DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB22

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001327523.1	Gene:	ABCB22 / 822471	AraportID:	AT3G28415	Length:	1229	Species:	Arabidopsis thaliana

Alignment Length:	1280	Identity:	445/1280 - (34%)
Similarity:	700/1280 - (54%)	Gaps:	100/1280 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASRE 107
            |.||.:..|||        .|.:..|    |.:|::   ..|.||        .|.||..:|..:
plant    25 GLIGAVGDGFI--------TPIIFFI----TGLLLN---DIGDSS--------FGDKTFMHAIMK 66

  Fly   108 ENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDL- 171
            .....||....|.        |:.|:.|.    .:.....||.:|||.|...:|:|||:|:.||
plant    67 NAVALLYVAGASL--------VICFVEGY----CWTRTGERQASRMREKYLRAVLRQDVGYFDLH 119

  Fly   172 -ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLN 235
             .|..:...|:..|...|:|.:|||:.:|:.....|:.:..:.|...|:||:....:..|:::..
plant   120 VTSTSDVITSVSSDTLVIQDVLSEKLPNFLMSASAFVASYIVGFIMLWRLTIVGFPFFILLLIPG 184

  Fly   236 YYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAF 300
            ....:....::.:.:|.|..||::||:.:|.:|||.:||.|:..:.::...|..:.|....:|..
plant   185 LMCGRALINISRKIREEYNEAGSIAEQAISLVRTVYAFGSERKMISKFSAALEGSVKLGLRQGIA 249

  Fly   301 SGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPA---ILMIAFFGIIVGADNIARTAP 362
            .|::.. ...:.|.......|||..:::         |..|   .:......|..|..::.|...
plant   250 KGIAIG-SNGVTYAIWGFMTWYGSRMVM---------YHGAKGGTIFAVIICITYGGTSLGRGLS 304

  Fly   363 FLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLN 427
            .|:.|:.|......:.:||.....||..:..|::|. .::|:|:|:.|.|.|.||||..:...|.
plant   305 NLKYFSEAVVAGERIIEVIKRVPDIDSDNPRGQVLE-NIKGEVQFKHVKFMYSSRPETPIFDDLC 368

  Fly   428 IRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVL 492
            :||.:|::|||||.||.||||.:.||||||||:.|.:|:|.:.|:|..::||||.:.:|.|||.|
plant   369 LRIPSGKSVALVGGSGSGKSTVISLLQRFYDPIVGEILIDGVSIKKLQVKWLRSQMGLVSQEPAL 433

  Fly   493 FLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARA 557
            |..:|.:||.:||..|:..|:..||..:.||:||:..|..|::.:||||.|:||||||||:||||
plant   434 FATSIEENILFGKEDASFDEVVEAAKSSNAHDFISQFPLGYKTQVGERGVQMSGGQKQRISIARA 498

  Fly   558 LIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEE 622
            :|::|.:|||||||||||.:||:.||:|||.|:.||||||::||||.||..|.|....:|:::|.
plant   499 IIKSPTLLLLDEATSALDSESERVVQEALDNATIGRTTIVIAHRLSTIRNVDVICVFKNGQIVET 563

  Fly   623 GSHDDLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKN-- 684
            |||::||. ::|.|.::||   :.:.:..|..|::      |:::.|..|.    ||.|..|.
plant   564 GSHEELMENVDGQYTSLVR---LQIMENEESNDNV------SVSMREGQFS----NFNKDVKYSS 615

  Fly   685 --SVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYP 747
              |:|....:......|||...:....:||    :|.|::.:.|.||.:.:.|.:|||..|.|:|
plant   616 RLSIQSRSSLFATSSIDTNLAGSIPKDKKP----SFKRLMAMNKPEWKHALYGCLSAVLYGALHP 676

  Fly   748 AFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMT 812
            .:|...|...:.......::...:|.:.....:|||.|..|:..:|.|.|.|.|.:||.|:|...
plant   677 IYAYASGSMVSVYFLTSHDEMKEKTRIYVLLFVGLAVLCFLISIIQQYSFAYMGEYLTKRIRENI 741

  Fly   813 FNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVA----MYY 873
            .:.::..||.|||::.||.|::.:||:.:|..::..:|..:|.::|.    ||:||||    :..
plant   742 LSKLLTFEVSWFDEDENSSGSICSRLAKDANVVRSLVGERVSLLVQT----ISAVSVACTLGLAI 802

  Fly   874 NWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGL---RREAD 935
            :|||:::.:|..|::||....:..::.:...:..:..:|:.::|.|:::||||:...   .|...
plant   803 SWKLSIVMIAIQPVVVGCFYTQRIVLKSISKKAIKAQDESSKLAAEAVSNIRTITAFSSQERILK 867

  Fly   936 VIREYTEEIQRVEVLIRQKLRW-RGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSE 999
            :::...|..||..  |||.  | .|::.:|.::......|:...||..|:.:|::..:...::..
plant   868 LLKMVQEGPQREN--IRQS--WLAGIVLATSRSLMTCTSALNYWYGARLIIDGKITSKAFFELFI 928

  Fly  1000 TLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI--QSPMGTIKNTLAKQLNLFEGVRYR 1062
            ..:....::|.:.|.|...:....|...:|.:|||...|  :.|.|.:...:..|      :::.
plant   929 LFVSTGRVIADAGAMTMDLAKGSDAVGSVFAVLDRYTNIEPEKPDGFVPQNIKGQ------IKFV 987

  Fly  1063 GIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQH 1127
            .:.|.||||||..|.....:::.:|::.|:||.||.||||.:.|::|:|||.:|.:.||..||:
plant   988 NVDFAYPTRPDVIIFKNFSIDIDEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIR- 1051

  Fly  1128 DLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDT 1192
            ...|..:|..:|:|||||.||..:|.|||.||.....:...|||.|||:||||.||::|.:||||
plant  1052 SYHLRSLRQHIGLVSQEPILFAGTIRENIMYGGASDKIDESEIIEAAKAANAHDFIVTLSDGYDT 1116

  Fly  1193 RMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAH 1257
            ..|.||.|||||||||||||||:::||.:|||||||||||.|||::||.||.....|||.:||||
plant  1117 YCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDNQSERMVQDALGRLMVGRTSVVIAH 1181

  Fly  1258 RLSTVQNADVICVIQNGQVVEQGNHMQLISQG--GIYAKLHKTQK 1300
            ||||:||.|.|.|:..|:|||.|.|..|:::|  |:|..|...|:
plant  1182 RLSTIQNCDTITVLDKGKVVECGTHSSLLAKGPTGVYFSLVSLQR 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	431/1230 (35%)
		ABC_membrane	108..354	CDD:279056	58/250 (23%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	125/237 (53%)
		ABC_membrane	736..1006	CDD:279056	72/277 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	126/241 (52%)
ABCB22	NP_001327523.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	90	1.000	Domainoid score	I2655
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.790