DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best2 and best-19

DIOPT Version :9

Sequence 1:	NP_729159.2	Gene:	Best2 / 38727	FlyBaseID:	FBgn0035696	Length:	809	Species:	Drosophila melanogaster
Sequence 2:	NP_001255219.1	Gene:	best-19 / 13191891	WormBaseID:	WBGene00206487	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	177/566 - (31%)
Similarity:	282/566 - (49%)	Gaps:	83/566 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYR--FGLTESQQAIF 63
            |||||..:| :.:|...|.::..:|||||:|.:.|||..:...:..|..|||  :.|::.|:..:
Worm     1 MTVSYNSDV-SSTSLIAFLRLQLRWRGSVWKSVMRELFIFSFCFAIITSIYRTNYFLSDEQRVFW 64

  Fly    64 KKIRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGR 128
            ......|.|....||::|:|||:|.::|.||.:.:..:.|.|..||.|:..|   .||  :|..|
Worm    65 DNFAALFDQTLNYIPLTFMLGFFVTIIVGRWNDIFLNIGWVDNTALLIATYI---RGG--DEKSR 124

  Fly   129 LMRRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALN-QKSPMSKYWMP 192
            :|||..:||:||..|:..:.|||.||:||||.:.:|.:|.|.|||.:.:.||: .|.|  ||::|
Worm   125 IMRRTALRYLVLTQVLIFRDISLVVKKRFPTLETVVASGFMLESEREKYAALSLGKYP--KYFLP 187

  Fly   193 LVWATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFI 257
            :.|..:::..||..|.|.:|.::..::..:.|.|:.||.|:.:|.|.:||||.|||.|.:..||.
Worm   188 IQWCFSLLYDARAQGKIGADVMLNELIKSVGDFRKGLGQLLNFDWVPIPLVYPQVVFLAVRIYFF 252

  Fly   258 AALLGRQMLPNVLDRSGREDPDLFFP----LFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNW 318
            ..|:.||.:  ::|....:|....:|    |.|.|||||||||:||||.|:||.||||||.|.|:
Worm   253 LCLIARQSV--LIDGEKPKDNSPVYPFVPFLMTSLQFVFYVGWMKVAESLMNPLGEDDDDFECNY 315

  Fly   319 LIDRHIKAAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDA 383
            |:||::.....|||. .|..|...:|.:|...:...| |:..:.:...:...|||..|:.::.:.
Worm   316 LLDRNLAVGLAIVDS-SEAAPHYEKDVFWGLAIADPL-YSSDTANIHINPQIGSAATYETQENEI 378

  Fly   384 MY-----ANIMPGGGKRMLSDDV----------YADYESVD------TPMVERRKNNWLVRQLSR 427
            :.     .|.|..||     |||          :....||:      |.:..||....:.|..|:
Worm   379 IMRPHVDTNDMEDGG-----DDVEGCNPRQLSRFVSVVSVNRNCESRTSLSSRRNPTIIERLRSQ 438

  Fly   428 MGSMRSQSTAYSSGGMPFNRNRLNSVYSSPESGLPLTILQQ--QQLQQAHQ-----QQQAGS--- 482
            .|..:........|...|:   :|:.....:.|...:||.:  ::..:|.|     ::.|||
Worm   439 FGGSKVNRPGKLFGSSQFS---INTAMGDNDIGSCASILGELAEESNKASQGLLTPEEYAGSPRR 500

  Fly   483 -----------------QPSKSSLYGKFVHRKSLRAQRQLIKQNSK 511
                             |.:::|:        .||..:::::...|
Worm   501 NTPIDMLTSVPEEDEEAQKTRTSV--------DLRKWKEMVENEKK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	127/317 (40%)
best-19	NP_001255219.1	Bestrophin	8..321	CDD:279411	128/322 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I871
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4777
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720