DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and abcb5

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_001922717.3	Gene:	abcb5 / 798527	ZFINID:	ZDB-GENE-030131-6414	Length:	1338	Species:	Danio rerio

Alignment Length:	1331	Identity:	529/1331 - (39%)
Similarity:	791/1331 - (59%)	Gaps:	67/1331 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            ::.|...|.|:.|.::.....:..||.:.:.|.:|||::|..|:..:..|.:......:.||.:.
Zfish    38 DKPEEPPSDSKHKGKKGKNSKDNKEPMKSVGFFQLFRYATCPEVFLMLIGLLCAAAHGVALPLMC 102

  Fly    67 IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGI--------- 122
            :::.:.|    |..:|.|.:.|   |..|.|..|........|.......|...||
Zfish   103 VVFGQMT----DSFVQSGQTYN---LTGFNGNFTSNFTFTLNNTSTCLAGSPEIGIEPKMTKQAY 160

  Fly   123 -LLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVE 186
             .:.|...|: :.|.|.|.:|.:.|.:|..|:|.|.|.:::.|.:.|.|..........:.||:.
Zfish   161 FFIGIGGAVL-VLGTFQVMLFLLTAAKQTKRIRQKYFHAILHQQMSWFDTHPIGELNIRLTDDIN 224

  Fly   187 KIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQE 251
            .|.||:.:|:..||.....||..:.|.|.:||||||.:.:..||:.......:|....||::|..
Zfish   225 TINDGLGDKIAVFVQFFCSFISGLVIGFVFGWKLTLVILAVSPLLAGSAAVWSKILASLTSKELT 289

  Fly   252 SYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSC 316
            :||.||.:|||||.:|||||:|.|:|..|::||..||.|:.....|...:.:|..:.:.:::.:.
Zfish   290 AYAKAGAVAEEILVAIRTVVAFNGQKKAVEKYEKNLVEAKDFGVKKAISTNVSMGLTQFIVFATY 354

  Fly   317 AGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVI 381
            |.|||||..|.:|    |.:.||...::..||.:::|..::.:.||.||:.|.|||.|..::|.|
Zfish   355 ALAFWYGTKLSVD----EPENYTIGRVLTVFFSVMIGTFSLGQGAPNLEAIAKARGAAYEVYKTI 415

  Fly   382 DLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGK 446
            |:...||..|.:|...: .:|||:||:::.|.||||.:|.:.:|:::::..|:|:||||:|||||
Zfish   416 DMPRPIDSSSKEGHKPD-RVRGDIEFKNINFNYPSRKDVTILQGMSLKVPHGKTIALVGASGCGK 479

  Fly   447 STCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQK 511
            ||.:|||||||||..|.|.||..|||..|::|||.|:.:|.||||||..|||:||.||:..||..
Zfish   480 STTIQLLQRFYDPDSGEVTLDGHDIRSLNVRWLRENMGIVSQEPVLFGTTIAENIRYGREDATDA 544

  Fly   512 EIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDY 576
            :||.|..:|.|::||:.||:...:|:||||:||||||||||||||||::|||||||||||||||.
Zfish   545 DIEQAIKEANAYDFISKLPDKLNTMVGERGAQLSGGQKQRIAIARALVKNPKILLLDEATSALDT 609

  Fly   577 QSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV-- 639
            |||..||.|||.|..||||||::||||.||.||.|....:|:|:|:|||.:|||.:|.||::|
Zfish   610 QSESIVQAALDKARAGRTTIVIAHRLSTIRSADIIAGFSEGRVVEQGSHRELMAKKGVYYSLVTQ 674

  Fly   640 -----RAGDINMPDEVEKEDSIEDTKQKS---------------LALFEKSFETSPLNFEKGQKN 684
                 :..:::..::..::||.|:|.:.|               ...|.||.:.|.......:|:
Zfish   675 QTSGRQNEELDANEDDTQDDSEEETGEDSSDPEILEGGVEMKLERGSFRKSLKRSSKRRSSRKKS 739

