Protein Alignment Best2 and best-22

DIOPT Version :10

• Sequence 1: NP_729159.2
• Gene: Best2 / 38727
• FlyBaseID: FBgn0035696
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001293988.1
• Gene: best-22 / 191197
• WormBaseID: WBGene00013921
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 585
• Identity: 184/585 - (31%)
• Similarity: 297/585 - (50%)
• Gaps: 107/585 - (18%)

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            ||:||..:| :.::...|:.:|.:|||||:|.::.:|..:..::..|:.|||:.|:.|||.:|::
 Worm     1 MTISYTLDV-SQTNLQSFFSLLLRWRGSVWKAVFGQLAVWTAVFLLISCIYRYMLSPSQQDVFEQ 64

  Fly    66 IRLYFGQQSE-SIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRL 129
            :..||..:.: :||::|:|||:|:.||.||......:.|.|..:|..:..|    .|.:.|| |:
 Worm    65 LIRYFDNKLDANIPLTFLLGFFVSFVVARWGSILNGIGWIDDASLLFATYI----RGADEET-RV 124

  Fly   130 MRRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLV 194
            :|||::||:||:..:.|:.||::|::||||...|..:|||...||.|.:.:  |.|.|:||..:.
 Worm   125 IRRNLVRYLVLSQALVLRDISMQVRKRFPTMDTLAASGLMTHEEMDILDHI--KDPYSRYWTSIQ 187

  Fly   195 WATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAA 259
            |:.|::...:|.|.:.|.:::..|:.|:...|..|..|:.||.|.|||||.||:.|.:..||:..
 Worm   188 WSLNLVYECQKKGKVDSYYLMNKIVDEIGKFRHGLASLLKYDWVPVPLVYPQVIFLAVRIYFMIC 252

  Fly   260 LLGRQMLPNVLDRSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHI 324
            |:|||.:....:.||   .||:.|:.|::||:.|:||:||||.|:||.||||||:|.|::||:::
 Worm   253 LIGRQFIVTGPNPSG---IDLWLPITTMVQFLVYMGWMKVAEALLNPLGEDDDDLECNYIIDKNL 314

  Fly   325 KAAYMIVDEM--H--------EEH----PELLRDQYWECVVPKDLP-YTVASEHYRKDEPKGSAE 374
            .....|||.|  |        |||    |...:|::|.  :.|..| |::.|.........|||.
 Worm   315 ITGLSIVDTMWKHDDTGYSMVEEHMAKTPAQKKDEFWG--IDKIAPLYSMESAERSVHPLVGSAS 377

  Fly   375 K---YKVKKEDAMYANIMPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMRSQST 436
            |   .|.|||..|                         ||    .||     :||.:..  |:..
 Worm   378 KINLVKNKKEIVM-------------------------TP----HKN-----KLSELDP--SEQK 406

  Fly   437 AYSSGGMPFNRNRLN-SVYSSPESGLPLTILQQQQLQQAHQQQQAGSQ---PSKSSLY------- 490
            .|        ..|:| |.:::..:       :|:.|::|:...:..|:   .|||.|.
 Worm   407 TY--------LRRVNVSDHNAKHA-------KQRGLERANSPDKCLSKMRSRSKSELQYIQFYEN 456

  Fly   491 GKFVHRKSLRAQRQLIKQNSKLNGLNVNVAKTRPRIPTPEVAKDGNTNPATSSVLMAPQQLSTTS 555
            |||  |.|....:..:...::...:.:|||.:.|....|.           |..:..|::..|||
 Worm   457 GKF--RTSANGSQNGVDLWTRAGDIEMNVATSNPNQVHPH-----------SIAVFPPEEQQTTS 508

  Fly   556  555
             Worm   509  508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..322	CDD:460047	120/309 (39%)
best-22	NP_001293988.1	Bestrophin	8..312	CDD:460047	121/314 (39%)