Protein Alignment Mdr65 and ABCB21

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_191774.2
• Gene: ABCB21 / 825388
• AraportID: AT3G62150
• Length: 1296
• Species: Arabidopsis thaliana
• Alignment Length: 1318
• Identity: 508/1318 - (38%)
• Similarity: 749/1318 - (56%)
• Gaps: 86/1318 - (6%)

  Fly     2 ERDEVSTSS--SEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPA 64
            :..|:.|.|  .|.|.:.|....|..|.|:.:.|.|||.|:...:|..:..|.|......|..|.
plant    32 DEKELKTESDLKEEKKKTEKNKQEEDEKTKTVPFHKLFAFADSFDIILMILGTIGAVGNGLGFPI 96

  Fly    65 VVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASV 129
            :.|::.:                   .:.:||..:..::.|.:....||   ...|..|.|:.:.
plant    97 MTILFGD-------------------VIDVFGQNQNSSDVSDKIAKVAL---KFVYLGLGTLVAA 139

  Fly   130 VMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQ-NFTQSMVDDVEKIRDGIS 193
            ::.:||      :.:...||..|:|.....:::||||.:.|:.:.. .....|..|...|:|.:.
plant   140 LLQVSG------WMISGERQAGRIRSLYLQTILRQDIAFFDVETNTGEVVGRMSGDTVLIQDAMG 198

  Fly   194 EKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGN 258
            ||||..:.||..||....|:|:.||.|||.:.|.|||:::....:|....|:.:|.|.|||.|..
plant   199 EKVGKAIQLVSTFIGGFVIAFTEGWLLTLVMVSSIPLLVMSGAALAIVISKMASRGQTSYAKAAV 263

  Fly   259 LAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYG 323
            :.|:.:.|||||.||.|||..:..|...||.|.:|..::||.:||....|..:::.:.|.|.|||
plant   264 VVEQTVGSIRTVASFTGEKQAISNYNKHLVSAYRAGVFEGASTGLGLGTLNIVIFCTYALAVWYG 328

  Fly   324 VNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKID 388
            ..:|::      |.||...::|..|.::.|:.::.:.:|.|.:||..:..|..:|:.|....:||
plant   329 GKMILE------KGYTGGQVLIIIFAVLTGSMSLGQASPCLSAFAAGQAAAYKMFEAIKRKPEID 387

  Fly   389 PLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLL 453
            ...|.||:|: .:|||:|..:|.|.||:|||..:.||.::.|.:|.||||||.||.||||.|.|:
plant   388 ASDTTGKVLD-DIRGDIELNNVNFSYPARPEEQIFRGFSLSISSGSTVALVGQSGSGKSTVVSLI 451

  Fly   454 QRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAAT 518
            :|||||..|.|.:|.::::::.::|:||.|.:|.||||||..:|.:||:|||..||.:||..|..
plant   452 ERFYDPQSGEVRIDGINLKEFQLKWIRSKIGLVSQEPVLFTSSIKENIAYGKENATVEEIRKATE 516

  Fly   519 QAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQ 583
            .|.|.:||..||:...:|:||.|:|||||||||||:|||::::|:||||||||||||.:||:.||
plant   517 LANASKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERIVQ 581

  Fly   584 QALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMP 647
            :|||.....|||:||:||||.:|.||.|..||.||::|:|||.:|:. .||||..::|..:
plant   582 EALDRIMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHSELLRDPEGAYSQLIRLQE---- 642

  Fly   648 DEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKP 712
            |..:.|||.::.|....::...|...|.|: ....|.|..|......|.| |||   .||.|||.
plant   643 DTKQTEDSTDEQKLSMESMKRSSLRKSSLS-RSLSKRSSSFSMFGFPAGI-DTN---NEAIPEKD 702

  Fly   713 NFFRT--------FSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDAL 769
            ....|        |.|:..|.|.|...||||:|:||..|.:.|.|.::......|.. |.||...
plant   703 IKVSTPIKEKKVSFFRVAALNKPEIPMLILGSIAAVLNGVILPIFGILISSVIKAFF-KPPEQLK 766

  Fly   770 RRTAVLSWA----CLGLAFLTGLVCF-LQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENN 829
            ..|..  ||    .||:|   .:|.| .||..|:.||..|..|:|:|.|..:|..||||||:..|
plant   767 SDTRF--WAIIFMLLGVA---SMVVFPAQTIFFSIAGCKLVQRIRSMCFEKVVRMEVGWFDETEN 826

  Fly   830 SVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVIL 894
            |.||:.||||.:|..::|.:|..|:..:|.|::..:.:.:|...:|:||.:.||..|:|..:..:
plant   827 SSGAIGARLSADAATVRGLVGDALAQTVQNLASVTAGLVIAFVASWQLAFIVLAMLPLIGLNGYI 891

  Fly   895 EAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRG 959
            ..|.|.......|::.|||.::|.:::.:|||||....|..|::.|.   ::.|..:|..:| :|
plant   892 YMKFMVGFSADAKRMYEEASQVANDAVGSIRTVASFCAEEKVMKMYK---KKCEGPMRTGIR-QG 952

  Fly   960 VLNSTMQASAFF----AYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSA 1020
            :::......:||    :||.:...|..||.:|:..|..:.:|...|...::.::||.:.:|..|.
plant   953 IVSGIGFGVSFFVLFSSYAASFYAGARLVDDGKTTFDSVFRVFFALTMAAVAISQSSSLSPDSSK 1017

  Fly  1021 ALIAGHRLFQILDRKPKI--QSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLE 1083
            |..|...:|.::||:.||  ....|.:.:.:...:.|      |.|.|:||:|||.:|...|.|.
plant  1018 ASNAAASIFAVIDRESKIDPSDESGRVLDNVKGDIEL------RHISFKYPSRPDVQIFQDLCLS 1076

  Fly  1084 VLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLF 1148
            :..|:|:||||.||.||||.:.||||:||||.|.|.:|..:|: .|.|..:|.:.|:|||||.||
plant  1077 IRAGKTIALVGESGSGKSTVIALLQRFYDPDSGQITLDGVEIK-TLQLKWLRQQTGLVSQEPVLF 1140

  Fly  1149 ERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
            ..:|..|||||.. ...:..||::||:.:|||.||..|..||||.:|.||.|||||||||:||||
plant  1141 NETIRANIAYGKG-GDATETEIVSAAELSNAHGFISGLQQGYDTMVGERGVQLSGGQKQRVAIAR 1204

  Fly  1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVE 1278
            |:|::||:|||||||||||.:||::||.|||.....||.:|:||||||::|||||.|::||.:||
plant  1205 AIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLSTIKNADVIAVVKNGVIVE 1269

  Fly  1279 QGNHMQLIS-QGGIYAKL 1295
            :|.|..||: :.|:||.|
plant  1270 KGKHETLINIKDGVYASL 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	220/524 (42%)
		MdlB	711..1299	CDD:440747	242/605 (40%)
ABCB21	NP_191774.2	MdlB	79..641	CDD:440747	231/596 (39%)
		MdlB	710..1295	CDD:440747	240/596 (40%)