  Fly   685 SVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAF 749
                     |...||..|:..|. ||.|     |::||.|.|.:|.||::||.:::..|.:||..
Zfish   740 ---------KKSRKDKKAKKEEI-PEMP-----FTKILALNKPDWPYLVVGTFASLVGGAVYPCV 789

  Fly   750 AVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFN 814
            |::|.:.....||.|||...::|.:.|...|.:..:..|..|.|.::|..:|..||.|:|:..|.
Zfish   790 AILFAKIIGVFAEPDPEVKRQKTMMFSLLYLLIGVVAFLTYFFQGFMFGKSGELLTMRLRSQAFK 854

  Fly   815 AMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLAL 879
            |:|.||:|||||.||:||.|:.:|:.:|..::||.|..|......:...:.:|.||..:.|:|.|
Zfish   855 AIVRQEIGWFDDNNNAVGILTTKLATDASLVKGAAGSRLGLATNTICALLIAVIVAFVFCWQLTL 919

  Fly   880 LCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEI 944
            |.||..|.:.|:..::.:..:....:::..:|.:.:|:||::.|.:||..|.||.....::.:.:
Zfish   920 LILACVPFLTGANFIQLRATAGHTSKDQSALEMSGKISTETVENFKTVVALTREDVFFHKFIDSL 984

  Fly   945 QRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLA 1009
            .........|....|:..:..||..:...|....:|..|::.....::::..|...:::.:|.:.
Zfish   985 STPYKASLCKAPIYGITFALAQAIPYLVNAAIFRFGAWLIAHCYTEYENVFLVFSVIVFAAMNIG 1049

  Fly  1010 QSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPD 1073
            ||.:|.|.|:.|..|..|:.|:|::||:|.     |.:...::.:.|.| :.::.:||.|||||:
Zfish  1050 QSSSFAPDFAKAKAAAGRIIQLLEKKPEID-----IYDESGERPSTFSGNIDFKDVQFSYPTRPN 1109

  Fly  1074 AKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKL 1138
            .|:|.||::.|.:|||:||||.|||||||.:|||:|:|||..|.:.:|..| ...:.|..:||::
Zfish  1110 VKVLQGLNVSVRQGQTLALVGSSGCGKSTTIQLLERFYDPAGGQVLVDGRD-SKSVNLAWLRTQM 1173

  Fly  1139 GIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSG 1203
            |:|||||.||:.:|:|||.||||.|:|:..||..|||.||.|:||::||:.|:||:|.:||||||
Zfish  1174 GLVSQEPILFDCTISENIQYGDNSRTVTQEEIEEAAKKANIHNFILTLPDKYNTRVGDKGTQLSG 1238

  Fly  1204 GQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVI 1268
            ||||||||||||||.||:|||||||||||.:||::||.|||.|..|||||||||||:|:||||:|
Zfish  1239 GQKQRIAIARALVRKPKLLLLDEATSALDTESEKIVQAALDEARLGRTCIVIAHRLTTIQNADII 1303

  Fly  1269 CVIQNGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            .|:|||:|||||.|.||:::...|..|...|
Zfish  1304 VVVQNGKVVEQGTHAQLMAKQEAYFALVNAQ 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	509/1242 (41%)
		ABC_membrane	108..354	CDD:279056	81/255 (32%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	141/243 (58%)
		ABC_membrane	736..1006	CDD:279056	73/269 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	145/239 (61%)
abcb5	XP_001922717.3	PTZ00265	48..1328	CDD:240339	523/1313 (40%)
		ABC_membrane	88..389	CDD:279056	93/312 (30%)
		ABC_MTABC3_MDL1_MDL2	438..675	CDD:213216	141/236 (60%)
		ABC_membrane	776..1046	CDD:279056	73/269 (27%)
		ABC_MTABC3_MDL1_MDL2	1095..1334	CDD:213216	145/239 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7260
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.730