Protein Alignment Mdr65 and Abcb11

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_113948.1
• Gene: Abcb11 / 83569
• RGDID: 619930
• Length: 1321
• Species: Rattus norvegicus
• Alignment Length: 1336
• Identity: 520/1336 - (38%)
• Similarity: 782/1336 - (58%)
• Gaps: 99/1336 - (7%)

  Fly    10 SSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTS 74
            :::.||:.:..|.||   ...:.|.:|||||:..:|..:..|.:...:..:..|.::||:...|.
  Rat    27 NNDKKSRLQDKMKEG---DIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTD 88

  Fly    75 MLVDRAMQFGTSSNVHALPLFGGGKTLT-------NASREEN-------------NEALYDDSIS 119
            :.:    ::........:|    ||...       |:|..:|             :|.:....|.
  Rat    89 IFI----KYDIERQELEIP----GKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIY 145

  Fly   120 YGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDD 184
            .|:.:|:     .|.|.|.:.::.:...||:.|||...|..::|.:|||.|..|.........||
  Rat   146 AGVGMTV-----LILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADD 205

  Fly   185 VEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLV----ILLNYYVAKFQGKL 245
            :|||.|.|::::.||:..:...:..:.:.|..||||||.:.:..||:    .::...:|||
  Rat   206 IEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKF---- 266

  Fly   246 TAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKS 310
            |..|.::||.||::|:|:|||||||.:||||..||:|||..||.|::...|||...|.....:..
  Rat   267 TELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWC 331

  Fly   311 MLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCAT 375
            :::...|.|||||..|::|:     :||||..|:..|..:|:.|.||...:..||.|:|....||
  Rat   332 LIFFCYALAFWYGSTLVLDE-----EEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAAT 391

  Fly   376 NLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVG 440
            |:|:.||....||.:|.||..|: .::|::||.:|.|.|||||:|.:...|::.|:.|:|.||||
  Rat   392 NIFQTIDRQPVIDCMSGDGYKLD-RIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVG 455

  Fly   441 SSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGK 505
            |||.||||.:||:||||||..|.|.||..|||..||:|||..|.:|.||||||..|||:||.:|:
  Rat   456 SSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGR 520

  Fly   506 PGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEA 570
            ..||.::|..||..|.|:.||..||:.:.:::||.|.|:|||||||:|||||||:||||||||.|
  Rat   521 EDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMA 585

  Fly   571 TSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAY 635
            |||||.:||.:||:||:....|.|.|.|:||||.:|.||.|:....|..:|.|:|::|:..:|.|
  Rat   586 TSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVY 650

  Fly   636 YNMVRAGDINMPDEVEKEDSI--EDTKQK-------SLALFEKSFETSPLNFEKGQKNSVQFEEP 691
            :.:|...  :..|...||.||  :|..:.       |...:..|...|.....|.|.:.:..:.|
  Rat   651 FMLVTLQ--SQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQLSLLTHDPP 713

  Fly   692 II----KALIKDTN-----AQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYP 747
            :.    |:..||:.     .:..|..|.:        |||:....||.|:::|::||...|.:.|
  Rat   714 LAVADHKSSYKDSKDNDVLVEEVEPAPVR--------RILKYNIPEWHYILVGSLSAAINGAVTP 770

  Fly   748 AFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVC------FLQTYLFNYAGIWLTT 806
            .::::|.:.....:..|.|.  :|:.:.| .||   |...|.|      |||.|.|..:|..||.
  Rat   771 IYSLLFSQLLGTFSLLDKEQ--QRSEIHS-MCL---FFVILGCVSIFTQFLQGYTFAKSGELLTK 829

  Fly   807 RMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAM 871
            |:|...|.||:.|::|||||..|:.|.|:.||:.:|..:|||.|..:..|:.:.:|.|:::.:|.
  Rat   830 RLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAF 894

  Fly   872 YYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADV 936
            :::|||:|:.....|.:..|..::.||::....::||.:|:|.:|.:|:::|||||||:..|...
  Rat   895 FFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRF 959

  Fly   937 IREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETL 1001
            |:.:..|:|.......:|....|:..:..|..||.|.:.|..|||.|::...|.|..:.:|..::
  Rat   960 IKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSV 1024

  Fly  1002 LYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQ 1065
            ...:..:.::.::||:::.|.|:..|.||:|||||.|     .:.:...::.:.|:| :.:...:
  Rat  1025 ALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPI-----NVYSEAGEKWDNFQGKIDFIDCK 1084

  Fly  1066 FRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHID-HDDIQHDL 1129
            |.||:|||.::||||.:.|..|||:|.||.|||||||.:|||:|:||||:||:.|| ||  ...:
  Rat  1085 FTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHD--SKKV 1147

  Fly  1130 TLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRM 1194
            .:..:|:.:|||||||.||:.||.:||.||||.:.:|:...|||||.|..|.|::|||..|:|.:
  Rat  1148 NIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNV 1212

  Fly  1195 GARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRL 1259
            |.:|:|||.|:|||||||||:||:||||||||||||||.:||:.||.|||.|..|||||||||||
  Rat  1213 GIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRL 1277

  Fly  1260 STVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
            ||:||:|:|.|:..|.|:|:|.|.:|::|.|.|.||
  Rat  1278 STIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKL 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	503/1255 (40%)
		ABC_membrane	108..354	CDD:279056	87/262 (33%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	128/236 (54%)
		ABC_membrane	736..1006	CDD:279056	86/275 (31%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	138/238 (58%)
Abcb11	NP_113948.1	PTZ00265	150..1314	CDD:240339	494/1202 (41%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385	651..674		6/24 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3071
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730