Protein Alignment Mdr65 and ABCB3

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_192091.1
• Gene: ABCB3 / 826951
• AraportID: AT4G01820
• Length: 1229
• Species: Arabidopsis thaliana
• Alignment Length: 1285
• Identity: 482/1285 - (37%)
• Similarity: 716/1285 - (55%)
• Gaps: 82/1285 - (6%)

  Fly    26 EPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVH 90
            |.|:.:.|.|||.||...::..:..|.|......:..|.:.:::.:    |:|...|
plant     3 EKTKTVPFYKLFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGD----LIDSIGQ-------- 55

  Fly    91 ALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRI 155
                        |.|.::..|.:....:.: :.|.:.::.   :....|..:.:...||..|:|.
plant    56 ------------NQSNKDIVEIVSKVCLKF-VYLGLGTLG---AAFLQVACWMITGERQAARIRS 104

  Fly   156 KLFSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWK 219
            ....:::|||||:.|: .|.......|..|...|.:.:.||||.|:.|:..|:....::|..||.
plant   105 LYLKTILRQDIGFFDVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWL 169

  Fly   220 LTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYE 284
            |||.:...|||:.:....:.....:.::|||.:||.|..:.|:.|.|||||.||.|||..::.|.
plant   170 LTLVMLVSIPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYR 234

  Fly   285 NFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFG 349
            .|:..|.:||..:|...||...|:..:.:.|.|.|.|:|..:|:      .|.||...::.....
plant   235 EFINLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMIL------KKGYTGGEVVNVMVT 293

  Fly   350 IIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRY 414
            ::..:.::.:|.|.|.:||..:..|..:|:.|:....||....:||:|. .:||::|.:||.|.|
plant   294 VVASSMSLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLE-DIRGEIELRDVCFSY 357

  Fly   415 PSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWL 479
            |:||...|..|.::.|.:|.|.||||.||.|||:.:.|::|||||..||||:|.::::::.::|:
plant   358 PARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEFQLKWI 422

  Fly   480 RSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQL 544
            |..|.:|.||||||..:|.:||.|||..||.:||:|||..|.|..||..||....:::||.|:||
plant   423 RGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLETLVGEHGTQL 487

  Fly   545 SGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGAD 609
            |||||||||||||::::|:||||||||||||.:||:.||:|||.....|||::|:||||.:|.||
plant   488 SGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRTTVIVAHRLSTVRNAD 552

  Fly   610 KIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINM-PDEVEKEDSIEDTKQKSLALFEKSFE 672
            .|..||.||::|||||.:|:. .||||..::|...|.. |..:|..:.:.|.
plant   553 MIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKIKKEPKRLESSNELRDR------------- 604

  Fly   673 TSPLNFEKGQKNSVQ---FEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLIL 734
                :..:|...:::   .::..:..|......::.|...|:.... :.:||..|.|.|...|||
plant   605 ----SINRGSSRNIRTRVHDDDSVSVLGLLGRQENTEISREQSRNV-SITRIAALNKPETTILIL 664

  Fly   735 GTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLS--WACLGLAFLTGLVCFLQTYLF 797
            ||:.....|.::|.|.::|.:...|.. |.|.|..|.:...|  :..||:|.|  :|..:.||||
plant   665 GTLLGAVNGTIFPIFGILFAKVIEAFF-KPPHDMKRDSRFWSMIFVLLGVASL--IVYPMHTYLF 726

  Fly   798 NYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSN 862
            ..||..|..|:|.|.|..:|:.|||||||..||.|.:.:|||.:|..|:..:|..||..::..:.
plant   727 AVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSRLSADAALIKTLVGDSLSLSVKNAAA 791

  Fly   863 FISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTV 927
            .:|.:.:|...:||||::.|...|:|..:..|:.|.:.......|...|||.::|.:::.:||||
plant   792 AVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIKFIKGFTADAKAKYEEASQVANDAVGSIRTV 856

  Fly   928 AGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFA-YAV-ALCY--GGVLVSEGQ 988
            |....|..|:..|.   :|.|..|:..:: :|:::......:||. |:| |.|:  |..||..|:
plant   857 ASFCAEEKVMEMYK---KRCEDTIKSGIK-QGLISGVGFGISFFVLYSVYASCFYVGARLVKAGR 917

  Fly   989 LPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQS--PMGTIKNTLAK 1051
            ..|.|:.:|...|...::.::|:.:|.|..|.|..|...:|.|:|.|..|.|  ..|.:...:..
plant   918 TNFNDVFQVFLALTMTAIGISQASSFAPDSSKAKGAAASIFGIIDGKSMIDSRDESGLVLENVKG 982

  Fly  1052 QLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEG 1116
            .:.|..      |.|.|.||||.:|...|...:..||||||||.||.||||.:.||||:||||.|
plant   983 DIELCH------ISFTYQTRPDVQIFRDLCFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSG 1041

  Fly  1117 TIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHS 1181
            .|.:|..::: .|.|..||.::|:|.|||.||..:|..|||||......|..||||||:.||||.
plant  1042 HITLDRVELK-KLQLKWVRQQMGLVGQEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHG 1105

  Fly  1182 FIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTA 1246
            ||.|:..||||.:|.||.|||||||||:|||||:|:.||||||||||||||.:||::||.|||..
plant  1106 FISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRV 1170

  Fly  1247 CSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYAKL 1295
            ...||.:|:||||||::|||||.|::||.:||:|.|..||: :||:||.|
plant  1171 MVNRTTVVVAHRLSTIKNADVIAVVKNGVIVEKGTHETLINIEGGVYASL 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	209/524 (40%)
		MdlB	711..1299	CDD:440747	247/594 (42%)
ABCB3	NP_192091.1	PTZ00265	4..1223	CDD:240339	481/1284 (37%)