Protein Alignment Mdr65 and ABCB18

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_189480.1
• Gene: ABCB18 / 822468
• AraportID: AT3G28390
• Length: 1225
• Species: Arabidopsis thaliana
• Alignment Length: 1227
• Identity: 443/1227 - (36%)
• Similarity: 696/1227 - (56%)
• Gaps: 75/1227 - (6%)

  Fly    99 KTLTNASREENNEALYDDSISYG----ILLTIAS-VVMFISGIFSVDVFNMVALRQVTRMRIKLF 158
            |.|.|......::..:..:::..    :.:..|| |:.||.|.    .:.....||..:||.|..
plant    46 KLLNNVGGSSFDDETFMQTVAKNAVALVYVACASWVICFIEGY----CWTRTGERQAAKMREKYL 106

  Fly   159 SSVIRQDIGWHDL--ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLT 221
            .:|:|||:|:.||  .|..:...|:..|...|:|.:|||:.:|:.....|:.:..:.|...|:||
plant   107 KAVLRQDVGYFDLHVTSTSDVITSVSSDSLVIQDFLSEKLPNFLMNTSAFVASYIVGFLLLWRLT 171

  Fly   222 LAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENF 286
            :....:|.|:::......:...:::.:.:|.|..||::||:::||:|||.:||.||..::::...
plant   172 IVGFPFIILLLIPGLMYGRALIRISMKIREEYNEAGSIAEQVISSVRTVYAFGSEKKMIEKFSTA 236

  Fly   287 LVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGII 351
            |..:.|....:|...|::.. ...:.|.......|||..::: :...:....:..|:.:.|.|..
plant   237 LQGSVKLGLRQGLAKGIAIG-SNGITYAIWGFLTWYGSRMVM-NHGSKGGTVSSVIVCVTFGGTS 299

  Fly   352 VGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPS 416
            :| .:::....|.|:|....    .:.|||:....||..:.:|::|. ..||:|||..|.|.|||
plant   300 LG-QSLSNLKYFSEAFVVGE----RIMKVINRVPGIDSDNLEGQILE-KTRGEVEFNHVKFTYPS 358

  Fly   417 RPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRS 481
            |||..:...|.:|:.:|:||||||.||.||||.:.||||||||:.|.:|:|.|.|.|..::||||
plant   359 RPETPIFDDLCLRVPSGKTVALVGGSGSGKSTVISLLQRFYDPIAGEILIDGLPINKLQVKWLRS 423

  Fly   482 NIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSG 546
            .:.:|.||||||..:|.:||.:||..|:..|:..||..:.||.||:..|.||::.:||||.||||
plant   424 QMGLVSQEPVLFATSIKENILFGKEDASMDEVVEAAKASNAHSFISQFPNSYQTQVGERGVQLSG 488

  Fly   547 GQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKI 611
            |||||||||||:|::|.||||||||||||.:||:.||:|||.||.||||||::||||.||.||.|
plant   489 GQKQRIAIARAIIKSPIILLLDEATSALDSESERVVQEALDNASIGRTTIVIAHRLSTIRNADVI 553

  Fly   612 VFIHDGKVLEEGSHDDLM-ALEGAYYNMVRAGDINMPDEVEKED-SIEDTKQKSLALFEKSFETS 674
            ..:|:|:::|.|||::|: .|:|.|.::||   :...|..|.:. |:|:.:..||:   |..:.|
plant   554 CVVHNGRIIETGSHEELLEKLDGQYTSLVR---LQQVDNKESDHISVEEGQASSLS---KDLKYS 612

  Fly   675 PLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISA 739
            |..|.....:::..:.|.:             :|.:..:...:|.|::.:.:.||.:.:.|.:.|
plant   613 PKEFIHSTSSNIVRDFPNL-------------SPKDGKSLVPSFKRLMSMNRPEWKHALYGCLGA 664

  Fly   740 VAVGFLYPAFAVIFGEFYAA--LAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGI 802
            ...|.:.|.::...|...:.  ||..|......|..||.:  :|||..|.|....|.|.|.|.|.
plant   665 ALFGAVQPIYSYSSGSMVSVYFLASHDQIKEKTRIYVLLF--VGLALFTFLSNISQHYGFAYMGE 727

  Fly   803 WLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSV 867
            :||.|:|......::..||.|||.:.||.||:.:||:.:|..::..:|..:|.::|.:|....:.
plant   728 YLTKRIRERMLGKILTFEVNWFDKDENSSGAICSRLAKDANMVRSLVGDRMSLLVQTISAVSITC 792

  Fly   868 SVAMYYNWKLALLCLANCPIIV-----GSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTV 927
            ::.:..:|:.:::.::..|:||     ..|:|:: |..||:..:    :|:.::|.|:::||||:
plant   793 AIGLVISWRFSIVMMSVQPVIVVCFYTQRVLLKS-MSRNAIKGQ----DESSKLAAEAVSNIRTI 852

  Fly   928 AGLRREADVIR--EYTEEIQRVEVLIRQKLRW-RGVLNSTMQASAFFAYAVALCYGGVLVSEGQL 989
            .....:..:|.  :..:|..|.: ..||.  | .|::..|.|:......|:...|||.|:::|::
plant   853 TAFSSQERIINLLKMVQEGPRKD-SARQS--WLAGIMLGTSQSLITCVSALNFWYGGKLIADGKM 914

  Fly   990 PFQDIIKVSETLLYGS--MMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI--QSPMGTIKNTLA 1050
            ..::.:::  .|::.|  .::|::...|........|...:|.:|||...|  ::|.|.:...:.
plant   915 MSKEFLEI--FLIFASTGRVIAEAGTMTKDLVKGSDAVASVFAVLDRNTTIEPENPDGYVPKKVK 977

  Fly  1051 KQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDE 1115
            .|::      :..:.|.||||||..|.....:::..|::.|:||.||.||||.:.|::|:|||.:
plant   978 GQIS------FSNVDFAYPTRPDVIIFQNFSIDIEDGKSTAIVGPSGSGKSTIISLIERFYDPLK 1036

  Fly  1116 GTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAH 1180
            |.:.||..||: ...|..:|..:.:||||||||..:|.|||.||.....:...|||.|||:||||
plant  1037 GIVKIDGRDIR-SCHLRSLRQHIALVSQEPTLFAGTIRENIMYGGASNKIDESEIIEAAKAANAH 1100

  Fly  1181 SFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDT 1245
            .||.||.|||||..|.||.|||||||||||||||:::||.:|||||||||||.|||.:||.||:.
plant  1101 DFITSLSNGYDTCCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSQSESVVQDALER 1165

  Fly  1246 ACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG--GIYAKLHKTQK 1300
            ...|||.:||||||||:|..|.|.|::||.|||.|||..|:::|  |.|..|...|:
plant  1166 LMVGRTSVVIAHRLSTIQKCDTIAVLENGAVVECGNHSSLLAKGPKGAYFSLVSLQR 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	208/530 (39%)
		MdlB	711..1299	CDD:440747	218/603 (36%)
ABCB18	NP_189480.1	MdlB	1..586	CDD:440747	212/554 (38%)
		MdlB	637..1221	CDD:440747	218/602 (36%)