DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB5

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_192092.1	Gene:	ABCB5 / 826974	AraportID:	AT4G01830	Length:	1230	Species:	Arabidopsis thaliana

Alignment Length:	1282	Identity:	477/1282 - (37%)
Similarity:	721/1282 - (56%)	Gaps:	84/1282 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHAL 92
            |:.:.|.|||.||...::..:..|.|......:..|.:.:::.|    |:| ||
plant    10 TKTVPFYKLFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGE----LID-AM----------- 58

  Fly    93 PLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKL 157
                        ...:|||.:.:......:.|....:....:....|..:.:...||..|:|...
plant    59 ------------GPNQNNEEIVERVSKVCLSLVYLGLGALGAAFLQVACWMITGERQAARIRSLY 111

  Fly   158 FSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLT 221
            ..:::|||||:.|: .:.......|..|...|.|.:.||||.|:.|:..|:....|:|..||.||
plant   112 LKTILRQDIGFFDVEMTTGEVVGRMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWLLT 176

  Fly   222 LAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENF 286
            |.:.:.|||:.:....:|....:.:::||.:||.|.|:.|:.|.|||||.||.|||..:..|:..
plant   177 LVMLTSIPLLAMSGAAIAIIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQAMSSYKEL 241

  Fly   287 LVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGII 351
            :..|.|::..:|..:||...|:..:.:.:.|...|:|..:|:      .|.||...::.....::
plant   242 INLAYKSNVKQGFVTGLGLGVMFLVFFSTYALGTWFGGEMIL------RKGYTGGAVINVMVTVV 300

  Fly   352 VGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPS 416
            ..:..:.:.:|.|.:|...:..|..:|:.|:....||....:||:|. .:||::|.:||.|.||:
plant   301 SSSIALGQASPCLTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLE-DIRGEIELRDVCFSYPA 364

  Fly   417 RPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRS 481
            ||:..|..|.::.|.:|.|.||||.||.||||.:.|::|||||..|.||:|.:|::::.::|:|.
plant   365 RPKEEVFGGFSLLIPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLIDGVDLKEFQLKWIRG 429

  Fly   482 NIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSG 546
            .|.:|.||||||..:|.:||.|||.|||.:||:||:..|.|.:||..||....:::||.|:||||
plant   430 KIGLVSQEPVLFSSSIMENIGYGKEGATVEEIQAASKLANAAKFIDKLPLGLETLVGEHGTQLSG 494

  Fly   547 GQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKI 611
            |||||||||||::::|:||||||||||||.:||:.||:|||.....|||::|:||||.:|.||.|
plant   495 GQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVIVAHRLSTVRNADII 559

  Fly   612 VFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSP 675
            ..||.||::|||||.:|:. .||||..::|..:||      ||       .|.|.:.:.|..:..
plant   560 AVIHRGKIVEEGSHSELLKDHEGAYSQLLRLQEIN------KE-------SKRLEISDGSISSGS 611

  Fly   676 LNFEKGQKNSVQFEEPI-IKALI--KDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTI 737
               .:|..::.|.::.. :..|:  :|:...|.|...:.     :|:||..|.|.|...|||||:
plant   612 ---SRGNNSTRQDDDSFSVLGLLAGQDSTKMSQELSQKV-----SFTRIAALNKPEIPILILGTL 668

  Fly   738 SAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLS--WACLGLAFLTGLVCFLQTYLFNYA 800
            .....|.::|.|.::|.:...|.. |.|.:..|.:...|  :..||:|.:  :|.....|||..|
plant   669 VGAVNGTIFPIFGILFAKVIEAFF-KAPHELKRDSRFWSMIFVLLGVAAV--IVYPTTNYLFAIA 730

  Fly   801 GIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFIS 865
            |..|..|:|:|.|..:|:.||||||:..||.||:.||||.:|..|:..:|..|...::.:::.::
plant   731 GGRLIRRIRSMCFEKVVHMEVGWFDEPGNSSGAMGARLSADAALIRTLVGDSLCLSVKNVASLVT 795

  Fly   866 SVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGL 930
            .:.:|...:|::|::.|...|.|..:..::.|.|.......|...|||.::|.:::.:|||||..
plant   796 GLIIAFTASWEVAIIILVIIPFIGINGYIQIKFMKGFSADAKAKYEEASQVANDAVGSIRTVASF 860

  Fly   931 RREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFA-YAV-ALCY--GGVLVSEGQLPF 991
            ..|..|:..|.   :|.|..|:..:: :|:::......:||. |:| |.|:  |..||..|:..|
plant   861 CAEEKVMEMYK---KRCEDTIKSGIK-QGLISGVGFGISFFVLYSVYASCFYVGARLVKAGRTNF 921

  Fly   992 QDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQS--PMGTIKNTLAKQLN 1054
            .|:.:|...|...::.::|:.:|.|..|....|...:|:|:||..||.|  ..|.:...:...:.
plant   922 NDVFQVFLALTLTAVGISQASSFAPDSSKGKGAAVSIFRIIDRISKIDSRDESGMVLENVKGDIE 986

  Fly  1055 LFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIH 1119
            |..      |.|.|.||||.::...|.|.:..||||||||.||.||||.:.||||:||||.|.|.
plant   987 LCH------ISFTYQTRPDVQVFRDLCLSIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHIT 1045

  Fly  1120 IDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFII 1184
            :|..::: .|.|..:|.::|:|.|||.||..:|..|||||......:..|||||::.||||.||.
plant  1046 LDGVELK-KLRLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGGEEATEAEIIAASELANAHRFIS 1109

  Fly  1185 SLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSG 1249
            |:..||||.:|.||.|||||||||:|||||:|:.||||||||||||||.:||::||.|||.....
plant  1110 SIQKGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVN 1174

  Fly  1250 RTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYAKL 1295
            ||.||:||||||::|||||.|::||.:.|:|.|..||: :||:||.|
plant  1175 RTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLINIEGGVYASL 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	462/1219 (38%)
		ABC_membrane	108..354	CDD:279056	69/246 (28%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	128/237 (54%)
		ABC_membrane	736..1006	CDD:279056	82/275 (30%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	133/238 (56%)
ABCB5	NP_192092.1	PTZ00265	2..1224	CDD:240339	477/1282 (37%)
		ABC_membrane	35..293	CDD:279056	76/291 (26%)
		ABC_MTABC3_MDL1_MDL2	353..591	CDD:213216	128/237 (54%)
		ABC_membrane	667..936	CDD:279056	82/275 (30%)
		ABC_MTABC3_MDL1_MDL2	985..1224	CDD:213216	134/244 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790