Protein Alignment Best2 and best4

DIOPT Version :10

• Sequence 1: NP_729159.2
• Gene: Best2 / 38727
• FlyBaseID: FBgn0035696
• Length: 809
• Species: Drosophila melanogaster
• Sequence 2: NP_001116914.1
• Gene: best4 / 100144681
• XenbaseID: XB-GENE-1194400
• Length: 514
• Species: Xenopus tropicalis
• Alignment Length: 570
• Identity: 206/570 - (36%)
• Similarity: 313/570 - (54%)
• Gaps: 77/570 - (13%)

  Fly     1 MTVSYAGEVPNGSSFGCFWKILWKWRGSVYKLIWRELVAYLCLYYTINVIYRFGLTESQQAIFKK 65
            |||||..:|.| :|||||:|:|::|:||:|||:::|.:.:.|||..::|.||..|.|.|::.|.:
 Frog     1 MTVSYTLKVAN-ASFGCFFKLLFRWKGSIYKLLYKEFIVFCCLYAMLSVTYRCLLNEKQKSEFAQ 64

  Fly    66 IRLYFGQQSESIPMSFVLGFYVNLVVKRWWEQYRLLPWPDTLALFISAAIPNSNGGVNNETGRLM 130
            :..|..|.::.||:||||||||.|:|.|||.||..:|.||.|...:|:   |.:||  :|.|||:
 Frog    65 LARYCNQYTDLIPVSFVLGFYVTLIVNRWWAQYTNIPLPDQLMCVVSS---NVHGG--DERGRLL 124

  Fly   131 RRNIMRYMVLAYVITLQRISLRVKRRFPTTQHLVDAGLMHESEMKIFEALNQKSPMSKYWMPLVW 195
            ||.:|||..|:.|:.|:.:|.||.:||||.:|:|:||.|...|:|.:|.|  .|..:|||:|.||
 Frog   125 RRTMMRYANLSSVLILRSVSTRVLKRFPTMEHIVEAGFMTREELKKYECL--FSDYNKYWIPCVW 187

  Fly   196 ATNIINRARKDGLIASDHIVQTILVELSDIRRRLGGLIGYDTVCVPLVYTQVVTLVLYTYFIAAL 260
            .||:..:||:||.:..|..::.::.||:..|.:...|..||.:.||||||||||:.:|::|...:
 Frog   188 FTNLAAQARRDGRVRDDVALKLLMDELNKYRAKCSMLFHYDWISVPLVYTQVVTIAVYSFFGVCI 252

  Fly   261 LGRQMLPNVLDRSGREDP--DLFFPLFTVLQFVFYVGWLKVAEVLINPFGEDDDDIELNWLIDRH 323
            :|||.|...|:   .|.|  ||:.|:||:|||.||.||||||:.:||||||||||.|.|.||||:
 Frog   253 IGRQFLEPELE---EEKPNIDLYVPIFTLLQFFFYSGWLKVAQQIINPFGEDDDDFETNRLIDRN 314

  Fly   324 IKAAYMIVDEMHEEHPELLRDQYW--ECVVPKDLPYTVASEHYRKDEPKGSAEKYKVKKEDAMYA 386
            ::.:.:.||:|::..|.|.:|:||  :...|   |||:|:          :||..|.....:.:
 Frog   315 LQVSLLSVDDMYQNLPPLEKDKYWDDQTAAP---PYTLAT----------AAETLKPSFMGSAF- 365

  Fly   387 NIMPGGGKRMLSDDVYADYESVDTPMVERRKNNWLVRQLSR-------------MGSMRSQSTAY 438
                  ..|.|.|...:...:| ||.:.|.:...|.|.||.             .|:.......:
 Frog   366 ------DMRFLGDAEQSQQVAV-TPNMPRARTPMLSRFLSSAPSPAVSLKNFMGRGTRGHHLVRF 423

  Fly   439 SSGGMPF-NRNRLNSVYSSPESGLPLTILQQQQLQQAHQQQQAGSQPSKSSLYGKFVHRKSLRAQ 502
            ...|.|. |.|..||.......|.    :.:::..:..::.:|...|:.         :.:||..
 Frog   424 RGDGYPSPNPNSRNSDLEHDSVGR----IDEEETTEDEKESRASEPPTP---------KVTLRVP 475

  Fly   503 RQL--IKQNSKLNGLNVNVAKTRPRIPTPEVAKDGNTNPATSSVLMAPQQ 550
            |:|  .:|..|         :.:|:.|...:..|   .|:..|:...|.:
 Frog   476 RRLEASEQQKK---------REQPKPPPLVIIVD---EPSDESLNSEPAE 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best2	NP_729159.2	Bestrophin	13..322	CDD:460047	148/310 (48%)
best4	NP_001116914.1	Bestrophin	8..313	CDD:460047	150/315 (48%)