DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best2 and Best2

DIOPT Version :9

Sequence 1:	NP_729159.2	Gene:	Best2 / 38727	FlyBaseID:	FBgn0035696	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001123666.1	Gene:	Best2 / 212989	MGIID:	2387588	Length:	508	Species:	Mus musculus

Alignment Length:	472	Identity:	188/472 - (39%)
Similarity:	264/472 - (55%)	Gaps:	71/472 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||:|...|.| :.||.|.::|..||||:|||:||||:.:|.||..::..|||.|.|.|:..|:|
Mouse     1 MTVTYTARVAN-ARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEK 64

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :.:|..|.:..||:||||||||.|||.|||.||..:|.||.|...::..:..     .::.|||.
Mouse    65 LVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHG-----RDDRGRLY 124

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            ||.:|||..|:.|:.|:.:|..|.:||||..|:|:||.|...|.|.||.||  |..:|||:|.||
Mouse   125 RRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLN--SSYNKYWVPCVW 187

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            .:::..:||::|.|..:..::.:|.||:..|.:.|.|..||.:.:|||||||||:.:|:||:|.|
Mouse   188 FSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACL 252

  Fly   261 LGRQMLPNVLDRSGREDP--DLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRH 323
            :|||.|.   ...|.:|.  ||..|:||:|||.||.|||||||.|||||||||||.|.|:||||:
Mouse   253 IGRQFLD---PAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRN 314

  Fly   324 IKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEP--KGSAEKYKVKKEDAMYA 386
            .:.:.:.||||:::...|.:|.||:....: .|||.|:. :...:|  :||.....:.|||..:.
Mouse   315 FQVSMLAVDEMYDDLAMLEKDLYWDAAEAR-APYTAATA-FLLQQPSFQGSTFDIALAKEDMQFQ 377

  Fly   387 NIMPGGGKRMLSDDVYADYESVDTPMVE---------------------------RRKNNWLVRQ 424
            .:                 :.||.|:.|                           ||||:
Mouse   378 RL-----------------DGVDGPLGEVHGDFLQRLLPAGAGSVGPLGRRLSLLRRKNS----- 420

  Fly   425 LSRMGSMRSQSTAYSSG 441
                 .:...|||.|.|
Mouse   421 -----CVSEASTAASCG 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	151/312 (48%)
Best2	NP_001123666.1	Bestrophin	8..314	CDD:376448	146/307 (48%)
Best2	NP_001123666.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.770