DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB9

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001328203.1	Gene:	ABCB9 / 827530	AraportID:	AT4G18050	Length:	1246	Species:	Arabidopsis thaliana

Alignment Length:	1318	Identity:	482/1318 - (36%)
Similarity:	727/1318 - (55%)	Gaps:	117/1318 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVII 68
            :|.|:..::|.:|:             ::|.|||.|:...::..:..|.|......||.|.:.:|
plant    12 EEKSSKKNDGGNQK-------------VSFFKLFSFADKTDVVLMTVGTIAAAGNGLTQPFMTLI 63

  Fly    69 YSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFI 133
            :.:..:       .|||:...|.:             ||     ::..::.:..|...:.||.|:
plant    64 FGQLIN-------AFGTTDPDHMV-------------RE-----VWKVAVKFIYLAVYSCVVAFL 103

  Fly   134 SGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQ-NFTQSMVDDVEKIRDGISEKVG 197
                .|..:.:...||...:|.....:::|||||:.|..:.. .....|..|...|:|.:.||||
plant   104 ----QVSCWMVTGERQSATIRGLYLKTILRQDIGYFDTETNTGEVIGRMSGDTILIQDAMGEKVG 164

  Fly   198 HFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEE 262
            .|..|:..|:...||:|..|..|...:.|.|||:::....::....|:..|.|.:||.|||:.|:
plant   165 KFTQLLCTFLGGFAIAFYKGPLLAGVLCSCIPLIVIAGAAMSLIMSKMAGRGQVAYAEAGNVVEQ 229

  Fly   263 ILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLI 327
            .:.:|||||:|.|||...::||:.|..|.|....:|..||.....:.::::.|...|.|||..||
plant   230 TVGAIRTVVAFTGEKQATEKYESKLEIAYKTVVQQGLISGFGLGTMLAVIFCSYGLAVWYGAKLI 294

  Fly   328 IDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLST 392
            ::      |.|....::...|.::.|..::.:|:|.|.:||..|..|..:|:.|..:.|||....
plant   295 ME------KGYNGGQVINVIFAVLTGGMSLGQTSPSLNAFAAGRAAAFKMFETIKRSPKIDAYDM 353

  Fly   393 DGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFY 457
            .|.:|. .:|||:|.:||:||||:||:|.:..|.::.:..|:||||||.||.||||.:.|::|||
plant   354 SGSVLE-DIRGDIELKDVYFRYPARPDVQIFAGFSLFVPNGKTVALVGQSGSGKSTVISLIERFY 417

  Fly   458 DPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGA 522
            ||..|.||:|::|::|..::|:||.|.:|.||||||..||.:||:|||..||.:||..|...|.|
plant   418 DPESGQVLIDNIDLKKLQLKWIRSKIGLVSQEPVLFATTIKENIAYGKEDATDQEIRTAIELANA 482

  Fly   523 HEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALD 587
            .:||..||:...:|:||.|:|:|||||||:|||||:::|||||||||||||||.:||:.||.||.
plant   483 AKFIDKLPQGLDTMVGEHGTQMSGGQKQRLAIARAILKNPKILLLDEATSALDAESERIVQDALV 547

  Fly   588 LASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDEVE 651
            .....|||:||:|||:.||.||.|..:|.||::|:|:||:::. .||||..:||.      .|..
plant   548 NLMSNRTTVVVAHRLTTIRTADVIAVVHQGKIVEKGTHDEMIQDPEGAYSQLVRL------QEGS 606

  Fly   652 KEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIK--------ALIKDTNAQSAEAP 708
            ||::.|..:.::....|:|   ..|......:.||.......:        ......|....:..
plant   607 KEEATESERPETSLDVERS---GSLRLSSAMRRSVSRNSSSSRHSFSLASNMFFPGVNVNQTDEM 668

  Fly   709 PEKPNFFR----TFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGE----FY--AALAEK 763
            .::.|..|    :..|:..|.|.|...|:||:|:|:..|.::|.|.::...    ||  |.:.:|
plant   669 EDEENNVRHKKVSLKRLAHLNKPEIPVLVLGSIAAMVHGTVFPIFGLLLSSSINMFYEPAKILKK 733

  Fly   764 DPEDALRRTAVLSWACLGLAF-LTGLVCF-LQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDD 826
            |..         .||.:.:|. ||..|.. :|.|.|..||..|..|:|:|.|:.:|:||:.||||
plant   734 DSH---------FWALIYIALGLTNFVMIPVQNYFFGIAGGKLIKRIRSMCFDKVVHQEISWFDD 789

  Fly   827 ENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGS 891
            ..||               :..:|..|:.::|.::...:.:.:|...||.|||:.||..|.||..
plant   790 TANS---------------RSLVGDALALIVQNIATVTTGLIIAFTANWILALIVLALSPFIVIQ 839

  Fly   892 VILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLR 956
            ...:.|.::......|.:.|||.::|.:::::|||||....|..|:..|.   |:.:...:..:|
plant   840 GYAQTKFLTGFSADAKAMYEEASQVANDAVSSIRTVASFCAEEKVMDLYQ---QKCDGPKKNGVR 901

  Fly   957 WRGVLNSTMQASAFFAYAV-ALCY--GGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAF 1018
            ...:..:....|.||.|.: .:|:  |..|:..|:..|.::.||...|...::.::|:.|..|..
plant   902 LGLLSGAGFGFSFFFLYCINCVCFVSGAGLIQIGKATFGEVFKVFFALTIMAIGVSQTSAMAPDS 966

  Fly  1019 SAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLE 1083
            :.|..:...:|.|||..|||.|  .:.:.|..:.:|  ..:.:|.:.||||.|||.:|...|.|.
plant   967 NKAKDSAASIFDILDSTPKIDS--SSDEGTTLQNVN--GDIEFRHVSFRYPMRPDVQIFRDLCLT 1027

  Fly  1084 VLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLF 1148
            :..|:||||||.||.||||.:.:::|:|:||.|.|.||..:|| ...|..:|.::|:|||||.||
plant  1028 IPSGKTVALVGESGSGKSTVISMIERFYNPDSGKILIDQVEIQ-TFKLSWLRQQMGLVSQEPILF 1091

  Fly  1149 ERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
            ..:|..||||| .....:..|||||||:||||:||.|||.||||.:|.||.||||||||||||||
plant  1092 NETIRSNIAYG-KTGGATEEEIIAAAKAANAHNFISSLPQGYDTSVGERGVQLSGGQKQRIAIAR 1155

  Fly  1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVE 1278
            |::::||||||||||||||.:||::||.|||.....||.:|:||||:|::|||||.|::||.:.|
plant  1156 AILKDPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLTTIKNADVIAVVKNGVIAE 1220

  Fly  1279 QGNHMQLIS-QGGIYAKL 1295
            :|.|..|:. .||.||.|
plant  1221 KGRHETLMKISGGAYASL 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	463/1231 (38%)
		ABC_membrane	108..354	CDD:279056	70/246 (28%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	129/237 (54%)
		ABC_membrane	736..1006	CDD:279056	77/280 (28%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	134/238 (56%)
ABCB9	NP_001328203.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790