Protein Alignment Mdr65 and ABCB20

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_191092.1
• Gene: ABCB20 / 824698
• AraportID: AT3G55320
• Length: 1408
• Species: Arabidopsis thaliana
• Alignment Length: 1405
• Identity: 421/1405 - (29%)
• Similarity: 695/1405 - (49%)
• Gaps: 175/1405 - (12%)

  Fly     8 TSSSEGKSQEEAPMAEGLE-PTEPIAFLKLF----RFSTYGEIGWLFFGFIMCCIKALTLPAVVI 67
            |:::..::.||....:.|| |...:.|.:||    ||.      |:.  .|:..:.|......:|
plant    47 TAAALAEADEEMDDQDELEPPPAAVPFSQLFACADRFD------WVL--MIVGSVAAAAHGTALI 103

  Fly    68 IYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMF 132
            :|..:.:.:|| .:.|                  :|.|.::.:|..:|..:...:.:...:..:|
plant   104 VYLHYFAKIVD-VLAF------------------SNDSSQQRSEHQFDRLVQLSLTIVYIAGGVF 149

  Fly   133 ISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHD-LASKQNFTQSMVDDVEKIRDGISEKV 196
            |||...|..:.:...||...:|.|....::.||:.:.| ..:..:....::.||..|:..:||||
plant   150 ISGWIEVSCWILTGERQTAVIRSKYVQVLLNQDMSFFDTYGNNGDIVSQVLSDVLLIQSALSEKV 214

  Fly   197 GHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAE 261
            |::::.:..||..:.|.|...|::.|...:..|.::........|..:|....|::||.|..:||
plant   215 GNYIHNMATFISGLVIGFVNCWEIALITLATGPFIVAAGGISNIFLHRLAENIQDAYAEAAGIAE 279

  Fly   262 EILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNL 326
            :.:|.|||:.:|..|......|...|....:.........||.......:...|||...|.|...
plant   280 QAISYIRTLYAFTNETLAKYSYATSLQATLRYGILISLVQGLGLGFTYGLAICSCALQLWIGRFF 344

  Fly   327 IIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLS 391
                  |.|.......::.|.|.:|:....:.:.|....||...|..|..||::|..:|.:  .:
plant   345 ------VHNGRANGGEIIAALFAVILSGLGLNQAATNFYSFDQGRIAAYRLFEMITRSSSV--AN 401

  Fly   392 TDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRF 456
            .:|.:| ..::|::||::|:|.|.||||:.:..|..:.:.|.:.|||||.:|.|||:.:.|::||
plant   402 QEGAVL-ASVQGNIEFRNVYFSYLSRPEIPILSGFYLTVPAKKAVALVGRNGSGKSSIIPLMERF 465

  Fly   457 YDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAG 521
            |||..|.||||..:|:...::||||.|.:|.|||.|...:|.:||:||: .||..:||.||..|.
plant   466 YDPTLGEVLLDGENIKNLKLEWLRSQIGLVTQEPALLSLSIRENIAYGR-DATLDQIEEAAKNAH 529

  Fly   522 AHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQAL 586
            ||.||::|.:.|.:.:|..|..::..||.:::||||::.||.||||||.|..||:::|:.||:||
plant   530 AHTFISSLEKGYETQVGRAGLAMTEEQKIKLSIARAVLLNPTILLLDEVTGGLDFEAERIVQEAL 594

  Fly   587 DLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDI-----NM 646
            ||...||:||:::.|||.|:.||.|..:.:|:::|.|:||:|:.|.|.|..:::..:.     .|
plant   595 DLLMLGRSTIIIARRLSLIKNADYIAVMEEGQLVEMGTHDELINLGGLYAELLKCEEATKLPRRM 659

  Fly   647 PDEVEKEDSIEDTKQKSLA-----------------------LF---EKSFET-------SPLNF 678
            |....||.::.:.::.|.|                       :|   |..|:|       ||.:.
plant   660 PVRNYKESAVFEVERDSSAGCGVQEPSSPKMIKSPSLQRGSGVFRPQELCFDTEESPKAHSPASE 724

