DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and ABCB15

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_189475.1	Gene:	ABCB15 / 822463	AraportID:	AT3G28345	Length:	1240	Species:	Arabidopsis thaliana

Alignment Length:	1297	Identity:	455/1297 - (35%)
Similarity:	694/1297 - (53%)	Gaps:	132/1297 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IGWLF--FGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASRE 107
            :.||.  .|.|.......|.|.|::|.|                            |.:.|....
plant    30 VDWLLMGLGLIGAVGDGFTTPLVLLITS----------------------------KLMNNIGGS 66

  Fly   108 ENNEALYDDSISYG--ILLTIAS---VVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIG 167
            ..|...:..|||..  .||.:|.   ||.|:.|.    .:.....||..|||.|...:|:|||:|
plant    67 SFNTDTFMQSISKNSVALLYVACGSWVVCFLEGY----CWTRTGERQTARMREKYLRAVLRQDVG 127

  Fly   168 WHDL--ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPL 230
            :.||  .|..:...|:..|...|:|.:|||:.:|:.....|:.:..:.|...|:|.:....:|.|
plant   128 YFDLHVTSTSDVITSVSSDSFVIQDVLSEKLPNFLMSASTFVGSYIVGFILLWRLAIVGLPFIVL 192

  Fly   231 VILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQ 295
            :::......:....::.:.:|.|..||.:||:.:||:|||.:|.||:..:.::...|..:.|...
plant   193 LVIPGLMYGRALISISRKIREEYNEAGFVAEQAISSVRTVYAFSGERKTISKFSTALQGSVKLGI 257

  Fly   296 WKGAFSGL---SDAVLKSML-YLSCAGAFWYGVNLIIDDRNVENKEYTPA----ILMIAFFGIIV 352
            .:|...|:   |:.:..:|. ::|     |||..:::         |..|    :..:| ..|.:
plant   258 KQGLAKGITIGSNGITFAMWGFMS-----WYGSRMVM---------YHGAQGGTVFAVA-AAIAI 307

  Fly   353 GADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSR 417
            |..::......|:.|..|......:.:||:...|||..:.||..|. .:||:|||::|.|.||||
plant   308 GGVSLGGGLSNLKYFFEAASVGERIMEVINRVPKIDSDNPDGHKLE-KIRGEVEFKNVKFVYPSR 371

  Fly   418 PEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSN 482
            .|..:.....:|:.:|:||||||.||.||||.:.||||||||:.|.:|:|.:.|.|..::||||.
plant   372 LETSIFDDFCLRVPSGKTVALVGGSGSGKSTVISLLQRFYDPLAGEILIDGVSIDKLQVKWLRSQ 436

  Fly   483 IAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGG 547
            :.:|.|||.||..||.:||.:||..|:..::..||..:.||.||:.||..|.:.:||||.|:|||
plant   437 MGLVSQEPALFATTIKENILFGKEDASMDDVVEAAKASNAHNFISQLPNGYETQVGERGVQMSGG 501

  Fly   548 QKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIV 612
            ||||||||||:|::|.||||||||||||.:||:.||:||:.||.|||||:::||||.||.||.|.
plant   502 QKQRIAIARAIIKSPTILLLDEATSALDSESERVVQEALENASIGRTTILIAHRLSTIRNADVIS 566

  Fly   613 FIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPL 676
            .:.:|.::|.||||:||. ::|.|..:|..      .::||:|            ...|.:..|:
plant   567 VVKNGHIVETGSHDELMENIDGQYSTLVHL------QQIEKQD------------INVSVKIGPI 613

  Fly   677 NF-EKGQKNSVQFEEPIIKALIKDTNAQSAEAP-----------PEKPNFFRTFSRILQLAKQEW 729
            :. .|..:||.:     :..|.:.::|.|...|           |:.|    :|.|:|.:...||
plant   614 SDPSKDIRNSSR-----VSTLSRSSSANSVTGPSTIKNLSEDNKPQLP----SFKRLLAMNLPEW 669

