Protein Alignment Best2 and best-3

DIOPT Version :9

• Sequence 1: NP_729159.2
• Gene: Best2 / 38727
• FlyBaseID: FBgn0035696
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_493632.1
• Gene: best-3 / 173379
• WormBaseID: WBGene00015286
• Length: 612
• Species: Caenorhabditis elegans
• Alignment Length: 735
• Identity: 225/735 - (30%)
• Similarity: 352/735 - (47%)
• Gaps: 148/735 - (20%)

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||:|:.:|.: |||.|.:|:|::|:||::|.:|.|||.:||||..::||||..||..|:|.|:.
 Worm     1 MTVTYSLDVAS-SSFFCLYKLLFRWKGSIWKSVWAELVVWLCLYAVLSVIYRCLLTMKQRATFED 64

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :.::|...|..||::|:|||||:.|..|||:.:..:.|.||..|:|:..|..     ..|..:.:
 Worm    65 LCIFFDTYSNFIPITFMLGFYVSAVFTRWWQIFDNIGWIDTPCLWITQYIKG-----ETERAKCV 124

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            |||.:||.:|...:..:.::..|::||||..|||.||||.|.||..||::  .||.:|||.|:.|
 Worm   125 RRNCIRYSILTQAMVYRDVAASVRKRFPTFNHLVTAGLMTEKEMAEFESI--PSPHAKYWQPMHW 187

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            ..::|..||.:|:|:||.|...::.::...|..:..|..:|.|.|||||||||.|.:.:||:.||
 Worm   188 LFSMITLARDEGMISSDIIYVDLMEKMRQFRVNILSLTLFDWVPVPLVYTQVVHLAVRSYFLIAL 252

  Fly   261 LGRQMLPNVLDRSG--REDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRH 323
            .|||.|....:|..  ::..||:.|:.::|||:|::||:||||||:||.||||||.|.||::||:
 Worm   253 FGRQYLHPESNRLNDFKQTIDLYVPIMSLLQFIFFIGWMKVAEVLLNPLGEDDDDFECNWILDRN 317

  Fly   324 IKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAMYANI 388
            ::...|:||..:..:|.|.:||:||..:.:.| ||.                     |.||
 Worm   318 LQVGLMVVDTAYNRYPTLEKDQFWEDAIAEPL-YTA---------------------ESAM---- 356

  Fly   389 MPGGGKRMLSDDV--YADYESVDTPMVERRKNNWLVRQLSRM----GSMRSQSTAYSSGGMPFNR 447
                  |.|:..|  .||..:.:.|.:.|.:.    |.||||    |.|.........|   ...
 Worm   357 ------RPLNPQVGSCADMPTEEEPFMVRPRR----RTLSRMSHWDGDMEDTDVVPVVG---LKH 408

  Fly   448 NRLNSVYSSPESGLPLTILQQ-----QQLQQAHQQQQAGSQPSKSSLYGKFVHRKSLRAQRQLIK 507
            .|.||.|:|.||   |.....     ::|.:..::.:|||                 |...:..|
 Worm   409 TRDNSNYASGES---LAFSNSFANGGRKLSEMFRRMRAGS-----------------RIGDRYRK 453

  Fly   508 QNSKLNGLNVNVAKTRPRIPTPEVAKDGNTNPATSSVLMAPQQLSTTSAPPGMYPSSYAPDTLLH 572
            :||........:||               .|....:..:...:|...|..|
 Worm   454 RNSSAQDFENGMAK---------------KNSIDENADIHSNRLDQASGTP-------------- 489

  Fly   573 QESGQVLGTLLLSPIKEMDSSSSNNTLIPGHPATAALAASMKEGFTPSSIPAATNITT-LSFPFS 636
             :||::..::..:.::||..:.:.|:.:..:          .:|.....:...|.||. :..|..
 Worm   490 -KSGRLWSSMPQTQLEEMLKNKNFNSPVKYN----------TDGMKDRELQNPTPITDHIDLPLH 543

  Fly   637 VTSTG---GETMPTGTLSILPISANAQLPTITTTASGYDPNDVITTIPVSLSIQRSPSALSIVEL 698
            |.|:.   .|::|     ::.....|:..:.|.|.|   |.   ::...|:||:||....|
 Worm   544 VASSQSWFNESLP-----VIKEEEEAKRKSNTDTES---PK---SSKHSSMSIRRSELRRS---- 593

  Fly   699 TGADVQDGYSNSGSSNGNGG 718
                     |:|||..|..|
 Worm   594 ---------SSSGSDLGKSG 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	137/312 (44%)
best-3	NP_493632.1	Bestrophin	8..318	CDD:279411	138/317 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I871
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I1554
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4777
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770