Protein Alignment Mdr65 and STE6

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_012713.1
• Gene: STE6 / 853671
• SGDID: S000001692
• Length: 1290
• Species: Saccharomyces cerevisiae
• Alignment Length: 1307
• Identity: 335/1307 - (25%)
• Similarity: 588/1307 - (44%)
• Gaps: 145/1307 - (11%)

  Fly    62 LPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSI--SYGIL- 123
            :||:       ||:|..|....        |.:|     :.|.|    ::.||...:  |..::
Yeast    40 VPAI-------TSILTGRVFDL--------LSVF-----VANGS----HQGLYSQLVQRSMAVMA 80

  Fly   124 LTIASV-VMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQ-DIGWHDLASK--QNFTQSMVDD 184
            |..||| ||::    |:..:..:..||..|:|.::..:.:.: .:.|:|...|  .:||| :...
Yeast    81 LGAASVPVMWL----SLTSWMHIGERQGFRIRSQILEAYLEEKPMEWYDNNEKLLGDFTQ-INRC 140

  Fly   185 VEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTARE 249
            ||::|...:|........:|.....:..||.|.|.|||.:....|::.......::.....:.:|
Yeast   141 VEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCSSPIITFFAVVFSRMIHVYSEKE 205

  Fly   250 QESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYL 314
            ....:.|..|....:::.:.|..:..::.|.::::..::...........|...:..:|:.:...
Yeast   206 NSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTFFIKSCFFVAANAGILRFLTLT 270

  Fly   315 SCAGAFWYGVNLIIDDR-NVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLF 378
            .....||:|..:|...: |:.:       ::..|...|:....:..|   |......:.....:.
Yeast   271 MFVQGFWFGSAMIKKGKLNIND-------VITCFHSCIMLGSTLNNT---LHQIVVLQKGGVAME 325

  Fly   379 KVIDLT---SKIDPLSTDGKL------LNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQ 434
            |::.|.   ||.:||:   |.      |:|. ..|:.|.:|.|.|||||...|.:.:::...|||
Yeast   326 KIMTLLKDGSKRNPLN---KTVAHQFPLDYA-TSDLTFANVSFSYPSRPSEAVLKNVSLNFSAGQ 386

  Fly   435 TVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQ 499
            ...:||.||.||||...||.||||...||:.::..:|:..:.:.|..||.||.|...||..|:.:
Yeast   387 FTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITVVEQRCTLFNDTLRK 451

  Fly   500 NISYGKPGATQKE----------IEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAI 554
            ||..|...:.:..          |:.|...|....||.:||:...::||..|..|||||:||:||
Yeast   452 NILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGGVTLSGGQQQRVAI 516

  Fly   555 ARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKV 619
            |||.|::..||.||||.||||......:.:|:....||:|||:::|.||.|...|.:..:.:|:|
Yeast   517 ARAFIRDTPILFLDEAVSALDIVHRNLLMKAIRHWRKGKTTIILTHELSQIESDDYLYLMKEGEV 581

  Fly   620 LEEGSHDDLMA-----------LEGAYYNMVRAGDINMPDE----VEKEDSIEDTKQKSLALFEK 669
            :|.|:..:|:|           |:..|.:.....|....::    ||..:|..:|.:....|...
Yeast   582 VESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVESFNSQLETPKLGSCLSNL 646

  Fly   670 SF-ETSPLNFEKG--QKNS------VQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLA 725
            .: ||..|:|.:.  ||.|      |:.||..|...:|......:...|:..:..:...|:::..
Yeast   647 GYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESSTGPQLLSIIQIIKRMIKSI 711

  Fly   726 KQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWA--CLGLAFLTGL 788
            :.: ..||||.:.::..|...|.|:..|......:.............:..|:  .||:|...|:
Yeast   712 RYK-KILILGLLCSLIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKWSLLVLGVAAADGI 775

  Fly   789 VCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPL 853
            ..|.:.:|.:....:....:|......:..:.:.||..|||....:||.:..:..|::..:
Yeast   776 FNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLV---- 836

  Fly   854 SGMIQALSNFISSVSV----AMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEAC 914
            |..:.|:::|::..::    |:...|||:|:|::..|:|:....:...::.......|..:.:..
Yeast   837 SEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLIIIFSAIYGGILQKCETDYKTSVAQLE 901

  Fly   915 RIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAF---FAYAVA 976
            ....:.:|||:|:..|:.|......|.:          .|::.:.:.:....|:.|   ....:.
Yeast   902 NCLYQIVTNIKTIKCLQAEFHFQLTYHD----------LKIKMQQIASKRAIATGFGISMTNMIV 956

  Fly   977 LC-------YGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDR 1034
            :|       ||..||...:...:::......||:..|.....::..|..|....|...:::|||.
Yeast   957 MCIQAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILDE 1021

  Fly  1035 KPKIQSPMGTIKNTLAKQLNLFEGVRYRG-----------IQFRYPTRPDAKILNGLDLEVLKGQ 1088
            |.....    ::|..|:.:.: .|..|.|           :.|.||:.|.|.:...::.::..||
Yeast  1022 KHNTLE----VENNNARTVGI-AGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQ 1081

  Fly  1089 TVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIA 1153
            |:.::|.||.||||.|.||.:.|:.:.|.|.||..|: :|..|..:|.::.:|.|:|.||..:|.
Yeast  1082 TLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDV-NDWNLTSLRKEISVVEQKPLLFNGTIR 1145

  Fly  1154 ENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRN 1218
            :|:.|| .:..:..:|:..|.|....|.|:||.|.|.|||:..  |.|||||.||:.|||||:|.
Yeast  1146 DNLTYG-LQDEILEIEMYDALKYVGIHDFVISSPQGLDTRIDT--TLLSGGQAQRLCIARALLRK 1207

  Fly  1219 PKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHM 1283
            .|||:|||.|||||..|..::.:.:.........:||.|....:::.:.|.|:::|:|||:||..
Yeast  1208 SKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFD 1272

  Fly  1284 QLISQGG 1290
            .|.:..|
Yeast  1273 TLYNNRG 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	150/560 (27%)
		MdlB	711..1299	CDD:440747	154/607 (25%)
STE6	NP_012713.1	MdlB	1..592	CDD:440747	159/594 (27%)
		MdlB	702..1290	CDD:440747	154/602 (26%)