DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best2 and best-20

DIOPT Version :9

Sequence 1:	NP_729159.2	Gene:	Best2 / 38727	FlyBaseID:	FBgn0035696	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_500411.3	Gene:	best-20 / 189623	WormBaseID:	WBGene00021368	Length:	486	Species:	Caenorhabditis elegans

Alignment Length:	440	Identity:	142/440 - (32%)
Similarity:	238/440 - (54%)	Gaps:	31/440 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGL-TESQQAIFK 64
            |||||..:|.:.||.. |.::|.:|:||::|.:..||:.:...|:.|.::|...| .......|.
Worm     1 MTVSYNSDVSSVSSTN-FLRLLLRWKGSIWKSVSSELMMWCFSYFLIALLYHKVLFPNDYYDSFN 64

  Fly    65 KIRLYFGQQSES-IPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGR 128
            .:..|.|::..: ||::|:|.|:|:::|:||...:..:.|.::.||.::|.|.:     ..:..|
Worm    65 DVAFYCGKELHNYIPLTFMLAFFVSIIVERWRTTFTNMGWIESSALTVNAIIVS-----KCDEAR 124

  Fly   129 LMRRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPL 193
            |:||||:||:|||.::|.:.||:||:||||....:..||.:.::|.::.|.::  ...:|||:|:
Worm   125 LIRRNIIRYLVLAQILTFRDISIRVRRRFPNIDSIKKAGFLTDNEEELLEGID--LAYNKYWVPI 187

  Fly   194 VWATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIA 258
            .||.::.|:|...|.:.|...:.:::.|:...|..|..:..:|...:|:.|.|||...:..||:.
Worm   188 NWAISLSNQANSKGYVISAPGMVSLIQEIKTFRNGLATICNFDWCPIPIAYPQVVFFAVRIYFLF 252

  Fly   259 ALLGRQML--PNVLDRSGREDPDLFF-PLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLI 320
            .|:.||.:  ||    ...|...:|. |..|:::|:..|||:||||.|:||.||||||.|.|:||
Worm   253 CLITRQYIRVPN----KELEPVQMFIRPFITIIEFICIVGWMKVAEALLNPLGEDDDDFESNFLI 313

  Fly   321 DRHIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLP-YTVASE-HYRKDEPKGSAEKYKVKKEDA 383
            |::|.....|||:. :|.|.|..|.:.:   |..:| |:..|: :|:.....||.....:.:.|
Worm   314 DKNIFTGMRIVDQF-DEAPPLFEDTFSD---PGAMPIYSEESQKNYQNGALVGSVSNVTLAQFD- 373

  Fly   384 MYANI-MPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSRMGSMR 432
              .|| |.....|:...|:.|.    |...:.||..:...:..||..|.|
Worm   374 --ENITMVPVAPRLSIGDINAH----DRSSIRRRFKSGSSQNCSRANSFR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	107/315 (34%)
best-20	NP_500411.3	Bestrophin	8..317	CDD:279411	108/320 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720