DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr65 and Abcb5

DIOPT Version :9

Sequence 1:	NP_476831.1	Gene:	Mdr65 / 38726	FlyBaseID:	FBgn0004513	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_084237.1	Gene:	Abcb5 / 77706	MGIID:	1924956	Length:	1255	Species:	Mus musculus

Alignment Length:	1303	Identity:	520/1303 - (39%)
Similarity:	755/1303 - (57%)	Gaps:	79/1303 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEF 72
            |:...|..||:.|.. |.:...||   ::|||:...:|..:..|.:...|...|:|.:.::..|.
Mouse    13 TNQRYGPLQEQVPKV-GNQAVGPI---EIFRFADNLDIVLMTLGILASMINGATVPLMSLVLGEI 73

  Fly    73 TSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREEN----NEALYDDSISYGILLTI------A 127
            :..|::                  |....||.::.:|    .|.|.:|.    |:||:      |
Mouse    74 SDHLIN------------------GCLVQTNRTKYQNCSQTQEKLNEDI----IVLTLYYIGIGA 116

  Fly   128 SVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGI 192
            :.::|  |...:..:.:.|.||.||:|.:.|.|::.|||.|.|.:........|..|:.|:.|||
Mouse   117 AALIF--GYVQISFWVITAARQTTRIRKQFFHSILAQDISWFDGSDICELNTRMTGDINKLCDGI 179

  Fly   193 SEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAG 257
            .:|:......:.||.|.:.||....|||:|.|.|..||::..:...::....||::|.::|:.||
Mouse   180 GDKIPLMFQNISGFSIGLVISLIKSWKLSLVVLSTSPLIMASSALCSRMIISLTSKELDAYSKAG 244

  Fly   258 NLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWY 322
            .:|||.||||:||.:||.::.|:|||...|..|:.|...:...|.||...:...:..:...||||
Mouse   245 AVAEEALSSIQTVTAFGAQEKEIQRYTQHLKDAKDAGIKRATASKLSLGAVYFFMNGAYGLAFWY 309

  Fly   323 GVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKI 387
            |.:||...    ...||...::..||.:|..:..|...||.||:|..|||.|.|:|:|||....|
Mouse   310 GTSLIFGG----EPGYTIGTILAVFFSVIHSSYCIGSVAPHLETFTVARGAAFNIFQVIDKKPNI 370

  Fly   388 DPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQL 452
            |..||.| .:...:.|::||::|.|.|||||...|.:|||::|:||:||||||.||.||||.|||
Mouse   371 DNFSTAG-FVPECIEGNIEFKNVSFSYPSRPSAKVLKGLNLKIKAGETVALVGPSGSGKSTTVQL 434

  Fly   453 LQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAA 517
            |||.|||..|.:.:|:.|||..|::..|..|.||.||||||..||..||.:|:.|..:||:|.||
Mouse   435 LQRLYDPEDGCITVDENDIRAQNVRHYREQIGVVRQEPVLFGTTIGNNIKFGREGVGEKEMEQAA 499

  Fly   518 TQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQV 582
            .:|.|::||...|:.:.:::||:|:|:||||||||||||||::|||||:|||||||||.:||..|
Mouse   500 REANAYDFIMAFPKKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLV 564

  Fly   583 QQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMP 647
            |.||:.||||||||||:||||.|||||.||.:.||.|:|:|:|.:|||.:|.||::..|.||...
Mouse   565 QTALEKASKGRTTIVVAHRLSTIRGADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQDIKKV 629

  Fly   648 DEVEKEDSIEDTKQKSL-ALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEK 711
            ||..:..:.......|. :|.:.:...:|.        :.|.||.:        :.|....|..
Mouse   630 DEQMESRTCSTAGNASYGSLCDVNSAKAPC--------TDQLEEAV--------HHQKTSLPEV- 677

  Fly   712 PNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLS 776
                 :..:|.:|:|.||.:::|||:::...|.::|.|::|||:......:|: :..|::.|.|.
Mouse   678 -----SLLKIFKLSKSEWPFVVLGTLASALNGSVHPVFSIIFGKLVTMFEDKN-KATLKQDAELY 736

  Fly   777 WACLGLAFLTGLVCFLQTYLF-NYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSG 840
            ...|.:..:..||.:|...|| ..|...|..|:|...|.||:.|::.|:||:.|:.|||:..|:.
Mouse   737 SMMLVVLGIVALVTYLMQGLFYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAV 801

  Fly   841 EAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVR 905
            :...||||....|..:.|.:||...|:.::..|.|::.||.|:..|::..:.:::...|:....|
Mouse   802 DVAQIQGAATSRLGIVTQDVSNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANR 866

  Fly   906 EKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAF 970
            :||.::.|.:||||::.|||||..|.||....:.|.|.:|.......::....|...:...|...
Mouse   867 DKQALKRAGKIATEAVENIRTVVSLTRERAFEQMYEETLQTQHRNALKRAHITGCCYAVSHAFVH 931

  Fly   971 FAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRK 1035
            ||:|....:|..|:..|::..:.:..|...:.||:|.:.::|.:.|.:|.|......||.:|..|
Mouse   932 FAHAAGFRFGAYLIQAGRMMPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGASHLFALLKNK 996

  Fly  1036 PKIQ--SPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSG 1097
            |.|.  |..|...:|.       || :.:|.:.|.||.||:..:|..:.|.:.||:|||.||.||
Mouse   997 PTINSCSQSGEKPDTC-------EGNLEFREVSFVYPCRPEVPVLQNMSLSIEKGKTVAFVGSSG 1054

  Fly  1098 CGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNR 1162
            ||||||||||||:|||.:|.:.:|..|:: :|.:..:|::..||||||.||..|||||||||||.
Mouse  1055 CGKSTCVQLLQRFYDPMKGQVLLDGVDVK-ELNVQWLRSQTAIVSQEPVLFNCSIAENIAYGDNS 1118

  Fly  1163 RSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEA 1227
            |.|.:.||...|.:||.||||..||..|:|.:|.||.|||||||||:||||||:|.|||||||||
Mouse  1119 RMVPLEEIKEVADAANIHSFIEGLPRKYNTLVGLRGVQLSGGQKQRLAIARALLRKPKILLLDEA 1183

  Fly  1228 TSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIY 1292
            |||||.:||::||||||.|..|:||:|:||||||:||||:|.|:|||.:.|||.|.:|:..|..|
Mouse  1184 TSALDNESEKVVQQALDKARRGKTCLVVAHRLSTIQNADMIVVLQNGSIKEQGTHQELLRNGDTY 1248

  Fly  1293 AKL 1295
            .||
Mouse  1249 FKL 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	502/1220 (41%)
		ABC_membrane	108..354	CDD:279056	82/255 (32%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	140/236 (59%)
		ABC_membrane	736..1006	CDD:279056	79/270 (29%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	141/237 (59%)
Abcb5	NP_084237.1	PTZ00265	48..1250	CDD:240339	506/1261 (40%)
		ABC_membrane	53..334	CDD:279056	89/308 (29%)
		ABC_MTABC3_MDL1_MDL2	387..624	CDD:213216	140/236 (59%)
		ABC_membrane	697..963	CDD:279056	77/266 (29%)
		ABC_MTABC3_MDL1_MDL2	1017..1252	CDD:213216	141/236 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I3072
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.730