Protein Alignment Best2 and Best1

DIOPT Version :9

• Sequence 1: NP_729159.2
• Gene: Best2 / 38727
• FlyBaseID: FBgn0035696
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: XP_038964543.1
• Gene: Best1 / 293735
• RGDID: 1311656
• Length: 551
• Species: Rattus norvegicus
• Alignment Length: 607
• Identity: 210/607 - (34%)
• Similarity: 301/607 - (49%)
• Gaps: 100/607 - (16%)

  Fly     1 MTVSYAGEVPNG--SSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIF 63
            ||::|..||.|.  .||.|   :|.:||||:|||::.|.:.::.|||.|..:||..|:..||..|
  Rat     1 MTITYTNEVANARLGSFSC---LLLRWRGSIYKLLYGEFLVFIFLYYCIRGLYRMVLSNHQQQQF 62

  Fly    64 KKIRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGR 128
            :|:.||.....:.||:||||||||.|||.|||.||..|||||.|.:.:|:.:..     .:|.||
  Rat    63 EKLALYCNSYIQFIPISFVLGFYVTLVVSRWWNQYENLPWPDRLMMQVSSFVEG-----KDEQGR 122

  Fly   129 LMRRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDA-GLMHESEMKIFEALNQKSPMSKYWMP 192
            |:||.::||.:|..|:.|:.||..|.:|||:.|||:.| |.|...|.|..:.|.  .|.:.:|:|
  Rat   123 LLRRTLIRYAILGQVLILRSISTSVYKRFPSLQHLMQAGGFMTPGEYKQLQRLG--LPHNTFWVP 185

  Fly   193 LVWATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFI 257
            .||..|:..:|...|.|....::|:::.|:..:|.:.|.|..||.:.:|||||||||:.:|::|:
  Rat   186 WVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGHLYAYDWINIPLVYTQVVTVAVYSFFL 250

  Fly   258 AALLGRQMLPNVLDRSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDR 322
            |.|:|||.|..:.:..|.| .||..|:||:|||:||:|||||||.|||||||||||.|.||:|||
  Rat   251 ACLIGRQFLNPLKNYPGHE-MDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDR 314

  Fly   323 HIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAM--- 384
            :::.:.:.||.||.:.|.|.||.||....|:. |||.||....:....||.....:||:|:.
  Rat   315 NLQVSLLSVDGMHHDVPPLERDLYWNEAAPQP-PYTAASAGSHRQSFMGSTFNMSLKKKDSEEES 378

  Fly   385 ---------YANIMPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQST---- 436
                     |.:.: |....:.|:|.:.....:.|.::..:|:.:|..| |:....:.|..
  Rat   379 DTYDKKENDYGSTI-GRFLGLQSNDYHPPKTDLKTKLLWSKKDPFLEDQ-SKNDKQKDQKNDVWK 441

  Fly   437 --------------AYSSGGMPFNRNRLNSVYSSPESGLPLTILQQQQLQQAHQQQQAGSQPSKS 487
                          :|.....|..            |.||:....||...........|   ..|
  Rat   442 PKDLFRAIPKFKRPSYRQAPQPLG------------SHLPMVFPPQQSAPSVRYSDTGG---GPS 491

  Fly   488 SLYGKFVHRKSLRAQRQLIKQNSKLNGLNVNVAKTRPRIPT----PEVAKDGNTNPATSSVLMAP 548
            :.|.:..|.|            .|....|:|:    |..||    |.:
  Rat   492 AQYQEACHMK------------KKTVEFNLNI----PECPTEHEQPHL----------------- 523

  Fly   549 QQLSTTSAPPG-MYPSSYAPDT 569
            .|:.|....|| .||.|...||
  Rat   524 DQMHTILKEPGESYPVSDKADT 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	145/311 (47%)
Best1	XP_038964543.1	Bestrophin	8..317	CDD:395843	148/319 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780