DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB20

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_191092.1	Gene:	ABCB20 / 824698	AraportID:	AT3G55320	Length:	1408	Species:	Arabidopsis thaliana

Alignment Length:	1405	Identity:	421/1405 - (29%)
Similarity:	695/1405 - (49%)	Gaps:	175/1405 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TSSSEGKSQEEAPMAEGLE-PTEPIAFLKLF----RFSTYGEIGWLFFGFIMCCIKALTLPAVVI 67
            |:::..::.||....:.|| |...:.|.:||    ||.      |:.  .|:..:.|......:|
plant    47 TAAALAEADEEMDDQDELEPPPAAVPFSQLFACADRFD------WVL--MIVGSVAAAAHGTALI 103

  Fly    68 IYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMF 132
            :|..:.:.:|| .:.|                  :|.|.::.:|..:|..:...:.:...:..:|
plant   104 VYLHYFAKIVD-VLAF------------------SNDSSQQRSEHQFDRLVQLSLTIVYIAGGVF 149

  Fly   133 ISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHD-LASKQNFTQSMVDDVEKIRDGISEKV 196
            |||...|..:.:...||...:|.|....::.||:.:.| ..:..:....::.||..|:..:||||
plant   150 ISGWIEVSCWILTGERQTAVIRSKYVQVLLNQDMSFFDTYGNNGDIVSQVLSDVLLIQSALSEKV 214

  Fly   197 GHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAE 261
            |::::.:..||..:.|.|...|::.|...:..|.::........|..:|....|::||.|..:||
plant   215 GNYIHNMATFISGLVIGFVNCWEIALITLATGPFIVAAGGISNIFLHRLAENIQDAYAEAAGIAE 279

  Fly   262 EILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNL 326
            :.:|.|||:.:|..|......|...|....:.........||.......:...|||...|.|...
plant   280 QAISYIRTLYAFTNETLAKYSYATSLQATLRYGILISLVQGLGLGFTYGLAICSCALQLWIGRFF 344

  Fly   327 IIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLS 391
                  |.|.......::.|.|.:|:....:.:.|....||...|..|..||::|..:|.:  .:
plant   345 ------VHNGRANGGEIIAALFAVILSGLGLNQAATNFYSFDQGRIAAYRLFEMITRSSSV--AN 401

  Fly   392 TDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRF 456
            .:|.:| ..::|::||::|:|.|.||||:.:..|..:.:.|.:.|||||.:|.|||:.:.|::||
plant   402 QEGAVL-ASVQGNIEFRNVYFSYLSRPEIPILSGFYLTVPAKKAVALVGRNGSGKSSIIPLMERF 465

  Fly   457 YDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAG 521
            |||..|.||||..:|:...::||||.|.:|.|||.|...:|.:||:||: .||..:||.||..|.
plant   466 YDPTLGEVLLDGENIKNLKLEWLRSQIGLVTQEPALLSLSIRENIAYGR-DATLDQIEEAAKNAH 529

  Fly   522 AHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQAL 586
            ||.||::|.:.|.:.:|..|..::..||.:::||||::.||.||||||.|..||:::|:.||:||
plant   530 AHTFISSLEKGYETQVGRAGLAMTEEQKIKLSIARAVLLNPTILLLDEVTGGLDFEAERIVQEAL 594

  Fly   587 DLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDI-----NM 646
            ||...||:||:::.|||.|:.||.|..:.:|:::|.|:||:|:.|.|.|..:::..:.     .|
plant   595 DLLMLGRSTIIIARRLSLIKNADYIAVMEEGQLVEMGTHDELINLGGLYAELLKCEEATKLPRRM 659

  Fly   647 PDEVEKEDSIEDTKQKSLA-----------------------LF---EKSFET-------SPLNF 678
            |....||.::.:.::.|.|                       :|   |..|:|       ||.:.
plant   660 PVRNYKESAVFEVERDSSAGCGVQEPSSPKMIKSPSLQRGSGVFRPQELCFDTEESPKAHSPASE 724

  Fly   679 EKGQ--------------------------------------KNSVQFEEPIIKALIKD-----T 700
            :.|:                                      .|..:.|.|:...|..|     :
plant   725 KTGEDGMSLDCADKEPTIKRQDSFEMRLPHLPKVDVQCPQQKSNGSEPESPVSPLLTSDPKNERS 789

