DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB7

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_199466.1	Gene:	ABCB7 / 834697	AraportID:	AT5G46540	Length:	1248	Species:	Arabidopsis thaliana

Alignment Length:	1291	Identity:	484/1291 - (37%)
Similarity:	717/1291 - (55%)	Gaps:	94/1291 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLF 95
            |||.|||.|:...:|..:..|.:......||.|.:.|:..:..::       ||.|.:.|..
plant    18 IAFYKLFTFADRYDIVLMVIGTLSAMANGLTQPFMSILMGQLINV-------FGFSDHDHVF--- 72

  Fly    96 GGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSS 160
                      :|.:..|     :.:..|...|.||.|:    .|..:.:...||.||:|.....:
plant    73 ----------KEVSKVA-----VKFLYLAAYAGVVSFL----QVSCWMVTGERQSTRIRRLYLKT 118

  Fly   161 VIRQDIGWHDLASKQ-NFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAV 224
            ::|||||:.|..:.. .....|..|...|:|.:.||||.|..||..|:....::|..|.|||||:
plant   119 ILRQDIGFFDTETNTGEVIGRMSGDTILIQDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTLAL 183

  Fly   225 SSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVP 289
            ...:||::.....:.....|...|.|.:|..|||:.::.:.||||||:|.|||..:.:||..|..
plant   184 LPCVPLIVGTGGAMTYIMSKKAQRVQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGKYEKKLEI 248

  Fly   290 ARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGA 354
            |.|:...:|.:|||...::..::|.:...|.|||...||:      |.||...:|.....|:.|.
plant   249 AYKSMVKQGLYSGLGIGIMMVVVYCTYGFAIWYGARQIIE------KGYTGGQVMNVITSILTGG 307

  Fly   355 DNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPE 419
            ..:.:|.|.|.|||.....|..:|:.|....|||.....|::|. .::||:|.:||:||||:||:
plant   308 MALGQTLPSLNSFAAGTAAAYKMFETIKRKPKIDAYDMSGEVLE-EIKGDIELRDVYFRYPARPD 371

  Fly   420 VIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIA 484
            |.:..|.::.:..|.||||||.||.||||.:.|::|||||..|.||:|.:|::|:.::|:||.|.
plant   372 VQIFVGFSLTVPNGMTVALVGQSGSGKSTVISLIERFYDPESGEVLIDGIDLKKFQVKWIRSKIG 436

  Fly   485 VVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQK 549
            :|.|||:||..||.:||.|||..|:.:||..|...|.|..||..||:...:|:||.|:|||||||
plant   437 LVSQEPILFATTIRENIVYGKKDASDQEIRTALKLANASNFIDKLPQGLETMVGEHGTQLSGGQK 501

  Fly   550 QRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFI 614
            ||||||||:::|||||||||||||||.:||:.||.||......|||:||:|||:.||.||.|..:
plant   502 QRIAIARAILKNPKILLLDEATSALDAESERIVQDALVKLMLSRTTVVVAHRLTTIRTADMIAVV 566

  Fly   615 HDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNF 678
            ..|||:|:|:||:::. .||.|..:||     :.:..:||::|:...:|.    |.|.|....:.
plant   567 QQGKVIEKGTHDEMIKDPEGTYSQLVR-----LQEGSKKEEAIDKEPEKC----EMSLEIESSDS 622

  Fly   679 EKGQKNSV--------------QFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEW 729
            :.|..:..              |.||  ....|..|..|:.:...|.     :..|:..|.|.|.
plant   623 QNGIHSGTLTSPSGLPGVISLDQTEE--FHENISSTKTQTVKKGKEV-----SLRRLAHLNKPEI 680

  Fly   730 CYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAF-LTGLVCF-L 792
            ..|:||:::||..|.::|...::.........|  |.:.|:..: |.||.:.:|. ||.|:.. |
plant   681 SVLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFE--PSNKLKNDS-LFWALIFVALGLTDLIVIPL 742

  Fly   793 QTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMI 857
            |.|||..||..|..|:|:::|:.:::|::.||||..||.|.:.||||.:|..::..:|..|..::
plant   743 QNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTKNSSGVIGARLSTDASTVKSIVGDVLGLIM 807

  Fly   858 QALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESIT 922
            |.::..|.:..:|...||.|||:.|...|::......:.|.::....:.:...|||.::|:::::
plant   808 QNMATIIGAFIIAFTANWLLALMALLVAPVMFFQGYYQIKFITGFGAKARGKYEEASQVASDAVS 872

  Fly   923 NIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAV--ALCY--GGVL 983
            :|||||....|..|:..|.|:....    :|:....|:::......::.|..|  ::|:  |..|
plant   873 SIRTVASFCAEDKVMDLYQEKCDEP----KQQGFKLGLVSGLCYGGSYLALYVIESVCFLGGSWL 933

  Fly   984 VSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI--QSPMGTIK 1046
            :...:..|.:..:|...|...::.:.|:....|..:.|..:...:|.|||.||||  .|..|||
plant   934 IQNRRATFGEFFQVFFALTLTAVGVTQTSTMAPDINKAKDSAASIFDILDSKPKIDSSSEKGTI- 997

  Fly  1047 NTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRY 1110
                  |.:..| :..:.:.||||.|||.:|.:.|.|.:..||||||||.||.||||.:.||:|:
plant   998 ------LPIVHGDIELQHVSFRYPMRPDIQIFSDLCLTISSGQTVALVGESGSGKSTVISLLERF 1056

  Fly  1111 YDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAK 1175
            ||||.|.|.:|..:|| .|.|..:|.::|:|||||.||..:|..||||| .....:..|||.|||
plant  1057 YDPDSGKILLDQVEIQ-SLKLSWLREQMGLVSQEPVLFNETIGSNIAYG-KIGGATEEEIITAAK 1119

  Fly  1176 SANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQ 1240
            :||.|:||.|||.||:|.:|.||.|||||||||||||||::::||||||||||||||.:||::||
plant  1120 AANVHNFISSLPQGYETSVGERGVQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQ 1184

  Fly  1241 QALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYAKL 1295
            .|||.....||.:|:||.|:|:::||:|.|::||.:.|.|.|..|:. .||.||.|
plant  1185 DALDQVMVNRTTVVVAHLLTTIKDADMIAVVKNGVIAESGRHETLMEISGGAYASL 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	467/1231 (38%)
		ABC_membrane	108..354	CDD:279056	77/246 (31%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	128/237 (54%)
		ABC_membrane	736..1006	CDD:279056	74/275 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	131/238 (55%)
ABCB7	NP_199466.1	PTZ00265	16..1241	CDD:240339	484/1291 (37%)
		ABC_membrane	39..308	CDD:279056	87/303 (29%)
		ABC_MTABC3_MDL1_MDL2	357..595	CDD:213216	128/242 (53%)
		ABC_membrane	688..956	CDD:279056	74/274 (27%)
		ABC_MTABC3_MDL1_MDL2	1005..1241	CDD:213216	131/238 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790