  Fly   730 CYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQT 794
            ...:.|.|||...|.:.||:|...|...:.......::...:|.:.:.:.:|||.|:.|:...|.
plant   670 KQALYGCISATLFGAIQPAYAYSLGSMVSVYFLTSHDEIKEKTRIYALSFVGLAVLSFLINISQH 734

  Fly   795 YLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQA 859
            |.|.|.|.:||.|:|....:.::..||||||.:.||.||:.:||:.:|..::..:|..::.::|.
plant   735 YNFAYMGEYLTKRIRERMLSKVLTFEVGWFDRDENSSGAICSRLAKDANVVRSLVGDRMALVVQT 799

  Fly   860 LSNFISSVSVAMYYNWKLALLCLANCPIIV-----GSVILEAKMMSNAVVREKQVIEEACRIATE 919
            :|....:.::.:...|:|||:.:|..|:|:     ..|:|  |.||...::.:   :|:.::|.|
plant   800 VSAVTIAFTMGLVIAWRLALVMIAVQPVIIVCFYTRRVLL--KSMSKKAIKAQ---DESSKLAAE 859

  Fly   920 SITNIRTVAGLRREADVIR--EYTEEIQRVEVLIRQKLRWRGVLNSTM-QASAFFAYAVALCYGG 981
            :::|:||:.....:..:::  |..:|..|.| .|||.  |.......| |:.....:|:...|||
plant   860 AVSNVRTITAFSSQERIMKMLEKAQESPRRE-SIRQS--WFAGFGLAMSQSLTSCTWALDFWYGG 921

  Fly   982 VLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI--QSPMGT 1044
            .|:.:|.:..:.:.:....|:....::|.:.:.|...:....|...:|.:|||...|  :.|.|.
plant   922 RLIQDGYITAKALFETFMILVSTGRVIADAGSMTTDLAKGSDAVGSVFAVLDRYTSIDPEDPDGY 986

  Fly  1045 IKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQR 1109
            ....:..|      |.:..:.|.||||||..|.....:::.:|::.|:||.||.||||.:.|::|
plant   987 ETERITGQ------VEFLDVDFSYPTRPDVIIFKNFSIKIEEGKSTAIVGPSGSGKSTIIGLIER 1045

  Fly  1110 YYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAA 1174
            :|||.:|.:.||..||: ...|..:|..:.:||||||||..:|.|||.||.....:...|||.||
plant  1046 FYDPLKGIVKIDGRDIR-SYHLRSLRRHIALVSQEPTLFAGTIRENIIYGGVSDKIDEAEIIEAA 1109

  Fly  1175 KSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLV 1239
            |:||||.||.||..||||..|.||.|||||||||||||||:::||.:|||||||||||.|||::|
plant  1110 KAANAHDFITSLTEGYDTYCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSQSERVV 1174

  Fly  1240 QQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG--GIYAKLHKTQ 1299
            |.||:....|||.:||||||||:||.|.|.|:..|::||:|.|..|:|:|  |||..|...|
plant  1175 QDALERVMVGRTSVVIAHRLSTIQNCDAIAVLDKGKLVERGTHSSLLSKGPTGIYFSLVSLQ 1236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	446/1249 (36%)
		ABC_membrane	108..354	CDD:279056	67/260 (26%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	128/237 (54%)
		ABC_membrane	736..1006	CDD:279056	74/277 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	129/241 (54%)
ABCB15	NP_189475.1	PTZ00265	34..1235	CDD:240339	452/1290 (35%)
		ABC_membrane	39..299	CDD:279056	73/305 (24%)
		ABC_MTABC3_MDL1_MDL2	359..597	CDD:213216	128/243 (53%)
		ABC_membrane	676..935	CDD:279056	73/266 (27%)
		ABC_MTABC3_MDL1_MDL2	995..1236	CDD:213216	129/241 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	90	1.000	Domainoid score	I2655
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790