DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and PGP10

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_172538.1	Gene:	PGP10 / 837611	AraportID:	AT1G10680	Length:	1227	Species:	Arabidopsis thaliana

Alignment Length:	1299	Identity:	462/1299 - (35%)
Similarity:	719/1299 - (55%)	Gaps:	105/1299 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTS 86
            ||..:....::|||||.|:.:.:...:..|.|..||...::|...|.              ||..
plant    15 AEKEKKRPSVSFLKLFSFADFYDCVLMALGSIGACIHGASVPVFFIF--------------FGKL 65

  Fly    87 SNVHALP-LFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQV 150
            .|:..|. ||         .:|.:::.     ..|.:.....|||:..|....|..:.....||.
plant    66 INIIGLAYLF---------PQEASHKV-----AKYSLDFVYLSVVILFSSWLEVACWMHTGERQA 116

  Fly   151 TRMRIKLFSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISF 214
            .::|.....|::.|||...|. .|......::..::..::|.||||||:|::.:..||...||.|
plant   117 AKIRKAYLRSMLSQDISLFDTEISTGEVISAITSEILVVQDAISEKVGNFMHFISRFIAGFAIGF 181

  Fly   215 SYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSE 279
            :..|:::|...|.:|.:.|.....|.....|..|.::||..|..:|||::.::|||.:|.||:..
plant   182 ASVWQISLVTLSIVPFIALAGGIYAFVSSGLIVRVRKSYVKANEIAEEVIGNVRTVQAFTGEEKA 246

  Fly   280 VQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILM 344
            |..|:..|.......:..|...||....|..:|:||.|...|: .::::........|....:|.
plant   247 VSSYQGALRNTYNYGRKAGLAKGLGLGSLHFVLFLSWALLIWF-TSIVVHKGIANGGESFTTMLN 310

  Fly   345 IAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQD 409
            :...|:.:|     :.||.:.:|..|...|..:|::|:..::.   .|..||.|  :.||:.|:|
plant   311 VVIAGLSLG-----QAAPDISTFMRASAAAYPIFQMIERNTED---KTGRKLGN--VNGDILFKD 365

  Fly   410 VFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKY 474
            |.|.|||||:|::...||..|.||:.|||||.||.||||.:.|::|||:|..|:|:||..|||..
plant   366 VTFTYPSRPDVVIFDKLNFVIPAGKVVALVGGSGSGKSTMISLIERFYEPTDGAVMLDGNDIRYL 430

  Fly   475 NIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGE 539
            :::|||.:|.:|.||||||..||.:||.|||..||.:||..||..:.|..||.||||.:.:.:||
plant   431 DLKWLRGHIGLVNQEPVLFATTIRENIMYGKDDATSEEITNAAKLSEAISFINNLPEGFETQVGE 495

  Fly   540 RGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSA 604
            ||.||||||||||:|:||:::||.||||||||||||.:|||.||:|||....||||:||:||||.
plant   496 RGIQLSGGQKQRISISRAIVKNPSILLLDEATSALDAESEKIVQEALDRVMVGRTTVVVAHRLST 560

  Fly   605 IRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFE 668
            :|.||.|..:..||::|.||||:|:: .:|||.:::|..:...|       ::..|....::
plant   561 VRNADIIAVVGGGKIIESGSHDELISNPDGAYSSLLRIQEAASP-------NLNHTPSLPVS--- 615

  Fly   669 KSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNA--QSAEAPPEKPNFFRTFSRILQLAKQEWCY 731
                |.||.           |.||.:.    |::  ||...|........|..|:..:.:.:|.|
plant   616 ----TKPLP-----------ELPITET----TSSIHQSVNQPDTTKQAKVTVGRLYSMIRPDWKY 661

  Fly   732 LILGTISAVAVGFLYPAFAVIFGE----FYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFL 792
            .:.||:.:...|...|.||:...:    :|  :..:..::.::|.::|  .|.| :.:|.:|..:
plant   662 GLCGTLGSFIAGSQMPLFALGIAQALVSYY--MDWETTQNEVKRISIL--FCCG-SVITVIVHTI 721

  Fly   793 QTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMI 857
            :...|...|..||.|:|...|:|::..|:||||..:|:...|::||..:|..::..:....:.::
plant   722 EHTTFGIMGERLTLRVRQKMFSAILRNEIGWFDKVDNTSSMLASRLESDATLLRTIVVDRSTILL 786

  Fly   858 QALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESIT 922
            :.|...:::..::...||:|.|:.||..|:|:...|.|...|........:...:|..:|.|||:
plant   787 ENLGLVVTAFIISFILNWRLTLVVLATYPLIISGHISEKIFMQGYGGNLSKAYLKANMLAGESIS 851

  Fly   923 NIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEG 987
            |||||.....|..|:..|::|:........::.:..|:|....|...|.:|.:||.||.:|:.:|
plant   852 NIRTVVAFCAEEKVLDLYSKELLEPSERSFRRGQMAGILYGVSQFFIFSSYGLALWYGSILMEKG 916

  Fly   988 QLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRL----FQILDRKPKIQSPMGTIKNT 1048
            ...|:.::|....|:..::::.:.||..|    .|:.|:::    |::|||:.::....|
plant   917 LSSFESVMKTFMVLIVTALVMGEVLALAP----DLLKGNQMVVSVFELLDRRTQVVGDTG----- 972

  Fly  1049 LAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYD 1112
              ::|:..|| :..:|:.|.||:|||..|.:..:|.|..|:::||||.||.|||:.:.|:.|:||
plant   973 --EELSNVEGTIELKGVHFSYPSRPDVTIFSDFNLLVPSGKSMALVGQSGSGKSSVLSLVLRFYD 1035

  Fly  1113 PDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSA 1177
            |..|.|.||..||: .|.|..:|..:|:|.|||.||..:|.|||.||  :...|..|::.|||.|
plant  1036 PTAGIIMIDGQDIK-KLKLKSLRRHIGLVQQEPALFATTIYENILYG--KEGASESEVMEAAKLA 1097

  Fly  1178 NAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQA 1242
            ||||||.|||.||.|::|.||.|:||||:||||||||:::||:||||||||||||::||::||||
plant  1098 NAHSFISSLPEGYSTKVGERGIQMSGGQRQRIAIARAVLKNPEILLLDEATSALDVESERVVQQA 1162

  Fly  1243 LDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI-SQGGIYAK---LHKTQKDH 1302
            ||.....||.:|:||||||::|:|:|.|||:|:::|||:|..|: ::.|.|:|   |.:.|:.|
plant  1163 LDRLMRDRTTVVVAHRLSTIKNSDMISVIQDGKIIEQGSHNILVENKNGPYSKLISLQQRQRHH 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	443/1226 (36%)
		ABC_membrane	108..354	CDD:279056	63/246 (26%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	134/237 (57%)
		ABC_membrane	736..1006	CDD:279056	70/273 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	128/243 (53%)
PGP10	NP_172538.1	PTZ00265	40..1221	CDD:240339	452/1267 (36%)
		ABC_membrane	50..313	CDD:279056	72/291 (25%)
		ABC_MTABC3_MDL1_MDL2	361..599	CDD:213216	134/237 (57%)
		ABC_membrane	666..935	CDD:279056	70/273 (26%)
		ABC_MTABC3_MDL1_MDL2	982..1220	CDD:213216	127/240 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.790