Protein Alignment Best2 and best1

DIOPT Version :9

• Sequence 1: NP_729159.2
• Gene: Best2 / 38727
• FlyBaseID: FBgn0035696
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001155223.1
• Gene: best1 / 100302038
• XenbaseID: XB-GENE-990392
• Length: 670
• Species: Xenopus tropicalis
• Alignment Length: 666
• Identity: 230/666 - (34%)
• Similarity: 351/666 - (52%)
• Gaps: 105/666 - (15%)

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||:|:..|.: :..|.|.::|.:||||:|||::||.:.::..|:.|:|.|||.|.|.|:..|:|
 Frog     1 MTVTYSNRVAD-ARLGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEK 64

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :.||....:|.||:||||||||.|||.|||.||..:||||.|...:|:   |.:|  .:|.||::
 Frog    65 LALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSS---NVHG--TDERGRML 124

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            ||.:|||..|..::.|:.:|..|..||||.||:|:||.|..:|...|:.|  .|..:|:|:|.||
 Frog   125 RRTLMRYANLTGLLILRSVSTAVYMRFPTLQHVVNAGFMTPTERSKFDGL--VSSHNKFWVPCVW 187

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            ..|:...||.:|.|..:.::|.||.||:.:|.:.|.|.|||.:.||||||||||:.:|::|:|.|
 Frog   188 FANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACL 252

  Fly   261 LGRQMLPNVLDRSGREDPDLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIK 325
            :|||.|.......| .|.||:.|:||:|||.||.|||||||.||||||:||||.|.||||||:::
 Frog   253 IGRQFLDPQKGYPG-HDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQ 316

  Fly   326 AAYMIVDEMHEEHPELLRDQYWECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAMYANIMP 390
            .:.:.|||||::.|.|.:|.||....|:. |||.::...|:...:|||....::|||..:..:
 Frog   317 VSLLAVDEMHQDVPPLEKDIYWNDSDPQP-PYTASTVETRRPSYQGSAFDISLQKEDLEFQPL-- 378

  Fly   391 GGGKRMLSDDVYADYES-----------VDTPMVERRKNNWLVRQLSRMGSMRSQSTAYSSGGMP 444
                ..::::..|::.:           |::|..:|..:     :||.:...|::..|    |:|
 Frog   379 ----EQINENEEANHSTPLLGPLGRLLGVNSPGPQRSTS-----RLSLLMRRRNRGPA----GVP 430

  Fly   445 -FNR------------NRLNSVYSSPESGLPLTILQQQQLQQAHQQQQAGSQ---PSKSSLYGKF 493
             ||:            ..||...|:|       ..::.....|.|....|..   |.:.|.:|
 Frog   431 HFNQRDPGNIKCGEALRDLNVFMSTP-------YYERPGFYSAPQTPLNGGPTVCPPRFSTHG-- 486

  Fly   494 VHRKSLRAQRQLIKQNSKLNGLNVNVAKT---RPRIPTPEVAKDGNT-NPATSSVLMAPQQLSTT 554
                                  |..|..|   |.::|..|||.:.:: :|.:.:..:.|.. |..
 Frog   487 ----------------------NTTVFTTHWARKKVPMGEVAMESSSLSPGSKNCFVWPPG-SME 528

  Fly   555 SAPPGMYPSSYAPDTLLHQESGQVLGTL-----------LLSPIKEMDSSSSNNTL-IPGHPATA 607
            ....|:..:..:..||..:.||.:..|:           |.|.|:...:.:|.:.| .|||.|..
 Frog   529 EDVEGVISNGESVTTLQSEHSGNLQSTVQVPSKLPRALRLSSLIQGNSAQASPDALQTPGHRAPH 593

  Fly   608 ALAASMKEGFTPSSIP 623
            ::.:     |:|.:.|
 Frog   594 SIFS-----FSPVTSP 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..324	CDD:279411	153/310 (49%)
best1	NP_001155223.1	Bestrophin	8..315	CDD:376448	154/315 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010