DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB12

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_171754.1	Gene:	ABCB12 / 839282	AraportID:	AT1G02530	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	1345	Identity:	486/1345 - (36%)
Similarity:	736/1345 - (54%)	Gaps:	130/1345 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            |.|.||...|..|:.|:|         :.:...|||.|:...::..:..|.:......:.||.:.
plant     8 EGDSVSHEHSTSKTDEKA---------KTVPLYKLFAFADSFDVFLMICGSLGAIGNGVCLPLMT 63

  Fly    67 IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVM 131
            :::.:    |:|   .||                     :.:||:.:.|         .::.|.:
plant    64 LLFGD----LID---SFG---------------------KNQNNKDIVD---------VVSKVCL 91

  Fly   132 -FI--------SGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQ-NFTQSMVDDVE 186
             |:        :....|..:.:...||..::|.....:::|||||:.|:.:.. .....|..|..
plant    92 KFVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLKTILRQDIGFFDVETNTGEVVGRMSGDTV 156

  Fly   187 KIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQE 251
            .|:|.:.||||.|:.||..|:...|::|:.||.|||.:.:.||.:.:....:|....:.::|.|.
plant   157 HIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLVTRASSRGQA 221

  Fly   252 SYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSC 316
            :||.|..:.|:.:.|||||.||.|||..:..|:.::..|.|:|..:|..:||...|:..:.:.|.
plant   222 AYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSY 286

  Fly   317 AGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVI 381
            |.|.|:|..:|::      |.||...::.....::.|:.::.:|:|.:.:||..:..|..:|:.|
plant   287 ALAIWFGGKMILE------KGYTGGSVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETI 345

  Fly   382 DLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGK 446
            .....||....:||:|. .:|||:|.:||.|.||:||:..:..|.::.|.:|.|.||||.||.||
plant   346 KRKPLIDAYDVNGKVLG-DIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGK 409

  Fly   447 STCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQK 511
            ||.:.|::|||||..|.||:|.::::::.::|:||.|.:|.||||||..:|.:||:|||..||.:
plant   410 STVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKENATLQ 474

  Fly   512 EIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDY 576
            ||:.|...|.|.:||.|||:...:.:||.|:|||||||||||||||::::|::|||||||||||.
plant   475 EIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQKQRIAIARAILKDPRVLLLDEATSALDT 539

  Fly   577 QSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVR 640
            :||:.||:|||.....|||:||:||||.:|.||.|..||.||::|:|||.:|:. ..|||..::|
plant   540 ESERVVQEALDRVMVNRTTVVVAHRLSTVRNADMIAVIHSGKMVEKGSHSELLKDSVGAYSQLIR 604

  Fly   641 AGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQK----------NSVQFEEPIIKA 695
            ..:||...:.:..|....:          ||..|.||..:...          ||.:.....:..
plant   605 CQEINKGHDAKPSDMASGS----------SFRNSNLNISREGSVISGGTSSFGNSSRHHSLNVLG 659

  Fly   696 LI--------------KDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLY 746
            |.              ::|...|.| |..|.    :.:||..|.|.|...|:|||:.|...|.::
plant   660 LFAGLDLGSGSQRVGQEETGTTSQE-PLRKV----SLTRIAALNKPEIPVLLLGTVVAAINGAIF 719

  Fly   747 PAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAF-LTGLVCF-LQTYLFNYAGIWLTTRMR 809
            |.|.::......|..:  |.|.|::.:.. ||.:.:|. :|.|:.. .|.|||..||..|..|::
plant   720 PLFGILISRVIEAFFK--PADQLKKDSRF-WAIIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQ 781

  Fly   810 AMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYN 874
            :|.|...|:.||.|||:..||.|.:.||||.:|..|:..:|..||..:|..::..|.:.:|...:
plant   782 SMCFEKAVHMEVSWFDEPENSSGTMGARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTAS 846

  Fly   875 WKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIRE 939
            |:|||:.|...|:|..:..|:.|.|.......|...|||.::|.:::.:|||||....|..|::.
plant   847 WELALIILVMLPLIGINGFLQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQM 911

  Fly   940 YTEEIQRVEVLIRQKLRWRGVLNSTMQASAFF----AYAVALCYGGVLVSEGQLPFQDIIKVSET 1000
            |.::   .|..|:..:: :|.::......:||    .||.:......||.:|:..|.|:.:|...
plant   912 YNKQ---CEGPIKDGVK-QGFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFA 972

  Fly  1001 LLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQS--PMGTIKNTLAKQLNLFEGVRYRG 1063
            |...::.::||..|.|..|.|.:|...:|.|:|||.||.|  ..||:...:...:.|      |.
plant   973 LTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIEL------RH 1031

  Fly  1064 IQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHD 1128
            :.|.||.||..:|...|.|.:..|:||||||.||.||||.:.||||:||||.|.|.:|..::: .
plant  1032 LSFTYPARPGIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELK-K 1095

  Fly  1129 LTLDGVRTKLGIVSQEPTLFERSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDT 1192
            |.|..:|.::|:|.|||.||..:|..||||| .:..:.:..||||||:.||||.||.|:..||||
plant  1096 LQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDT 1160

  Fly  1193 RMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAH 1257
            .:|.:|.|||||||||:|||||:|:.||||||||||||||.:||:|||.|||.....||.:|:||
plant  1161 VVGEKGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAH 1225

  Fly  1258 RLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYA---KLHKT 1298
            ||||::|||||.:::||.:.|.|.|..||. .||:||   :||.|
plant  1226 RLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQLHMT 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	467/1256 (37%)
		ABC_membrane	108..354	CDD:279056	70/255 (27%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	124/237 (52%)
		ABC_membrane	736..1006	CDD:279056	82/275 (30%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	133/245 (54%)
ABCB12	NP_171754.1	PTZ00265	3..1267	CDD:240339	483/1340 (36%)
		ABC_membrane	50..303	CDD:279056	74/295 (25%)
		ABC_MTABC3_MDL1_MDL2	368..606	CDD:213216	124/237 (52%)
		ABC_membrane	709..978	CDD:279056	82/275 (30%)
		ABC_MTABC3_MDL1_MDL2	1027..1267	CDD:213216	131/246 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790