
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 576
• Identity: 213/576 - (36%)
• Similarity: 313/576 - (54%)
• Gaps: 76/576 - (13%)

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||:|...|...|....|..:|.:||||:|||||.:|:.:..||..:.:.||..:.|..:..|:.
  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            |..|..:....||:||||||:|.:|:.|||:||..:||||.:|:.||.:|..|     ::..|:|
  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGS-----DDRARVM 125

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSP-MSKYWMPLV 194
            ||.|:||:.|..||....||.||||||||...:::||.:.|:|.||.||::|..| ..|:|||:|
  Fly   126 RRTILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIV 190

  Fly   195 WATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAA 259
            ||.:|:.|||::..|..|:.|:||:.||:.:|...|.|:.||.:.||||||||||:..|::|:.:
  Fly   191 WAASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFS 255

  Fly   260 LLGRQMLPNVLDRSG---REDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLID 321
            :||:|...:..|..|   |.    :||:.|||||.||:|||||||.|||||||||||.||||:||
  Fly   256 VLGQQWNESHSDEDGTRIRR----WFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIID 316

  Fly   322 RHIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSA----EKYKVKKED 382
            |::..:|.||||||:|||||::|||||.|.|.::||  |....|::.|..|.    .:.|::|.
  Fly   317 RNLTVSYCIVDEMHQEHPELVKDQYWEEVFPNEIPY--AQPKMRQNPPAASTAYMESQSKLQKR- 378

  Fly   383 AMYANIMPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMPFNR 447
                                  :||..:.:..|.:||:....|.|..:..|.|.:...
  Fly   379 ----------------------HESAMSTLSTRSRNNFRQNFLGRPSATGSYSDSIQM------- 414

  Fly   448 NRLNSVYSSPESGLPLTILQQQQLQQAHQQQQAGSQPSKSSLYGKFVHRKSLRAQRQLIK----- 507
                      |.|.......:.|....|.:..:..:||:|::....:..:..|.:|:.|:
  Fly   415 ----------EDGPSRVTFSENQFDLPHDEANSSHKPSQSTIDFNDLIEQRRRERRERIRHRFLD 469

  Fly   508 -QNSKL----NGLNVNVAKTRPRIPTPEVAKDGNTNPATSSVLMAPQQLSTTSAPP 558
             |::.|    :|....:...||  |:.|...:     :..:...|.|..|.:..||
  Fly   470 MQSTHLRHDTSGAPYTITVLRP--PSDETLSE-----SQEAGDRAQQDPSGSKEPP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..322	CDD:460047	148/312 (47%)
Best4	NP_001097609.1	Bestrophin	8..317	CDD:460047	149/317 (47%)