  Fly   679 EKGQ--------------------------------------KNSVQFEEPIIKALIKD-----T 700
            :.|:                                      .|..:.|.|:...|..|     :
plant   725 KTGEDGMSLDCADKEPTIKRQDSFEMRLPHLPKVDVQCPQQKSNGSEPESPVSPLLTSDPKNERS 789

  Fly   701 NAQSAEAPPEKPNFFR---------------TFSRILQLAKQEWCYLILGTISAVAVGFLYP--- 747
            ::|:...|...|:..:               :|.|:.||:..||.|.:||::.|...|...|
plant   790 HSQTFSRPLSSPDDTKANGKASKDAQHKESPSFWRLAQLSFPEWLYAVLGSLGAAIFGSFNPLLA 854

  Fly   748 -AFAVIFGEFYAALAEKDPEDALRRTAVLSW----ACLGLAFLTGLVCFLQTYLFNYAGIWLTTR 807
             ..|::..|:|.:      :....|..|..|    ||:|:  :|.:..|||.:.|...|..:|.|
plant   855 YVIALVVTEYYKS------KGGHLREEVDKWCLIIACMGI--VTVVANFLQHFYFGIMGEKMTER 911

  Fly   808 MRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMY 872
            :|.|.|:||:..||||||||.||...||.||:.:|..::.|....||..||.....|.::.:.:.
plant   912 VRRMMFSAMLRNEVGWFDDEENSPDTLSMRLANDATFVRAAFSNRLSIFIQDSFAVIVALLIGLL 976

  Fly   873 YNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVI 937
            ..|:|||:.||..||:..|.|.:...::......:::..:|..:..:::.||.||........|:
plant   977 LGWRLALVALATLPILTLSAIAQKLWLAGFSKGIQEMHRKASLVLEDAVRNIYTVVAFCAGNKVM 1041

  Fly   938 REYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAY---AVALCYGGVLVSEGQLPFQDIIKVSE 999
            ..|..::||:   :||.......:......|.|..:   |:.|....:.|:.|.:.....|....
plant  1042 ELYRMQLQRI---LRQSYLHGMAIGFAFGFSQFLLFACNALLLWCTALSVNRGYMKLSTAITEYM 1103

  Fly  1000 TLLYGSMMLAQSLAFTPAF---SAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRY 1061
            ...:.:..|.:.....|..   ..:||:   :|:|:||.|.|:..    .|:..|..|::..:..
plant  1104 VFSFATFALVEPFGLAPYILKRRKSLIS---VFEIVDRVPTIEPD----DNSALKPPNVYGSIEL 1161

  Fly  1062 RGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQ 1126
            :.:.|.|||||:..:|:...|::..|||||:||.||.||||.:.|::|||||..|.:.:|..|::
plant  1162 KNVDFCYPTRPEILVLSNFSLKISGGQTVAVVGVSGSGKSTIISLVERYYDPVAGQVLLDGRDLK 1226

  Fly  1127 HDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYD 1191
            . ..|..:|:.:|:|.|||.:|..:|.|||.|.  |.:.|..|:..||:.||||.||.|||:|||
plant  1227 L-YNLRWLRSHMGLVQQEPIIFSTTIRENIIYA--RHNASEAEMKEAARIANAHHFISSLPHGYD 1288

  Fly  1192 TRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSG-RTCIVI 1255
            |.:|.||.:|:.||||||||||.:::|..|:|:|||:|:::.:|.::||:||||...| :|.|:|
plant  1289 THIGMRGVELTPGQKQRIAIARVVLKNAPIILIDEASSSIESESSRVVQEALDTLIMGNKTTILI 1353

  Fly  1256 AHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
            |||.:.:::.|.|.|:..|::||:|.|..|.::.|:|.:|
plant  1354 AHRAAMMRHVDNIVVLNGGRIVEEGTHDSLAAKNGLYVRL 1393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	173/523 (33%)
		MdlB	711..1299	CDD:440747	205/615 (33%)
ABCB20	NP_191092.1	MdlB	85..646	CDD:440747	185/591 (31%)
		MdlB	821..1393	CDD:440747	203/592 (34%)