Protein Alignment Mdr65 and MDL2

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_015053.2
• Gene: MDL2 / 855858
• SGDID: S000006191
• Length: 773
• Species: Saccharomyces cerevisiae
• Alignment Length: 762
• Identity: 212/762 - (27%)
• Similarity: 349/762 - (45%)
• Gaps: 122/762 - (16%)

  Fly     5 EVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGW------LFFGFIMCCIKALTLP 63
            |.|..|:...|:..|..|...|.::...:..:.|.....:..|      :....|.|.| .:::|
Yeast    74 ETSLPSASPISKGSARSAHAKEQSKTDDYKDIIRLFMLAKRDWKLLLTAILLLTISCSI-GMSIP 137

  Fly    64 AVVIIY---------SEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSIS 119
            .|:.|.         |:|          |.....:.:|||:                    :.:|
Yeast   138 KVIGIVLDTLKTSSGSDF----------FDLKIPIFSLPLY--------------------EFLS 172

  Fly   120 YGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDD 184
            :   .|:|.::...:......:..:::.|.|.|:|..:....:.||..:.|.....:....:..|
Yeast   173 F---FTVALLIGCAANFGRFILLRILSERVVARLRANVIKKTLHQDAEFFDNHKVGDLISRLGSD 234

  Fly   185 VEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKL---T 246
            ...:...:::||...|..::..::.|.:..|...:|::.:..:.|.|:    :.|...||.   |
Yeast   235 AYVVSRSMTQKVSDGVKALICGVVGVGMMCSLSPQLSILLLFFTPPVL----FSASVFGKQIRNT 295

  Fly   247 ARE-QESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYE---NFLVPARKASQWKGAFSGLSDAV 307
            ::: ||:......:|||.||.|:||.||..|.:|:.||.   ..:....|.:.:..|....:.::
Yeast   296 SKDLQEATGQLTRVAEEQLSGIKTVQSFVAEGNELSRYNVAIRDIFQVGKTAAFTNAKFFTTTSL 360

  Fly   308 LKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARG 372
            |..:.:|:...   ||..|::..: :...:.|..:|...:.|     :.:...:.|........|
Yeast   361 LGDLSFLTVLA---YGSYLVLQSQ-LSIGDLTAFMLYTEYTG-----NAVFGLSTFYSEIMQGAG 416

  Fly   373 CATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVA 437
            .|:.||::.|....|.|  |.|...... ||.:||:||.|.||:||.|.:.:.||.:|..|.:|.
Yeast   417 AASRLFELTDRKPSISP--TVGHKYKPD-RGVIEFKDVSFSYPTRPSVQIFKNLNFKIAPGSSVC 478

  Fly   438 LVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNIS 502
            :||.||.||||...||.|:|:|..|::.:|:.||.|.|.:.||.:|.:|.|||||..|||..||:
Yeast   479 IVGPSGRGKSTIALLLLRYYNPTTGTITIDNQDISKLNCKSLRRHIGIVQQEPVLMSGTIRDNIT 543

  Fly   503 YG---KPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKI 564
            ||   .|  |::||.:.|.|...|.|||..|.:|.::||..|:.||||||||||||||||:.|.|
Yeast   544 YGLTYTP--TKEEIRSVAKQCFCHNFITKFPNTYDTVIGPHGTLLSGGQKQRIAIARALIKKPTI 606

  Fly   565 LLLDEATSALDYQSEKQVQQALD--LASKGRTTIVVSHRLSAIRGADKIVFI-HDGKVLEEGSHD 626
            |:|||||||||.:||..:.....  :.||..|.:.::||||.||.::.::.: |||.|:|.|...
Yeast   607 LILDEATSALDVESEGAINYTFGQLMKSKSMTIVSIAHRLSTIRRSENVIVLGHDGSVVEMGKFK 671

  Fly   627 DLMA------------------------LEGAYYNMVRAGDINMP---DEVEKEDSIEDTKQKSL 664
            :|.|                        :|    .::...|:|..   |:.:|:|:.::......
Yeast   672 ELYANPTSALSQLLNEKAAPGPSDQQLQIE----KVIEKEDLNESKEHDDQKKDDNDDNDNNHDN 732

  Fly   665 ALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEK 711
            ....:|.||...|.:..:|:        ::.|:||.   :.||.|.|
Yeast   733 DSNNQSPETKDNNSDDIEKS--------VEHLLKDA---AKEANPIK 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	174/559 (31%)
		MdlB	711..1299	CDD:440747	1/1 (100%)
MDL2	NP_015053.2	3a01208	1..685	CDD:273363	194/662 (29%)