Protein Alignment Mdr65 and ABCB17

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_189479.1
• Gene: ABCB17 / 822467
• AraportID: AT3G28380
• Length: 1240
• Species: Arabidopsis thaliana
• Alignment Length: 1286
• Identity: 453/1286 - (35%)
• Similarity: 707/1286 - (54%)
• Gaps: 114/1286 - (8%)

  Fly    43 GEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASRE 107
            |.||.:..|||        .|.||.|::...:.|       ||||
plant    38 GLIGAVGDGFI--------TPVVVFIFNTLLNNL-------GTSS-------------------- 67

  Fly   108 ENNEALYDDSISYGI--LLTIAS---VVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIG 167
             :|...:..:||..:  ||.:|.   |:.|:.|.    .:.....||..|||.|...:|:|||:|
plant    68 -SNNKTFMQTISKNVVALLYVACGSWVICFLEGY----CWTRTGERQAARMREKYLRAVLRQDVG 127

  Fly   168 WHDL--ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPL 230
            :.||  .|..:...|:..|...|:|.:|||:.:|:.....|:.:..:||...|:||:....:|.|
plant   128 YFDLHVTSTSDVITSISSDSLVIQDFLSEKLPNFLMNASAFVASYIVSFILMWRLTIVGFPFIIL 192

  Fly   231 VILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQ 295
            :::......:....::.:..|.|..||::||:.:||:|||.:||.|...:.::...|..:.|...
plant   193 LLVPGLMYGRALVSISRKIHEQYNEAGSIAEQAISSVRTVYAFGSENKMIGKFSTALRGSVKLGL 257

  Fly   296 WKGAFSGL---SDAVLKSMLYLSCAGAF--WYGVNLIIDDRNVENKEYTPAILM--IAFFGIIVG 353
            .:|...|:   |:.|..::      .||  |||..|::   |..:|..|..:::  |.:.|:.:|
plant   258 RQGLAKGITIGSNGVTHAI------WAFLTWYGSRLVM---NHGSKGGTVFVVISCITYGGVSLG 313

  Fly   354 ADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRP 418
             .:::....|.|:|....    .:.:||.....||....:|::|. .::|:|||..|.|.|.|||
plant   314 -QSLSNLKYFSEAFVAWE----RILEVIKRVPDIDSNKKEGQILE-RMKGEVEFNHVKFTYLSRP 372

  Fly   419 EVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNI 483
            |..:...|.::|.||:||||||.||.||||.:.||||||||:.|.:|:|.:.|.|..:.||||.:
plant   373 ETTIFDDLCLKIPAGKTVALVGGSGSGKSTVISLLQRFYDPIAGEILIDGVSIDKLQVNWLRSQM 437

  Fly   484 AVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQ 548
            .:|.||||||..:|.:||.:||..|:..|:..||..:.||.||:..|..|::.:||||.|:||||
plant   438 GLVSQEPVLFATSITENILFGKEDASLDEVVEAAKASNAHTFISQFPLGYKTQVGERGVQMSGGQ 502

  Fly   549 KQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVF 613
            |||||||||:|::||||||||||||||.:||:.||::||.||.||||||::||||.||.||.|..
plant   503 KQRIAIARAIIKSPKILLLDEATSALDSESERVVQESLDNASIGRTTIVIAHRLSTIRNADVICV 567

  Fly   614 IHDGKVLEEGSHDDLM-ALEGAYYNMVRAGDINMPDEVEKEDS-----IEDTKQKSLALFEKSFE 672
            ||:|:::|.|||::|: .::|.|.::|..      .::|.|:|     :..||.:.::|.:
plant   568 IHNGQIVETGSHEELLKRIDGQYTSLVSL------QQMENEESNVNINVSVTKDQVMSLSK---- 622

  Fly   673 TSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTI 737
                :|:..|.||:......|...:.|.      .|.:......:|:|::.:.:.||.:.:.|.:
plant   623 ----DFKYSQHNSIGSTSSSIVTNVSDL------IPNDNQPLVPSFTRLMVMNRPEWKHALYGCL 677

  Fly   738 SAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGI 802
            ||..||.|.|..|...|...:.......:....:|.:.....:|||..:.||...|.|.|.|.|.
plant   678 SAALVGVLQPVSAYSAGSVISVFFLTSHDQIKEKTRIYVLLFVGLAIFSFLVNISQHYGFAYMGE 742

  Fly   803 WLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSV 867
            :||.|:|....:.::..||.|||.::||.||:.:||:.:|..::..:|..:|.::|.:|..|.:.
plant   743 YLTKRIREQMLSKILTFEVNWFDIDDNSSGAICSRLAKDANVVRSMVGDRMSLLVQTISAVIIAC 807

  Fly   868 SVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRR 932
            .:.:...|:||::.::..|:||.....:..::.:...:..:..:|:.::|.|:::||||:.....
plant   808 IIGLVIAWRLAIVMISVQPLIVVCFYTQRVLLKSLSEKASKAQDESSKLAAEAVSNIRTITAFSS 872

  Fly   933 EADVIR--EYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDII 995
            :..:|:  :..:|..|.|.:.|..|  .|::..|.::......|:...|||.|:::|::..:...
plant   873 QERIIKLLKKVQEGPRRESVHRSWL--AGIVLGTSRSLITCTSALNFWYGGRLIADGKIVSKAFF 935

  Fly   996 KVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDR----KPKIQSPMGTIKNTLAKQLNLF 1056
            ::....:....::|.:...|...:..|.|...:|.:|||    :||  :|.|.:...:..|
plant   936 EIFLIFVTTGRVIADAGTMTTDLARGLDAVGSVFAVLDRCTTIEPK--NPDGYVAEKIKGQ---- 994

  Fly  1057 EGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHID 1121
              :.:..:.|.||||||..|.....:|:.:|::.|:||.||.||||.:.|::|:|||.:||:.||
plant   995 --ITFLNVDFAYPTRPDVVIFENFSIEIDEGKSTAIVGTSGSGKSTIIGLIERFYDPLKGTVKID 1057

  Fly  1122 HDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISL 1186
            ..||: ...|..:|..:.:|||||.||..:|.|||.||.....:...|||.|||:||||.||.||
plant  1058 GRDIR-SYHLRSLRKYISLVSQEPMLFAGTIRENIMYGGTSDKIDESEIIEAAKAANAHDFITSL 1121

  Fly  1187 PNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRT 1251
            .|||||..|.:|.|||||||||||||||:::||.:|||||||||||.:||::||.||:....|||
plant  1122 SNGYDTNCGDKGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSKSERVVQDALERVMVGRT 1186

  Fly  1252 CIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG--GIYAKLHKTQK 1300
            .|:|||||||:||.|:|.|:..|::||.|.|..|:.:|  |.|..|...|:
plant  1187 SIMIAHRLSTIQNCDMIVVLGKGKIVESGTHSSLLEKGPTGTYFSLAGIQR 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	212/537 (39%)
		MdlB	711..1299	CDD:440747	211/595 (35%)
ABCB17	NP_189479.1	MdlB	32..600	CDD:440747	228/622 (37%)
		MdlB	657..1236	CDD:440747	211/589 (36%)