Protein Alignment Mdr65 and Abcb9

DIOPT Version :9

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_071574.1
• Gene: Abcb9 / 63886
• RGDID: 620254
• Length: 762
• Species: Rattus norvegicus
• Alignment Length: 632
• Identity: 203/632 - (32%)
• Similarity: 319/632 - (50%)
• Gaps: 93/632 - (14%)

  Fly   707 APPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALA------EKDP 765
            ||.|:.: ..|..::|...|.:..:|:     |.:...:..|....|..:|...|      :|..
  Rat   160 APAEQAS-GATLQKLLSYTKPDVAFLV-----AASFFLIVAALGETFLPYYTGRAIDSIVIQKSM 218

  Fly   766 EDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNS 830
            :.......|:   || ||..:.|...::..:|......|..|:|...|.::|:||..:||:  |.
  Rat   219 DQFTTAVVVV---CL-LAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDE--NR 277

  Fly   831 VGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMY-YNWKLALLCLANCPIIVGSVIL 894
            .|.|.:||:.:...:...:...::..::.... ::.|.|.|: .:|:|:|:.....|||:
  Rat   278 TGDLISRLTSDTTMVSDLVSQNINIFLRNTVK-VTGVVVFMFSLSWQLSLVTFMGFPIIM----- 336

  Fly   895 EAKMMSN-------AVVREKQ-VIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLI 951
               |:||       .:.:|.| .:..|...|.|:|:.::||          |.:..|.:..||.:
  Rat   337 ---MVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTV----------RSFANEEEEAEVFL 388

  Fly   952 RQKLRWRGVLNSTMQASAFFAY------------AVALCYGGVLVSEGQLPFQDIIKVSETLLYG 1004
            | ||:....|| ..:|:|:.:|            ...|.|||.||..||:...::|..   ::|
  Rat   389 R-KLQQVYKLN-RKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAF---IIY- 447

  Fly  1005 SMMLAQSLAFTPAFSAALIAG----HRLFQILDRKPKIQSPMGTIKNTLAKQLNL----FEG-VR 1060
            ..:|...:....:..:.|:.|    .::|:.:||:|           |:.....|    .|| |.
  Rat   448 EFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP-----------TMVHDGRLAPDHLEGRVD 501

  Fly  1061 YRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDI 1125
            :..:.|.|.|||..::|..:...:..|:..||||.||.|||:||.:|:.:|....|.:.:|.:.|
  Rat   502 FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGEPI 566

  Fly  1126 ---QHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLP 1187
               .|..    :...:.:|||||.||.|||.:||:||  ..:|....::.||:.||||.||:.|.
  Rat   567 GAYDHKY----LHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQ 625

  Fly  1188 NGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTC 1252
            :||.|..|.:|.|||||||||:|:||||||||.:|:|||||||||.:||.|:|||:.......|.
  Rat   626 DGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTV 690

  Fly  1253 IVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            ::||||||||:.|.:|.|:..|:||:||.|.||::|||:||||.:.|
  Rat   691 LIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	PTZ00265	91..1300	CDD:240339	203/632 (32%)
		ABC_membrane	108..354	CDD:279056
		ABC_MTABC3_MDL1_MDL2	405..642	CDD:213216
		ABC_membrane	736..1006	CDD:279056	69/296 (23%)
		ABC_MTABC3_MDL1_MDL2	1059..1299	CDD:213216	115/242 (48%)
Abcb9	NP_071574.1	3a01208	44..734	CDD:273363	201/627 (32%)
		ABC_membrane	189..451	CDD:279056	68/292 (23%)
		ABCC_TAP	489..714	CDD:213215	104/230 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810