DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB3

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_192091.1	Gene:	ABCB3 / 826951	AraportID:	AT4G01820	Length:	1229	Species:	Arabidopsis thaliana

Alignment Length:	1285	Identity:	482/1285 - (37%)
Similarity:	716/1285 - (55%)	Gaps:	82/1285 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVH 90
            |.|:.:.|.|||.||...::..:..|.|......:..|.:.:::.:    |:|...|
plant     3 EKTKTVPFYKLFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGD----LIDSIGQ-------- 55

  Fly    91 ALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRI 155
                        |.|.::..|.:....:.: :.|.:.::.   :....|..:.:...||..|:|.
plant    56 ------------NQSNKDIVEIVSKVCLKF-VYLGLGTLG---AAFLQVACWMITGERQAARIRS 104

  Fly   156 KLFSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWK 219
            ....:::|||||:.|: .|.......|..|...|.:.:.||||.|:.|:..|:....::|..||.
plant   105 LYLKTILRQDIGFFDVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWL 169

  Fly   220 LTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYE 284
            |||.:...|||:.:....:.....:.::|||.:||.|..:.|:.|.|||||.||.|||..::.|.
plant   170 LTLVMLVSIPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYR 234

  Fly   285 NFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFG 349
            .|:..|.:||..:|...||...|:..:.:.|.|.|.|:|..:|:      .|.||...::.....
plant   235 EFINLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMIL------KKGYTGGEVVNVMVT 293

  Fly   350 IIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRY 414
            ::..:.::.:|.|.|.:||..:..|..:|:.|:....||....:||:|. .:||::|.:||.|.|
plant   294 VVASSMSLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLE-DIRGEIELRDVCFSY 357

  Fly   415 PSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWL 479
            |:||...|..|.::.|.:|.|.||||.||.|||:.:.|::|||||..||||:|.::::::.::|:
plant   358 PARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEFQLKWI 422

  Fly   480 RSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQL 544
            |..|.:|.||||||..:|.:||.|||..||.:||:|||..|.|..||..||....:::||.|:||
plant   423 RGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLETLVGEHGTQL 487

  Fly   545 SGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGAD 609
            |||||||||||||::::|:||||||||||||.:||:.||:|||.....|||::|:||||.:|.||
plant   488 SGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRTTVIVAHRLSTVRNAD 552

  Fly   610 KIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINM-PDEVEKEDSIEDTKQKSLALFEKSFE 672
            .|..||.||::|||||.:|:. .||||..::|...|.. |..:|..:.:.|.
plant   553 MIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKIKKEPKRLESSNELRDR------------- 604

  Fly   673 TSPLNFEKGQKNSVQ---FEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLIL 734
                :..:|...:::   .::..:..|......::.|...|:.... :.:||..|.|.|...|||
plant   605 ----SINRGSSRNIRTRVHDDDSVSVLGLLGRQENTEISREQSRNV-SITRIAALNKPETTILIL 664

  Fly   735 GTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLS--WACLGLAFLTGLVCFLQTYLF 797
            ||:.....|.::|.|.::|.:...|.. |.|.|..|.:...|  :..||:|.|  :|..:.||||
plant   665 GTLLGAVNGTIFPIFGILFAKVIEAFF-KPPHDMKRDSRFWSMIFVLLGVASL--IVYPMHTYLF 726

  Fly   798 NYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSN 862
            ..||..|..|:|.|.|..:|:.|||||||..||.|.:.:|||.:|..|:..:|..||..::..:.
plant   727 AVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSRLSADAALIKTLVGDSLSLSVKNAAA 791

  Fly   863 FISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTV 927
            .:|.:.:|...:||||::.|...|:|..:..|:.|.:.......|...|||.::|.:::.:||||
plant   792 AVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIKFIKGFTADAKAKYEEASQVANDAVGSIRTV 856

  Fly   928 AGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFA-YAV-ALCY--GGVLVSEGQ 988
            |....|..|:..|.   :|.|..|:..:: :|:::......:||. |:| |.|:  |..||..|:
plant   857 ASFCAEEKVMEMYK---KRCEDTIKSGIK-QGLISGVGFGISFFVLYSVYASCFYVGARLVKAGR 917

  Fly   989 LPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQS--PMGTIKNTLAK 1051
            ..|.|:.:|...|...::.::|:.:|.|..|.|..|...:|.|:|.|..|.|  ..|.:...:..
plant   918 TNFNDVFQVFLALTMTAIGISQASSFAPDSSKAKGAAASIFGIIDGKSMIDSRDESGLVLENVKG 982

  Fly  1052 QLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEG 1116
            .:.|..      |.|.|.||||.:|...|...:..||||||||.||.||||.:.||||:||||.|
plant   983 DIELCH------ISFTYQTRPDVQIFRDLCFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSG 1041

  Fly  1117 TIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHS 1181
            .|.:|..::: .|.|..||.::|:|.|||.||..:|..|||||......|..||||||:.||||.
plant  1042 HITLDRVELK-KLQLKWVRQQMGLVGQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHG 1105

  Fly  1182 FIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTA 1246
            ||.|:..||||.:|.||.|||||||||:|||||:|:.||||||||||||||.:||::||.|||..
plant  1106 FISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRV 1170

  Fly  1247 CSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYAKL 1295
            ...||.:|:||||||::|||||.|::||.:||:|.|..||: :||:||.|
plant  1171 MVNRTTVVVAHRLSTIKNADVIAVVKNGVIVEKGTHETLINIEGGVYASL 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	468/1220 (38%)
		ABC_membrane	108..354	CDD:279056	69/246 (28%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	127/237 (54%)
		ABC_membrane	736..1006	CDD:279056	88/275 (32%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	136/238 (57%)
ABCB3	NP_192091.1	PTZ00265	4..1223	CDD:240339	481/1284 (37%)
		ABC_membrane	30..286	CDD:279056	76/289 (26%)
		ABC_MTABC3_MDL1_MDL2	348..586	CDD:213216	127/237 (54%)
		ABC_membrane	666..935	CDD:279056	88/275 (32%)
		ABC_MTABC3_MDL1_MDL2	984..1223	CDD:213216	137/244 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790