DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB18

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_189480.1	Gene:	ABCB18 / 822468	AraportID:	AT3G28390	Length:	1225	Species:	Arabidopsis thaliana

Alignment Length:	1227	Identity:	443/1227 - (36%)
Similarity:	696/1227 - (56%)	Gaps:	75/1227 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KTLTNASREENNEALYDDSISYG----ILLTIAS-VVMFISGIFSVDVFNMVALRQVTRMRIKLF 158
            |.|.|......::..:..:::..    :.:..|| |:.||.|.    .:.....||..:||.|..
plant    46 KLLNNVGGSSFDDETFMQTVAKNAVALVYVACASWVICFIEGY----CWTRTGERQAAKMREKYL 106

  Fly   159 SSVIRQDIGWHDL--ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLT 221
            .:|:|||:|:.||  .|..:...|:..|...|:|.:|||:.:|:.....|:.:..:.|...|:||
plant   107 KAVLRQDVGYFDLHVTSTSDVITSVSSDSLVIQDFLSEKLPNFLMNTSAFVASYIVGFLLLWRLT 171

  Fly   222 LAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENF 286
            :....:|.|:::......:...:::.:.:|.|..||::||:::||:|||.:||.||..::::...
plant   172 IVGFPFIILLLIPGLMYGRALIRISMKIREEYNEAGSIAEQVISSVRTVYAFGSEKKMIEKFSTA 236

  Fly   287 LVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGII 351
            |..:.|....:|...|::.. ...:.|.......|||..::: :...:....:..|:.:.|.|..
plant   237 LQGSVKLGLRQGLAKGIAIG-SNGITYAIWGFLTWYGSRMVM-NHGSKGGTVSSVIVCVTFGGTS 299

  Fly   352 VGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPS 416
            :| .:::....|.|:|....    .:.|||:....||..:.:|::|. ..||:|||..|.|.|||
plant   300 LG-QSLSNLKYFSEAFVVGE----RIMKVINRVPGIDSDNLEGQILE-KTRGEVEFNHVKFTYPS 358

  Fly   417 RPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRS 481
            |||..:...|.:|:.:|:||||||.||.||||.:.||||||||:.|.:|:|.|.|.|..::||||
plant   359 RPETPIFDDLCLRVPSGKTVALVGGSGSGKSTVISLLQRFYDPIAGEILIDGLPINKLQVKWLRS 423

  Fly   482 NIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSG 546
            .:.:|.||||||..:|.:||.:||..|:..|:..||..:.||.||:..|.||::.:||||.||||
plant   424 QMGLVSQEPVLFATSIKENILFGKEDASMDEVVEAAKASNAHSFISQFPNSYQTQVGERGVQLSG 488

  Fly   547 GQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKI 611
            |||||||||||:|::|.||||||||||||.:||:.||:|||.||.||||||::||||.||.||.|
plant   489 GQKQRIAIARAIIKSPIILLLDEATSALDSESERVVQEALDNASIGRTTIVIAHRLSTIRNADVI 553

  Fly   612 VFIHDGKVLEEGSHDDLM-ALEGAYYNMVRAGDINMPDEVEKED-SIEDTKQKSLALFEKSFETS 674
            ..:|:|:::|.|||::|: .|:|.|.::||   :...|..|.:. |:|:.:..||:   |..:.|
plant   554 CVVHNGRIIETGSHEELLEKLDGQYTSLVR---LQQVDNKESDHISVEEGQASSLS---KDLKYS 612

  Fly   675 PLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISA 739
            |..|.....:::..:.|.:             :|.:..:...:|.|::.:.:.||.:.:.|.:.|
plant   613 PKEFIHSTSSNIVRDFPNL-------------SPKDGKSLVPSFKRLMSMNRPEWKHALYGCLGA 664

  Fly   740 VAVGFLYPAFAVIFGEFYAA--LAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGI 802
            ...|.:.|.::...|...:.  ||..|......|..||.:  :|||..|.|....|.|.|.|.|.
plant   665 ALFGAVQPIYSYSSGSMVSVYFLASHDQIKEKTRIYVLLF--VGLALFTFLSNISQHYGFAYMGE 727

  Fly   803 WLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSV 867
            :||.|:|......::..||.|||.:.||.||:.:||:.:|..::..:|..:|.::|.:|....:.
plant   728 YLTKRIRERMLGKILTFEVNWFDKDENSSGAICSRLAKDANMVRSLVGDRMSLLVQTISAVSITC 792

  Fly   868 SVAMYYNWKLALLCLANCPIIV-----GSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTV 927
            ::.:..:|:.:::.::..|:||     ..|:|:: |..||:..:    :|:.::|.|:::||||:
plant   793 AIGLVISWRFSIVMMSVQPVIVVCFYTQRVLLKS-MSRNAIKGQ----DESSKLAAEAVSNIRTI 852

  Fly   928 AGLRREADVIR--EYTEEIQRVEVLIRQKLRW-RGVLNSTMQASAFFAYAVALCYGGVLVSEGQL 989
            .....:..:|.  :..:|..|.: ..||.  | .|::..|.|:......|:...|||.|:::|::
plant   853 TAFSSQERIINLLKMVQEGPRKD-SARQS--WLAGIMLGTSQSLITCVSALNFWYGGKLIADGKM 914

  Fly   990 PFQDIIKVSETLLYGS--MMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI--QSPMGTIKNTLA 1050
            ..::.:::  .|::.|  .::|::...|........|...:|.:|||...|  ::|.|.:...:.
plant   915 MSKEFLEI--FLIFASTGRVIAEAGTMTKDLVKGSDAVASVFAVLDRNTTIEPENPDGYVPKKVK 977

  Fly  1051 KQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDE 1115
            .|::      :..:.|.||||||..|.....:::..|::.|:||.||.||||.:.|::|:|||.:
plant   978 GQIS------FSNVDFAYPTRPDVIIFQNFSIDIEDGKSTAIVGPSGSGKSTIISLIERFYDPLK 1036

  Fly  1116 GTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAH 1180
            |.:.||..||: ...|..:|..:.:||||||||..:|.|||.||.....:...|||.|||:||||
plant  1037 GIVKIDGRDIR-SCHLRSLRQHIALVSQEPTLFAGTIRENIMYGGASNKIDESEIIEAAKAANAH 1100

  Fly  1181 SFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDT 1245
            .||.||.|||||..|.||.|||||||||||||||:::||.:|||||||||||.|||.:||.||:.
plant  1101 DFITSLSNGYDTCCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSQSESVVQDALER 1165

  Fly  1246 ACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG--GIYAKLHKTQK 1300
            ...|||.:||||||||:|..|.|.|::||.|||.|||..|:::|  |.|..|...|:
plant  1166 LMVGRTSVVIAHRLSTIQKCDTIAVLENGAVVECGNHSSLLAKGPKGAYFSLVSLQR 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	442/1225 (36%)
		ABC_membrane	108..354	CDD:279056	60/252 (24%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	136/237 (57%)
		ABC_membrane	736..1006	CDD:279056	73/281 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	129/241 (54%)
ABCB18	NP_189480.1	PTZ00265	22..1222	CDD:240339	442/1225 (36%)
		ABC_membrane	27..295	CDD:279056	61/254 (24%)
		ABC_MTABC3_MDL1_MDL2	347..585	CDD:213216	136/240 (57%)
		ABC_membrane	661..927	CDD:279056	72/277 (26%)
		ABC_MTABC3_MDL1_MDL2	980..1221	CDD:213216	129/247 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	90	1.000	Domainoid score	I2655
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.790