DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB11

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001322407.1	Gene:	ABCB11 / 839353	AraportID:	AT1G02520	Length:	1278	Species:	Arabidopsis thaliana

Alignment Length:	1344	Identity:	497/1344 - (36%)
Similarity:	749/1344 - (55%)	Gaps:	123/1344 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTE----PIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTL 62
            |.|.||...|..||.:|....:..|.:|    .:.|.|||.|:...::..:..|.|......::|
plant     8 EGDSVSHEPSTSKSPKEGEETKKEEKSEEKANTVPFYKLFAFADSSDVLLMICGSIGAIGNGMSL 72

  Fly    63 PAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIA 127
            |.:.:::.:    |:|   .||                     :.:||:.:.|         .::
plant    73 PFMTLLFGD----LID---SFG---------------------KNQNNKDIVD---------VVS 100

  Fly   128 SVVM-FI--------SGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQ-NFTQSMV 182
            .|.: |:        :....|..:.:...||..|:|.....:::|||||:.|:.:.. .....|.
plant   101 KVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSTYLKTILRQDIGFFDVETNTGEVVGRMS 165

  Fly   183 DDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTA 247
            .|...|:|.:.||||.|:.||..|:....::|..||.|||.:.:.|||:.:....:|....:.::
plant   166 GDTVLIQDAMGEKVGKFIQLVSTFVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASS 230

  Fly   248 REQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSML 312
            |.|.:||.|..:.|:.:.|||||.||.|||..:..|:.|:..|.|:|..:|..:||...|:..:.
plant   231 RGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGVMFFVF 295

  Fly   313 YLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNL 377
            :.|.|.|.|:|..:|::      |.||...::.....::.|:.::.:|:|.:.:||..:..|..:
plant   296 FSSYALAIWFGGKMILE------KGYTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKM 354

  Fly   378 FKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSS 442
            |:.|.....||....:||:|. .:|||:|.:||.|.||:||:..:..|.::.|.:|.|.||||.|
plant   355 FETIKRKPLIDAYDVNGKVLE-DIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGES 418

  Fly   443 GCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPG 507
            |.||||.:.|::|||||..|:||:|.::::::.::|:||.|.:|.||||||..:|.:||:|||..
plant   419 GSGKSTVISLIERFYDPKSGAVLIDGVNLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKEN 483

  Fly   508 ATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATS 572
            ||.:||:||...|.|.:||..||:...:|:||.|:|||||||||||||||::::|:|||||||||
plant   484 ATVEEIKAATELANAAKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATS 548

  Fly   573 ALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYY 636
            |||.:||:.||:|||.....|||::|:||||.:|.||.|..||.||::|:|||.:|:. .||||.
plant   549 ALDAESERVVQEALDRVMVNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYS 613

  Fly   637 NMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQK------NSVQFEEPIIKA 695
            .::|..:||           :|.|...|: ...||..|  |.:|..:      ||.:.....:..
plant   614 QLIRLQEIN-----------KDVKTSELS-SGSSFRNS--NLKKSMEGTSSVGNSSRHHSLNVLG 664

  Fly   696 LI-------------KDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYP 747
            |.             :|....:::.|..|.    :.:||..|.|.|...|:|||::|...|.::|
plant   665 LTTGLDLGSHSQRAGQDETGTASQEPLPKV----SLTRIAALNKPEIPVLLLGTVAAAINGAIFP 725

  Fly   748 AFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAF-LTGLVCF-LQTYLFNYAGIWLTTRMRA 810
            .|.::......|..:  |...|:|.:.. ||.:.:|. :|.|:.. .|.|||..||..|..|:|:
plant   726 LFGILISRVIEAFFK--PAHELKRDSRF-WAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRS 787

  Fly   811 MTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNW 875
            |.|...|:.||.|||:..||.|.:.||||.:|..|:..:|..||..:|.:::..|.:.:|...:|
plant   788 MCFEKAVHMEVAWFDEPQNSSGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASW 852

  Fly   876 KLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREY 940
            :|||:.|...|:|..:..::.|.|.......|...|||.::|.:::.:|||||....|..|::.|
plant   853 ELALIILVMLPLIGINGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMY 917

  Fly   941 TEEIQRVEVLIRQKLRWRGVLNSTMQASAFF----AYAVALCYGGVLVSEGQLPFQDIIKVSETL 1001
            .::   .|..|:..:: :|.::......:||    .||.:...|..||.:|:..|.::.:|...|
plant   918 KKQ---CEGPIKDGIK-QGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVFQVFFAL 978

  Fly  1002 LYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQS--PMGTIKNTLAKQLNLFEGVRYRGI 1064
            ...::.::||..|.|..|.|.:|...:|.|:|||.||.|  ..||:...:...:.|      |.:
plant   979 TMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIEL------RHL 1037

  Fly  1065 QFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDL 1129
            .|.||.|||.:|...|.|.:..|:||||||.||.||||.:.||||:||||.|.|.:|..::: .|
plant  1038 SFTYPARPDIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELK-KL 1101

  Fly  1130 TLDGVRTKLGIVSQEPTLFERSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTR 1193
            .|..:|.::|:|.|||.||..:|..||||| .:..:.:..||||||:.||||.||.|:..||||.
plant  1102 QLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTV 1166

  Fly  1194 MGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHR 1258
            :|.||.|||||||||:|||||:|:.||||||||||||||.:||::||.|||.....||.||:|||
plant  1167 VGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHR 1231

  Fly  1259 LSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYA---KLHKT 1298
            |||::|||||.|::||.:.|:|.|..||. :||:||   :||.|
plant  1232 LSTIKNADVIAVVKNGVIAEKGTHETLIKIEGGVYASLVQLHMT 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	474/1251 (38%)
		ABC_membrane	108..354	CDD:279056	72/255 (28%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	126/237 (53%)
		ABC_membrane	736..1006	CDD:279056	82/275 (30%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	136/245 (56%)
ABCB11	NP_001322407.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790