Protein Alignment Best2 and Best3

DIOPT Version :9

• Sequence 1: NP_729159.2
• Gene: Best2 / 38727
• FlyBaseID: FBgn0035696
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: XP_038935051.1
• Gene: Best3 / 314847
• RGDID: 1305439
• Length: 744
• Species: Rattus norvegicus
• Alignment Length: 680
• Identity: 234/680 - (34%)
• Similarity: 343/680 - (50%)
• Gaps: 120/680 - (17%)

  Fly    20 KILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKKIRLYFGQQSESIPMSFVLG 84
            ::|.|||||:|||::||.:.:..||..|:::||..||.:|:..|:|:.:|..:.:|.||::||||
  Rat    91 RLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGAQKRYFEKLSIYCDRYAEQIPVTFVLG 155

  Fly    85 FYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLMRRNIMRYMVLAYVITLQRI 149
            |||.|||.|||.|:..|||||.|...||:::..|     ::.|||:||.:|||:.|..::..:.:
  Rat   156 FYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGS-----DQHGRLLRRTLMRYVNLTSLLIFRSV 215

  Fly   150 SLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVWATNIINRARKDGLIASDHI 214
            |..|.:||||..|:|:||.|...|.|:|:.|  |||..|||:|.:|..|:..:||.:|.|.....
  Rat   216 STAVYKRFPTMDHVVEAGFMTADERKLFDHL--KSPHLKYWVPFIWFGNLATKARNEGRIRDSVD 278

  Fly   215 VQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAALLGRQMLPNVLDRSGREDPD 279
            :|:::.|::..|.....|.|||.|.:||||||||||.:||:|.|.|:|||.|......:| .|.|
  Rat   279 LQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAG-HDLD 342

  Fly   280 LFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIKAAYMIVDEMHEEHPELLRD 344
            |:.|:||:|||.||.|||||||.|||||||||||.|.||.|||:::.:.:.|||||...|::.:|
  Rat   343 LYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVDEMHMSLPKMKKD 407

  Fly   345 QYWECVVPKDLPYTVASEHYRKDEPKGS------------AEKYKVKKEDAMYANIMPGGGKRML 397
            .||:....:. |||:|:..|......||            ||.:....|...:.:.:....||.|
  Rat   408 IYWDDSAARP-PYTLAAADYCIPSFLGSTIQMGLSGSDFPAEDWLWNYEKQGHRHSVMRRVKRFL 471

  Fly   398 SDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMPFNRNRLNSVYSSPESGLP 462
            |     .:|...:|  :||::  ..||.|........|.|         |:.||....:|..|.|
  Rat   472 S-----THEHPGSP--KRRRS--FGRQASDSSMFFPPSPA---------RDLLNVPSRNPHRGSP 518

  Fly   463 LTILQQQQLQQAHQQQQAGSQPSKSSLYGKF--VHRKSLRAQRQLIKQNSKLNGLNVNVAKTR-P 524
            ..       :|:|.|:  || |...|..|:.  :...|..:..|.:.|.|     :|..:.|: |
  Rat   519 TR-------KQSHSQE--GS-PKLHSSMGELSTIRETSRTSTLQSLSQQS-----SVRASPTKMP 568

  Fly   525 RIP--------TPEV--AKDGNTNPATSSVL---MAPQQLSTTS---------APPG-------- 559
            ::|        .||.  |.|.:...:|:|:|   ....|.|.|.         .|||
  Rat   569 QVPEVLITAAEAPEAAFASDNHQRDSTTSILSLEFTGVQASGTEQQEDPSGKVTPPGDPEPQTIS 633

  Fly   560 -----------------MYPSSYA-PDTLLHQESGQV-LGTLLLSPIK-------EMDSSSSNNT 598
                             ::|..:: |   :.:||... ||.|...|:.       :.::||..|.
  Rat   634 AGTEKDLFKFEEDLDDDIFPKRWSLP---VFRESRHTSLGNLGPDPVSPENALLLDTETSSETNG 695

  Fly   599 LIPGHPATAALAASMKEGFTPSSIPAATNI 628
            :.||    |..|.|....:...|:...|:|
  Rat   696 VHPG----AGSAVSPDILYLMESLDKETDI 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	148/303 (49%)
Best3	XP_038935051.1	Bestrophin	91..388	CDD:395843	148/304 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.780