  Fly   701 NAQSAEAPPEKPNFFR---------------TFSRILQLAKQEWCYLILGTISAVAVGFLYP--- 747
            ::|:...|...|:..:               :|.|:.||:..||.|.:||::.|...|...|
plant   790 HSQTFSRPLSSPDDTKANGKASKDAQHKESPSFWRLAQLSFPEWLYAVLGSLGAAIFGSFNPLLA 854

  Fly   748 -AFAVIFGEFYAALAEKDPEDALRRTAVLSW----ACLGLAFLTGLVCFLQTYLFNYAGIWLTTR 807
             ..|::..|:|.:      :....|..|..|    ||:|:  :|.:..|||.:.|...|..:|.|
plant   855 YVIALVVTEYYKS------KGGHLREEVDKWCLIIACMGI--VTVVANFLQHFYFGIMGEKMTER 911

  Fly   808 MRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMY 872
            :|.|.|:||:..||||||||.||...||.||:.:|..::.|....||..||.....|.::.:.:.
plant   912 VRRMMFSAMLRNEVGWFDDEENSPDTLSMRLANDATFVRAAFSNRLSIFIQDSFAVIVALLIGLL 976

  Fly   873 YNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVI 937
            ..|:|||:.||..||:..|.|.:...::......:::..:|..:..:::.||.||........|:
plant   977 LGWRLALVALATLPILTLSAIAQKLWLAGFSKGIQEMHRKASLVLEDAVRNIYTVVAFCAGNKVM 1041

  Fly   938 REYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY---AVALCYGGVLVSEGQLPFQDIIKVSE 999
            ..|..::||:   :||.......:......|.|..:   |:.|....:.|:.|.:.....|....
plant  1042 ELYRMQLQRI---LRQSYLHGMAIGFAFGFSQFLLFACNALLLWCTALSVNRGYMKLSTAITEYM 1103

  Fly  1000 TLLYGSMMLAQSLAFTPAF---SAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRY 1061
            ...:.:..|.:.....|..   ..:||:   :|:|:||.|.|:..    .|:..|..|::..:..
plant  1104 VFSFATFALVEPFGLAPYILKRRKSLIS---VFEIVDRVPTIEPD----DNSALKPPNVYGSIEL 1161

  Fly  1062 RGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQ 1126
            :.:.|.|||||:..:|:...|::..|||||:||.||.||||.:.|::|||||..|.:.:|..|::
plant  1162 KNVDFCYPTRPEILVLSNFSLKISGGQTVAVVGVSGSGKSTIISLVERYYDPVAGQVLLDGRDLK 1226

  Fly  1127 HDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYD 1191
            . ..|..:|:.:|:|.|||.:|..:|.|||.|.  |.:.|..|:..||:.||||.||.|||:|||
plant  1227 L-YNLRWLRSHMGLVQQEPIIFSTTIRENIIYA--RHNASEAEMKEAARIANAHHFISSLPHGYD 1288

  Fly  1192 TRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSG-RTCIVI 1255
            |.:|.||.:|:.||||||||||.:::|..|:|:|||:|:::.:|.::||:||||...| :|.|:|
plant  1289 THIGMRGVELTPGQKQRIAIARVVLKNAPIILIDEASSSIESESSRVVQEALDTLIMGNKTTILI 1353

  Fly  1256 AHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
            |||.:.:::.|.|.|:..|::||:|.|..|.::.|:|.:|
plant  1354 AHRAAMMRHVDNIVVLNGGRIVEEGTHDSLAAKNGLYVRL 1393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	402/1317 (31%)
		ABC_membrane	108..354	CDD:279056	57/246 (23%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	106/236 (45%)
		ABC_membrane	736..1006	CDD:279056	74/280 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	108/238 (45%)
ABCB20	NP_191092.1	MdlB	86..651	CDD:224055	184/595 (31%)
		ABC_membrane	93..366	CDD:279056	65/297 (22%)
		P-loop_NTPase	414..648	CDD:304359	106/234 (45%)
		MdlB	821..1400	CDD:224055	204/594 (34%)
		ABC_membrane	841..1112	CDD:279056	74/281 (26%)
		P-loop_NTPase	1159..1395	CDD:304359	108/238 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780