DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB2

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_194326.2	Gene:	ABCB2 / 828702	AraportID:	AT4G25960	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	1304	Identity:	459/1304 - (35%)
Similarity:	723/1304 - (55%)	Gaps:	96/1304 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SQEEAPMAEGLEPTEP-IAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVD 78
            |.:.||..| .|.|:| ::.||||.|:.:.:...:..|.:..||...::|...|.:.:..:::
plant    44 SGDPAPEKE-KEMTQPKVSLLKLFSFADFYDCVLMTLGSVGACIHGASVPIFFIFFGKLINII-- 105

  Fly    79 RAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFN 143
                               |.......:..:..|.|.....|      .||.:..|....|..:.
plant   106 -------------------GLAYLFPKQASHRVAKYSLDFVY------LSVAILFSSWLEVACWM 145

  Fly   144 MVALRQVTRMRIKLFSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFI 207
            ....||..:||.....|::.|||...|. ||......::..|:..::|.:|||||:|::.:..||
plant   146 HTGERQAAKMRRAYLRSMLSQDISLFDTEASTGEVISAITSDILVVQDALSEKVGNFLHYISRFI 210

  Fly   208 ITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVS 272
            ...||.|:..|:::|...|.:||:.|.....|.....|.||.::||..||.:|||::.::|||.:
plant   211 AGFAIGFTSVWQISLVTLSIVPLIALAGGIYAFVAIGLIARVRKSYIKAGEIAEEVIGNVRTVQA 275

  Fly   273 FGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKE 337
            |.||:..|:.|...|....|..:..|...||....:..:|:||.|...|:...::..|.....|.
plant   276 FTGEERAVRLYREALENTYKYGRKAGLTKGLGLGSMHCVLFLSWALLVWFTSVVVHKDIADGGKS 340

  Fly   338 YTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLR 402
            :|      ....:::...::.:.||.:.:|..|:..|..:||:|:..:.....:..|:.|. .:.
plant   341 FT------TMLNVVIAGLSLGQAAPDISAFVRAKAAAYPIFKMIERNTVTKTSAKSGRKLG-KVD 398

  Fly   403 GDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLD 467
            |.::|:|..|.|||||:|::...||:.|.||:.|||||.||.||||.:.|::|||:|:.|:||||
plant   399 GHIQFKDATFSYPSRPDVVIFDRLNLAIPAGKIVALVGGSGSGKSTVISLIERFYEPISGAVLLD 463

  Fly   468 DLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPES 532
            ..:|.:.:|:|||..|.:|.|||.||..||.:||.|||..||.:||..||..:.|..||.||||.
plant   464 GNNISELDIKWLRGQIGLVNQEPALFATTIRENILYGKDDATAEEITRAAKLSEAISFINNLPEG 528

  Fly   533 YRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIV 597
            :.:.:||||.||||||||||||:||:::||.||||||||||||.:|||.||:|||....||||:|
plant   529 FETQVGERGIQLSGGQKQRIAISRAIVKNPSILLLDEATSALDAESEKSVQEALDRVMVGRTTVV 593

  Fly   598 VSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQ 661
            |:||||.:|.||.|..:|:||::|.|:|::|:: .:|||.:::|               :::|
plant   594 VAHRLSTVRNADIIAVVHEGKIVEFGNHENLISNPDGAYSSLLR---------------LQET-- 641

  Fly   662 KSLALFEKSFETSP-LNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFR----TFSRI 721
                   .|.:.:| ||....:.:|:::...:.:......:.:.:...|:..:..:    |..|:
plant   642 -------ASLQRNPSLNRTLSRPHSIKYSRELSRTRSSFCSERESVTRPDGADPSKKVKVTVGRL 699

  Fly   722 LQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGE----FYAALAEKDPEDALRRTAVLSWACLGL 782
            ..:.:.:|.|.:.|||.|...|...|.||:...:    :|:...|...|  :::.|:| :.|..:
plant   700 YSMIRPDWMYGVCGTICAFIAGSQMPLFALGVSQALVSYYSGWDETQKE--IKKIAIL-FCCASV 761

  Fly   783 AFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQG 847
              :|.:|..::...|...|..||.|:|...|.|::..|:||||:.:|:...|::||..:|..::.
plant   762 --ITLIVYTIEHICFGTMGERLTLRVRENMFRAILKNEIGWFDEVDNTSSMLASRLESDATLLKT 824

  Fly   848 AIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEE 912
            .:....:.::|.|...::|..:|...||:|.|:.||..|:::...|.|...|........:...:
plant   825 IVVDRSTILLQNLGLVVTSFIIAFILNWRLTLVVLATYPLVISGHISEKLFMQGYGGDLNKAYLK 889

  Fly   913 ACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVAL 977
            |..:|.||::||||||....|..::..|:.|:........::.:..|:.....|...|.:|.:||
plant   890 ANMLAGESVSNIRTVAAFCAEEKILELYSRELLEPSKSSFRRGQIAGLFYGVSQFFIFSSYGLAL 954

  Fly   978 CYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRL----FQILDRKPKI 1038
            .||..|:.:|...|:.::|....|:..::.:.::||..|    .|:.|:::    |:|||||.:|
plant   955 WYGSTLMDKGLAGFKSVMKTFMVLIVTALAMGETLALAP----DLLKGNQMVASVFEILDRKTQI 1015

  Fly  1039 QSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKST 1102
                  :..| :::||..|| :..:|:.|.||:|||..|....||.|..|:::||||.||.|||:
plant  1016 ------VGET-SEELNNVEGTIELKGVHFSYPSRPDVVIFRDFDLIVRAGKSMALVGQSGSGKSS 1073

  Fly  1103 CVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSM 1167
            .:.|:.|:|||..|.:.|:..||: .|.|..:|..:|:|.|||.||..:|.|||.||:...|.|
plant  1074 VISLILRFYDPTAGKVMIEGKDIK-KLDLKALRKHIGLVQQEPALFATTIYENILYGNEGASQS- 1136

  Fly  1168 VEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALD 1232
             |::.:|..|||||||.|||.||.|::|.||.|:||||:||||||||:::||.||||||||||||
plant  1137 -EVVESAMLANAHSFITSLPEGYSTKVGERGVQMSGGQRQRIAIARAILKNPAILLLDEATSALD 1200

  Fly  1233 LQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLI-SQGGIYAKLH 1296
            ::||::||||||...:.||.:|:||||||::|||.|.|:..|::||||:|.:|: ::.|.|.||.
plant  1201 VESERVVQQALDRLMANRTTVVVAHRLSTIKNADTISVLHGGKIVEQGSHRKLVLNKSGPYFKLI 1265

  Fly  1297 KTQK 1300
            ..|:
plant  1266 SLQQ 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	441/1225 (36%)
		ABC_membrane	108..354	CDD:279056	69/246 (28%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	132/237 (56%)
		ABC_membrane	736..1006	CDD:279056	73/273 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	126/240 (53%)
ABCB2	NP_194326.2	PTZ00265	76..1269	CDD:240339	446/1269 (35%)
		ABC_membrane	86..349	CDD:279056	73/295 (25%)
		ABC_MTABC3_MDL1_MDL2	401..639	CDD:213216	132/252 (52%)
		ABC_membrane	714..983	CDD:279056	73/273 (27%)
		ABC_MTABC3_MDL1_MDL2	1030..1268	CDD:213216	126/240 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790