DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best2 and Best1

DIOPT Version :9

Sequence 1:	NP_729159.2	Gene:	Best2 / 38727	FlyBaseID:	FBgn0035696	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_036043.2	Gene:	Best1 / 24115	MGIID:	1346332	Length:	551	Species:	Mus musculus

Alignment Length:	570	Identity:	205/570 - (35%)
Similarity:	293/570 - (51%)	Gaps:	100/570 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            ||::|..:|.| :..|.|..:|..||||:|||::.|.:.::.|||:|..:||..|:..||.:|:|
Mouse     1 MTITYTNKVAN-ARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEK 64

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :.||.....:.||:||||||||.|||.|||.||..|||||.|.:.:|:.:..     .:|.|||:
Mouse    65 LALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEG-----KDEEGRLL 124

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            ||.::||.:|..|:.|:.||..|.:||||..|||.||.|...|.|..:.|.  .|.:.:|:|.||
Mouse   125 RRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLG--LPHNTFWVPWVW 187

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            ..|:..:|...|.|....::|:::.|:..:|.:.|.|..||.:.:|||||||||:.:|::|:|.|
Mouse   188 FANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACL 252

  Fly   261 LGRQMLPNVLDRSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIK 325
            :|||.|....|..|.| .||..|:||:|||:||:|||||||.|||||||||||.|.||:|||:::
Mouse   253 IGRQFLNPNKDYPGHE-MDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQ 316

  Fly   326 AAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKED-------- 382
            .:.:.||.||:..|.:.||.||....|:. |||.||...|:....||.....:||||
Mouse   317 VSLLSVDGMHQNLPPMERDMYWNEAAPQP-PYTAASARSRRHSFMGSTFNISLKKEDLELWSKEE 380

  Fly   383 --------------AMYANIMPGGGKRMLSD--------------------------DVYADYES 407
                          ..:..:.|......|.|                          ||: .::.
Mouse   381 ADTDKKESGYSSTIGCFLGLQPKNYHLPLKDLKTKLLCSKNPLLEGQCKDANQKNQKDVW-KFKG 444

  Fly   408 VD----TPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMP----------------FNRNRLNS 452
            :|    .|..:||.::...:..|...:.:|..::..:|..|                ||.|
Mouse   445 LDFLKCVPRFKRRGSHCGPQAPSSHPTEQSAPSSSDTGDGPSTDYQEICHMKKKTVEFNLN---- 505

  Fly   453 VYSSPESGLPLTILQQQQLQ------QAHQQQQAGSQP------SKSSLY 490
               .|||  |...|||::|.      ||..::.|.|.|      :|..||
Mouse   506 ---IPES--PTEHLQQRRLDQMSTNIQALMKEHAESYPYRDEAGTKPVLY 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	146/310 (47%)
Best1	NP_036043.2	Bestrophin	8..315	CDD:279411	148/315 (47%)
Best1	NP_036043.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..489		4/29 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780