DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best2 and Best2

DIOPT Version :9

Sequence 1:	NP_729159.2	Gene:	Best2 / 38727	FlyBaseID:	FBgn0035696	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001102365.1	Gene:	Best2 / 364973	RGDID:	1305377	Length:	508	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	190/472 - (40%)
Similarity:	270/472 - (57%)	Gaps:	59/472 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||:|...|.| :.||.|.::|..||||:|||:||||:.:|.||..::..|||.|.|.|:..|:|
  Rat     1 MTVTYTARVAN-ARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEK 64

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :.:|..|.:..||:||||||||.|||.|||.||..:|.||.|...::..:..     .::.|||.
  Rat    65 LVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHG-----RDDRGRLY 124

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            ||.:|||..|:.|:.|:.:|..|.:||||..|:|:||.|...|.|.||.||  |..:|||:|.||
  Rat   125 RRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLN--SSYNKYWVPCVW 187

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            .:::..:||::|.|..:..::.:|.||:..|.:.|.|..||.:.:|||||||||:.:|:||:|.|
  Rat   188 FSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACL 252

  Fly   261 LGRQMLPNVLDRSGREDP--DLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRH 323
            :|||.|.   ...|.:|.  ||..|:||:|||.||.|||||||.|||||||||||.|.|:||||:
  Rat   253 IGRQFLD---PAQGYKDHTLDLCIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRN 314

  Fly   324 IKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEP--KGSAEKYKVKKEDAMY- 385
            .:.:.:.||||:::...|.:|.||:....: .|||.|:. :...:|  :||.....:.|||..:
  Rat   315 FQVSMLAVDEMYDDLAMLEKDLYWDAAEAR-APYTAATA-FLLQQPSFQGSTFDIALAKEDMQFQ 377

  Fly   386 -----------------ANIMPGG-------GKRMLSDDVYADYESVDTPMVERRKNNWLVRQLS 426
                             ..::|.|       |:|:               .:.||||: .|.:.|
  Rat   378 RLDVVDGPLGEAHGDFLQRLLPAGAGTVGPLGRRL---------------SLLRRKNS-CVSEAS 426

  Fly   427 RMGSMRSQSTAYSSGGM 443
            ...|. |.:.|...||:
  Rat   427 TAASC-SCAGAADGGGV 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	151/312 (48%)
Best2	NP_001102365.1	Bestrophin	8..314	CDD:279411	146/307 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.780