Protein Alignment Mdr65 and Abcb8

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_083296.2
• Gene: Abcb8 / 74610
• MGIID: 1351667
• Length: 717
• Species: Mus musculus
• Alignment Length: 555
• Identity: 198/555 - (35%)
• Similarity: 302/555 - (54%)
• Gaps: 49/555 - (8%)

  Fly   120 YGI--LLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMV 182
            ||:  |||...:|:          .:.:..|....||..||||::||||.:.|..........:.
Mouse   184 YGVQGLLTFGYLVL----------LSHIGERMAMDMRKALFSSLLRQDIAFFDAKKTGQLVSRLT 238

  Fly   183 DDVEKIRDG----ISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQG 243
            .||::.:..    ||:.:..... |:|.::::::   ...:|||.::...|.::.:...:.....
Mouse   239 TDVQEFKSSFKLVISQGLRSCTQ-VIGSLVSLSM---LSPRLTLMLAVVTPALMGVGTLMGSGLR 299

  Fly   244 KLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRY----ENFLVPARKASQWKGAFSGLS 304
            ||:.:.||..|.|..:|:|.|.::|||.:|..||.|.:||    |:....|.:..:....|.|||
Mouse   300 KLSRQCQEQIARATGVADEALGNVRTVRAFAMEKREEERYQAELESCCCKAEELGRGIALFQGLS 364

  Fly   305 DAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESF-- 367
            :.....|:    .|..:.|.:|      |..::.....||    ..:|.:..:.|:...|...
Mouse   365 NIAFNCMV----LGTLFIGGSL------VAGQQLKGGDLM----SFLVASQTVQRSMASLSVLFG 415

  Fly   368 ATARG--CATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRI 430
            ...||  ....:|:.:.| |.:.||:....:.|..:||.:.||:|.|.||.||...|.:...:::
Mouse   416 QVVRGLSAGARVFEYMAL-SPVIPLTGGYCIPNKDIRGSITFQNVTFSYPCRPGFNVLKDFTLKL 479

  Fly   431 RAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSN-IAVVGQEPVLFL 494
            .:|:.|||||.||.||:|...||:|||||..|||.||..|:|..|..|||.. |..:.||||||.
Mouse   480 PSGKIVALVGQSGGGKTTVASLLERFYDPEAGSVTLDGHDLRTLNPSWLRGQVIGFISQEPVLFA 544

  Fly   495 GTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALI 559
            .||.:||.:||..|:.:|:..||.:|.|||||::.|:.|.:::||||:.||||||||:|||||||
Mouse   545 TTIMENIRFGKLDASDEEVYTAAREANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALI 609

  Fly   560 QNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGS 624
            :.|.:|:|||||||||.:||:.||:|||.||.|||.:|::||||.:|.|..|:.:.:|:|.|.|:
Mouse   610 KQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGT 674

  Fly   625 HDDLMALEGAYYNMVR-----AGDINMPDEVEKED 654
            |::|:...|.|..::|     |...:.|...:.||
Mouse   675 HEELLKKGGLYSELIRRQTLDASLTSTPPAEKPED 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	198/555 (36%)
		ABC_membrane	108..354	CDD:279056	60/243 (25%)
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216	122/242 (50%)
		ABC_membrane	736..1006	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216
Abcb8	NP_083296.2	MdlB	116..695	CDD:224055	194/539 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	695..717		4/15 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810