Protein Alignment Best2 and best-19

DIOPT Version :10

• Sequence 1: NP_729159.2
• Gene: Best2 / 38727
• FlyBaseID: FBgn0035696
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001255219.1
• Gene: best-19 / 13191891
• WormBaseID: WBGene00206487
• Length: 569
• Species: Caenorhabditis elegans
• Alignment Length: 566
• Identity: 177/566 - (31%)
• Similarity: 282/566 - (49%)
• Gaps: 83/566 - (14%)

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYR--FGLTESQQAIF 63
            |||||..:| :.:|...|.::..:|||||:|.:.|||..:...:..|..|||  :.|::.|:..:
 Worm     1 MTVSYNSDV-SSTSLIAFLRLQLRWRGSVWKSVMRELFIFSFCFAIITSIYRTNYFLSDEQRVFW 64

  Fly    64 KKIRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGR 128
            ......|.|....||::|:|||:|.::|.||.:.:..:.|.|..||.|:..|   .||  :|..|
 Worm    65 DNFAALFDQTLNYIPLTFMLGFFVTIIVGRWNDIFLNIGWVDNTALLIATYI---RGG--DEKSR 124

  Fly   129 LMRRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALN-QKSPMSKYWMP 192
            :|||..:||:||..|:..:.|||.||:||||.:.:|.:|.|.|||.:.:.||: .|.|  ||::|
 Worm   125 IMRRTALRYLVLTQVLIFRDISLVVKKRFPTLETVVASGFMLESEREKYAALSLGKYP--KYFLP 187

  Fly   193 LVWATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFI 257
            :.|..:::..||..|.|.:|.::..::..:.|.|:.||.|:.:|.|.:||||.|||.|.:..||.
 Worm   188 IQWCFSLLYDARAQGKIGADVMLNELIKSVGDFRKGLGQLLNFDWVPIPLVYPQVVFLAVRIYFF 252

  Fly   258 AALLGRQMLPNVLDRSGREDPDLFFP----LFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNW 318
            ..|:.||.:  ::|....:|....:|    |.|.|||||||||:||||.|:||.||||||.|.|:
 Worm   253 LCLIARQSV--LIDGEKPKDNSPVYPFVPFLMTSLQFVFYVGWMKVAESLMNPLGEDDDDFECNY 315

  Fly   319 LIDRHIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDA 383
            |:||::.....|||. .|..|...:|.:|...:...| |:..:.:...:...|||..|:.::.:.
 Worm   316 LLDRNLAVGLAIVDS-SEAAPHYEKDVFWGLAIADPL-YSSDTANIHINPQIGSAATYETQENEI 378

  Fly   384 MY-----ANIMPGGGKRMLSDDV----------YADYESVD------TPMVERRKNNWLVRQLSR 427
            :.     .|.|..||     |||          :....||:      |.:..||....:.|..|:
 Worm   379 IMRPHVDTNDMEDGG-----DDVEGCNPRQLSRFVSVVSVNRNCESRTSLSSRRNPTIIERLRSQ 438

  Fly   428 MGSMRSQSTAYSSGGMPFNRNRLNSVYSSPESGLPLTILQQ--QQLQQAHQ-----QQQAGS--- 482
            .|..:........|...|:   :|:.....:.|...:||.:  ::..:|.|     ::.|||
 Worm   439 FGGSKVNRPGKLFGSSQFS---INTAMGDNDIGSCASILGELAEESNKASQGLLTPEEYAGSPRR 500

  Fly   483 -----------------QPSKSSLYGKFVHRKSLRAQRQLIKQNSK 511
                             |.:::|:        .||..:::::...|
 Worm   501 NTPIDMLTSVPEEDEEAQKTRTSV--------DLRKWKEMVENEKK 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..322	CDD:460047	125/315 (40%)
best-19	NP_001255219.1	Bestrophin	8..319	CDD:460047	126/320 (39%)