DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB13

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_174115.1	Gene:	ABCB13 / 839687	AraportID:	AT1G27940	Length:	1245	Species:	Arabidopsis thaliana

Alignment Length:	1314	Identity:	473/1314 - (35%)
Similarity:	698/1314 - (53%)	Gaps:	100/1314 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SSEGKSQEEAPMAEGLE--PTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEF 72
            ||.|..|.|....|..:  ..|.::.:.||..:...:...:..|.:..||...|||...:.:.:.
plant     7 SSNGNIQAETEAKEEKKNIKKESVSLMGLFSAADKLDYFLMLLGGLGACIHGATLPLFFVFFGKM 71

  Fly    73 TSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIF 137
            ...|          .|:...|     |.:  :||...| |||         |....:|.|:|...
plant    72 LDSL----------GNLSTDP-----KAI--SSRVSQN-ALY---------LVYLGLVNFVSAWI 109

  Fly   138 SVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVY 201
            .|..:.....||..|:||....|::.:||.:.|. |...|....:..|...::|.|.:|..|.:.
plant   110 GVSCWMQTGERQTARLRINYLKSILAKDITFFDTEARDSNLIFHISSDAILVQDAIGDKTDHVLR 174

  Fly   202 LVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSS 266
            .:..||....|.|...|:|||.....:||:.:.....|.....::.:.:.:||.||.:|||::|.
plant   175 YLSQFIAGFVIGFLSVWQLTLLTLGVVPLIAIAGGGYAIVMSTISEKSETAYADAGKVAEEVMSQ 239

  Fly   267 IRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDR 331
            :|||.:|.||:..|:.|.|.|..|.|..:..|...||...:..|:|:.:.|...||...|:...:
plant   240 VRTVYAFVGEEKAVKSYSNSLKKALKLGKRSGLAKGLGVGLTYSLLFCAWALLLWYASLLVRHGK 304

  Fly   332 NVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVI-----DLTSKIDPLS 391
            ....|.:| .||.:.|.|..:|     :.||.|.:.|..|..|.|:|::|     :.:.::|
plant   305 TNGAKAFT-TILNVIFSGFALG-----QAAPSLSAIAKGRVAAANIFRMIGNNNSESSQRLD--- 360

  Fly   392 TDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRF 456
             :|..|. .:.|.:|||.|.|.|||||. :|...|:..||:|:|.|.||.||.||||.:.::|||
plant   361 -EGTTLQ-NVAGRIEFQKVSFAYPSRPN-MVFENLSFTIRSGKTFAFVGPSGSGKSTIISMVQRF 422

  Fly   457 YDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAG 521
            |:|..|.:|||..||:...::|.|..:.:|.|||.||..|||.||..||..|...:|..||..|.
plant   423 YEPNSGEILLDGNDIKSLKLKWFREQLGLVSQEPALFATTIASNILLGKENANMDQIIEAAKAAN 487

  Fly   522 AHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQAL 586
            |..||.:||..|.:.:||.|:|||||||||||||||:::|||||||||||||||.:|||.|||||
plant   488 ADSFIKSLPNGYNTQVGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAESEKIVQQAL 552

  Fly   587 DLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVE 651
            |...:.||||||:||||.||..||||.:.||:|.|.|||.:||...|.|..:|...:.. |.|..
plant   553 DNVMEKRTTIVVAHRLSTIRNVDKIVVLRDGQVRETGSHSELMLRGGDYATLVNCQETE-PQENS 616

  Fly   652 KEDSIEDTKQK----SLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKP 712
            :....|..|.:    |......|..||  :|...|:              |..|..|.:.
plant   617 RSIMSETCKSQAGSSSSRRVSSSRRTS--SFRVDQE--------------KTKNDDSKKD----- 660

  Fly   713 NFFRTFSRILQLAK---QEWCYLILGTISAVAVGFLYPAF----AVIFGEFYAALAEKDPEDALR 770
              |.:.|.|.:|.|   .||.|.:||:|.||..|...|.|    |.:...||:........| :.
plant   661 --FSSSSMIWELIKLNSPEWPYALLGSIGAVLAGAQTPLFSMGIAYVLTAFYSPFPNVIKRD-VE 722

  Fly   771 RTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALS 835
            :.|::   ..|...:|..:..||.|.:...|..||:|:|...|:|:::.|:||||.:.|:.|:|:
plant   723 KVAII---FAGAGIVTAPIYLLQHYFYTLMGERLTSRVRLSLFSAILSNEIGWFDLDENNTGSLT 784

  Fly   836 ARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMS 900
            :.|:.:|..::.|:...||.::|.||..::::::|.:|:|::|.:..|..|:::.:.:.|...:.
plant   785 SILAADATLVRSALADRLSTIVQNLSLTVTALALAFFYSWRVAAVVTACFPLLIAASLTEQLFLK 849

  Fly   901 NAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQR--VEVLIRQKLRWRGVLNS 963
            .......:....|..:|.|:|.||||||....|..:..::|.|:.:  ....:|..:...|.  .
plant   850 GFGGDYTRAYSRATSVAREAIANIRTVAAYGAEKQISEQFTCELSKPTKNAFVRGHISGFGY--G 912

  Fly   964 TMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRL 1028
            ..|..||.:||:.|.|..||::..:..|.|.||....|:..:..::::||.||.......|...:
plant   913 LSQFLAFCSYALGLWYVSVLINHKETNFGDSIKSFMVLIVTAFSVSETLALTPDIVKGTQALGSV 977

  Fly  1029 FQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVAL 1092
            |::|.|:.|| ||    ....::.::..:| :.:|.:.|.|||||:..|...|:|.|..|:::|:
plant   978 FRVLHRETKI-SP----DQPNSRMVSQVKGDIEFRNVSFVYPTRPEIDIFKNLNLRVSAGKSLAV 1037

  Fly  1093 VGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIA 1157
            ||.||.||||.:.|:.|:|||..|.:.||..||: .|.|..:|.||.:|.|||.||..:|.|||.
plant  1038 VGPSGSGKSTVIGLIMRFYDPSNGNLCIDGQDIK-TLNLRSLRKKLALVQQEPALFSTTIYENIK 1101

  Fly  1158 YGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKIL 1222
            ||:  .:.|..||:.|||:||||.|||.:..||.|..|.:|.|||||||||:|||||::::|.:|
plant  1102 YGN--ENASEAEIMEAAKAANAHEFIIKMEEGYKTHAGDKGVQLSGGQKQRVAIARAVLKDPSVL 1164

  Fly  1223 LLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS 1287
            ||||||||||..||:|||:|||....|||.:::||||||::.||.:.|:..|:|||:|:|.:|:|
plant  1165 LLDEATSALDTSSEKLVQEALDKLMKGRTTVLVAHRLSTIRKADTVAVLHKGRVVEKGSHRELVS 1229

  Fly  1288 -QGGIYAKLHKTQK 1300
             ..|.|.:|...|:
plant  1230 IPNGFYKQLTSLQE 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	455/1229 (37%)
		ABC_membrane	108..354	CDD:279056	71/246 (29%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	132/236 (56%)
		ABC_membrane	736..1006	CDD:279056	75/275 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	123/240 (51%)
ABCB13	NP_174115.1	PTZ00265	54..1241	CDD:240339	462/1263 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790