DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB11

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_011510379.1	Gene:	ABCB11 / 8647	HGNCID:	42	Length:	1355	Species:	Homo sapiens

Alignment Length:	1329	Identity:	520/1329 - (39%)
Similarity:	783/1329 - (58%)	Gaps:	63/1329 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ERDEVSTSSSEGKSQ-EEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAV 65
            |:.::|.::::.||: ::....:|:.    :.|.:|||||:..:|..:|.|.:...:..:..|.|
Human    53 EQKKISNNNNDKKSRLQDEKKGDGVR----VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGV 113

  Fly    66 VIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGI---LLTIA 127
            ::|:...|.:.:|        .:|....|...||...|.:....|.:| :.:::.|.   ||.|.
Human   114 LLIFGTMTDVFID--------YDVELQELQIPGKACVNNTIVWTNSSL-NQNMTNGTRCGLLNIE 169

  Fly   128 S-------------VVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQ 179
            |             |.:.|:|...:..:.:.|.||:.:||...|..::|.:|||.|..|......
Human   170 SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNT 234

  Fly   180 SMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGK 244
            ...||:.||.|.|::::..|:..:...|....:.|..||||||.:.|..||:.:....:.....|
Human   235 RFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSK 299

  Fly   245 LTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLK 309
            .|..|.::||.||.:|:|::||:|||.:|||||.||:|||..||.|::....||...|.....:.
Human   300 FTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVW 364

  Fly   310 SMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCA 374
            .:::|..|.|||||..|::|:     .||||..|:..|..:||||.|:...:|.||:|||.|..|
Human   365 CLIFLCYALAFWYGSTLVLDE-----GEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAA 424

  Fly   375 TNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALV 439
            |::|:.||....||.:|.||..|: .::|::||.:|.|.|||||||.:...||:.|:.|:..|||
Human   425 TSIFETIDRKPIIDCMSEDGYKLD-RIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 488

  Fly   440 GSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYG 504
            |.||.||||.:||:||||||..|.|.:|..|||..||||||..|.:|.||||||..|||:||.||
Human   489 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYG 553

  Fly   505 KPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDE 569
            :..||.::|..||.:|.|:.||.:||:.:.:::||.|.|:|||||||:|||||||:||||||||.
Human   554 REDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDM 618

  Fly   570 ATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGA 634
            ||||||.:||..||:.|.....|.|.|.|:||||.:|.||.|:....|..:|.|:|::|:..:|.
Human   619 ATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGV 683

  Fly   635 YYNMV---RAGDINMPDEVEKEDSIED---TKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPII 693
            |:.:|   ..|:..:.:| :.:|:.||   .:..|...::.|...|.....|.|.:.:..|.|:.
Human   684 YFTLVTLQSQGNQALNEE-DIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLA 747

  Fly   694 KALIKDT---NAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGE 755
            ....|.|   :.:..:.|.::........|||:.:..||.|:::|::.|...|.:.|.:|.:|.:
Human   748 VVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQ 812

  Fly   756 FYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVC----FLQTYLFNYAGIWLTTRMRAMTFNAM 816
            .....:..|.|:   :.:.::..|| |....|.|.    |||.|.|..:|..||.|:|...|.||
Human   813 ILGTFSIPDKEE---QRSQINGVCL-LFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAM 873

  Fly   817 VNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLC 881
            :.|::.||||..||.|||:.||:.:|..:|||.|..:..::.:.:|...::.:|..::|||:|:.
Human   874 LGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVI 938

  Fly   882 LANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQR 946
            |...|.:..|...:.:|::....|:||.:|...:|..|:::|||||||:.:|...|.....|:::
Human   939 LCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEK 1003

  Fly   947 VEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQS 1011
            ......||....|...:..|...|.|.:.:..|||.|:|...|.|..:.:|...::..:..|.::
Human  1004 PFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRA 1068

  Fly  1012 LAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAK 1075
            .::||:::.|.|:..|.||:|||:|.|     ::.||..::.:.|:| :.:...:|.||:|||::
Human  1069 FSYTPSYAKAKISAARFFQLLDRQPPI-----SVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQ 1128

  Fly  1076 ILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHID-HDDIQHDLTLDGVRTKLG 1139
            :||||.:.:..|||:|.||.|||||||.:|||:|:||||:|.:.|| ||  ...:.:..:|:.:|
Human  1129 VLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHD--SKKVNVQFLRSNIG 1191

  Fly  1140 IVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGG 1204
            ||||||.||..||.:||.||||.:.:.|..:|||||.|..|.|::|||..|:|.:|::|:|||.|
Human  1192 IVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRG 1256

  Fly  1205 QKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVIC 1269
            :|||||||||:||:||||||||||||||.:||:.||.|||.|..|||||||||||||:||||:|.
Human  1257 EKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIA 1321

  Fly  1270 VIQNGQVVEQGNHMQLISQGGIYAKLHKT 1298
            |:..|.|:|:|.|.:|::|.|.|.||..|
Human  1322 VMAQGVVIEKGTHEELMAQKGAYYKLVTT 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	500/1239 (40%)
		ABC_membrane	108..354	CDD:279056	87/261 (33%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	128/239 (54%)
		ABC_membrane	736..1006	CDD:279056	82/273 (30%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	138/241 (57%)
ABCB11	XP_011510379.1	PTZ00265	52..1348	CDD:240339	518/1325 (39%)
		ABC_membrane	101..405	CDD:279056	98/317 (31%)
		ABC_MTABC3_MDL1_MDL2	454..691	CDD:213216	128/236 (54%)
		ABC_membrane	794..1043	CDD:279056	78/252 (31%)
		ABC_MTABC3_MDL1_MDL2	1112..1351	CDD:213216	138/241 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3116
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860